anti-Programmed Cell Death 10 (PDCD10) Anticorps

PDCD10 encodes an evolutionarily conserved protein associated with cell apoptosis. De plus, nous expédions PDCD10 Protéines (10) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PDCD10 11235 Q9BUL8
PDCD10 56426 Q8VE70
PDCD10 494345 Q6NX65
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Showing 10 out of 69 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB PDCD10 Antibody (Center)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PDCD10 antibody detected the PDCD10 protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
Humain Lapin Inconjugué WB Western blot analysis in CEM cell line lysates (35ug/lane). 400 μL Connectez-vous pour afficher 2 to 3 Days
Humain Lapin Inconjugué IHC, WB 100 μL Connectez-vous pour afficher 16 Days
Humain Lapin Inconjugué IF, WB Immunofluorescence staining (green) of Human foreskin (cryo-section of unfixed tissue) with anti-Human CCM3 antibody Cat.-No. AP26023PU (K5548, dilution1/50). A) Note specific staining in the epidermis and in the wall of microvessels. B) Negative control of a consecutive section. Nuclei counter-stained with Dapi (blue). <em>Specimen provided by Prof. Dr. J. Wilting, Goettingen.The experiment was performed by the research group of Prof. Dr. J. Wilting, University Göttingen, Germany.</em> Western Blot using Anti Human CCCM3 antibody Cat.-No. AP26023PU. The experiment was performed by Elisabetta  Dejana's group. IF OM.IEO-Campus, Milan Italy. 0.1 mg Connectez-vous pour afficher 6 to 8 Days
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti PDCD10 Polyclonal Antibody (ABIN872581), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Connectez-vous pour afficher 3 to 7 Days
Humain Lapin Inconjugué IHC Immunohistochemistry of paraffin-embedded rat spleen using PDCD10 antibody (ABIN5971472) at dilution of 1/200 (40x lens). 100 μL Connectez-vous pour afficher 11 to 16 Days
Humain Lapin Inconjugué ELISA, IHC, WB   100 μL Connectez-vous pour afficher 11 to 12 Days
Humain Souris Inconjugué ELISA, WB Western Blot detection against Immunogen (37.84 KDa) . 100 μg Connectez-vous pour afficher 11 to 12 Days
Humain Lapin Alexa Fluor 647 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
Humain Lapin Alexa Fluor 488 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days

Plus d’anticorps contre PDCD10 partenaires d’interaction

Human Programmed Cell Death 10 (PDCD10) interaction partners

  1. Over-expression of PDCD10 in HeLa cells increased the resistance to doxorubicin.

  2. The identified endothelial signalling pathway of CCM3-DLL4 (Montrer DLL4 Anticorps)/Notch (Montrer NOTCH1 Anticorps)-EphB4 (Montrer EPHB4 Anticorps)-Erk1/2 may provide an insight into mechanism of CCM3-ablation-mediated angiogenesis.

  3. Case-control study to investigate the possible association of others polymorphisms (c.485+65 C/G, c.989+63 C/G, c.1980 A/G in CCM1 (Montrer KRIT1 Anticorps) gene, c.472+127 C/T in CCM2 (Montrer CCM2 Anticorps) and c.150 G/A in CCM3) with cerebral cavernous malformations. The five polymorphisms were characterized in 64 sporadic patients and in 90 healthy controls by ASO-PCR. Results suggest that some polymorphisms in CCM genes could play an important role in the disease.

  4. CCM3 restrains ANGPT2 (Montrer UNC13B Anticorps)release from endothelial cells and maintains endot (Montrer VAMP3 Anticorps)helial junctions. CCM3 depletion leads to increa (Montrer ANGPT2 Anticorps)sed ANGPT2 release.

  5. Data indicated that rs9853967 and rs11714980 polymorphisms in CCM3 and SERPINI1respectively could be associated with a protective role in cerebral cavernous malformations disease.

  6. Inhibition of Notch (Montrer NOTCH1 Anticorps) and activation of VEGF (Montrer VEGFA Anticorps)/p38 (Montrer CRK Anticorps) signaling were involved in miR (Montrer MLXIP Anticorps)-425-5p/CCM3 mediated inhibition of angiogenesis by sodium arsenite.

  7. Loss of endothelial programmed cell death 10 activates glioblastoma cells and promotes tumor growth.

  8. Studies suggest that the 3 proteins of the Cerebral Cavernous Malformations (CCM) complex KRIT1/CCM1 (Montrer KRIT1 Anticorps), CCM2/malcavernin (Montrer CCM2 Anticorps) and CCM3/PDCD10 not only require one another for reciprocal stabilization, but also act as a platform for signal transduction.

  9. Study highlights the potential role of CCM3 in regulating tight junction complex organization and brain endothelial barrier permeability through CCM3-ERK1/2-cortactin (Montrer CTTN Anticorps) cross-talk

  10. A novel CCM3 missense mutation (c.422T>G) detected in 2 Greek brothers with cerebral cavernous malformations causes a loss of function in Pdcd10 protein due to its localization in the 8th helix. It affects Leu141. It may play a role in angiogenesis.

Mouse (Murine) Programmed Cell Death 10 (PDCD10) interaction partners

  1. CCM3 suppresses UNC13B (Montrer UNC13B Anticorps)- and vesicle-associated membrane protein 3 (VAMP3 (Montrer VAMP3 Anticorps))-dependent exocytosis of angiopoietin 2 (ANGPT2 (Montrer ANGPT2 Anticorps)) in brain endothelial cells. CCM3 deficiency in endothelial cells augments the exocytosis and secretion of ANGPT2 (Montrer ANGPT2 Anticorps), which is associated with destabilized endothelial cell junctions, enlarged lumen formation and endothelial cell-pericyte dissociation.

  2. CCM3 expression and it's role during ovary and testis development

  3. Study shows that PDCD10 mutations result in vascular permeability mediated by ROCK activity and a particularly severe clinical phenotype of patients and mouse model for cerebral cavernous malformation disease.

  4. Data show that sulindac sulfide (Montrer SQRDL Anticorps) and sulindac sulfone, which attenuate beta-catenin (Montrer CTNNB1 Anticorps) transcription activity, reduce vascular malformations in endothelial programmed cell death 10 protein CCM3-deficient mice.

  5. CCM3 has both cell autonomous and cell non-autonomous functions in neural progenitors and is specifically required in radial glia and newly born pyramidal neurons migrating through the subventricular zone

  6. Although CCM3 stabilizes STK24, it counteracts STK24-mediated inhibition of exocytosis by recruiting STK24 away from the C2B domain through its Ca(2+)-sensitive interaction with UNC13D C2A domain.

  7. Pdcd10 has a different role in cerebral cavernous malformation than Ccm2 (Montrer CCM2 Anticorps) and Krit1 (Montrer KRIT1 Anticorps)

  8. Ccm3 has both neural cell autonomous and nonautonomous functions.

  9. Stabilization of VEGFR2 (Montrer KDR Anticorps) signaling by cerebral cavernous malformation 3 (also known as PDCD10) is critical for vascular development.

Zebrafish Programmed Cell Death 10 (PDCD10) interaction partners

  1. CCM3 plays a role distinct from CCM1 (Montrer KRIT1 Anticorps)/2 in Cerebral cavernous malformations pathogenesis, and acts via GCKIII activity to regulate cranial vasculature integrity and development.

  2. Sequence conservation and binding studies suggest that CCM3 may preferentially heterodimerize with GCKIII proteins through a manner structurally analogous to that employed for CCM3 homodimerization.

  3. The newly mapped STK25 (Montrer STK25 Anticorps) and MST4 (Montrer MST4 Anticorps) interaction domain within the CCM3 protein plays a crucial role for vascular development in zebrafish.

PDCD10 profil antigène

Profil protéine

This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with PDCD10

  • programmed cell death 10 (PDCD10) anticorps
  • programmed cell death 10 (Pdcd10) anticorps
  • programmed cell death 10 S homeolog (pdcd10.S) anticorps
  • programmed cell death 10a (pdcd10a) anticorps
  • 2410003B13Rik anticorps
  • Ccm3 anticorps
  • ccm3a anticorps
  • pdcd10 anticorps
  • Tfa15 anticorps
  • Tfar15 anticorps
  • zgc:65826 anticorps

Protein level used designations for PDCD10

TF-1 cell apoptosis-related protein 15 , apoptosis-related protein 15 , cerebral cavernous malformations 3 protein , programmed cell death protein 10 , programmed cell death 10 , programmed cell death protein 10-A

11235 Homo sapiens
100232628 Taeniopygia guttata
56426 Mus musculus
494345 Rattus norvegicus
425003 Gallus gallus
100157978 Sus scrofa
379916 Xenopus laevis
506411 Bos taurus
393527 Danio rerio
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