Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) Protéines (PDCD4)

PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding.

afficher tous les protéines Gène GeneID UniProt
Humain PDCD4 PDCD4 27250 Q53EL6
Souris PDCD4 PDCD4 18569 Q61823
Rat PDCD4 PDCD4 64031 Q9JID1
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Top PDCD4 Protéines sur anticorps-enligne.fr

Showing 10 out of 11 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$8,498.50
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$8,498.50
Détails
Escherichia coli (E. coli) Humain Inconjugué Figure annotation denotes ug of protein loaded and % gel used. 100 μg Connectez-vous pour afficher 6 to 8 Days
$364.64
Détails
Escherichia coli (E. coli) Humain His tag   50 μg Connectez-vous pour afficher 4 Days
$385.00
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Levure Poulet His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,314.67
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,322.00
Détails
Levure Orang-Utan His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,322.00
Détails
Escherichia coli (E. coli) Humain His tag   10 μg Connectez-vous pour afficher 15 to 16 Days
$225.00
Détails
Escherichia coli (E. coli) Humain Inconjugué   1 mg Connectez-vous pour afficher 2 to 3 Days
$5,723.08
Détails

Plus protéines pour Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) partenaires d'interaction

Human Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. miR206 promoted the onset of SANFH by inducing apoptosis and suppressed the proliferation of osteoblasts, which was dependent on the inhibition of PDCD4.

  2. Results found PDCD4 as a target gene of miR (Montrer MLXIP Protéines)-93 and miR (Montrer MLXIP Protéines)-93 could down-regulate the expression of PDCD4 by directly targeting its 3'-UTR. The re-expression of PDCD4 could attenuate the hepatocellular carcinoma (HCC (Montrer FAM126A Protéines)) cell invasion and migration induced by miR (Montrer MLXIP Protéines)-93, while the knockdown of PDCD4 would promote HCC (Montrer FAM126A Protéines) cell migration and invasion via the EMT (Montrer ITK Protéines) pathway.

  3. Reduced expression of PDCD4 was found in decidual and chorionic tissues, and peripheral blood mononuclear cells from patients with missed abortion.

  4. miR503 promotes tumour growth and invasion by directly targeting PDCD4.

  5. A novel mechanism of Pdcd4 action as a translation inhibitor and tumor suppressor has been proposed.

  6. Taken together, this study highlights an important role for miR (Montrer MLXIP Protéines)-23a/b as oncomiRs in gastric cancer through the inhibition of PDCD4 translation. These findings may shed new light on the molecular mechanism of gastric carcinogenesis and provide a new avenue for gastric cancer treatment.

  7. lncRNA CASC9 functions as an oncogene (Montrer RAB1A Protéines) by negatively regulating PDCD4 expression through recruiting EZH2 (Montrer EZH2 Protéines) and subsequently altering H3K27me3 level. Our study implicates lncRNA CASC9 as a valuable biomarker for ESCC diagnosis and prognosis.

  8. Exosomes derived from cisplatin-resistant OSCC cells transferred miR (Montrer MLXIP Protéines)-21 to oral squamous cell carcinoma (OSCC) parental cells and induced cisplatin resistance by targeting phosphatase and tensin homolog (PTEN) and programmed cell death 4 (PDCD4).

  9. These results indicate that the ROS (Montrer ROS1 Protéines)-STAT3 (Montrer STAT3 Protéines)-miR (Montrer MLXIP Protéines)-21-PDCD4 signaling axis plays an important role in arsenic -induced carcinogenesis.

  10. PDCD4 is expressed in the cytoplasm of glandular epithelium of control endometrium and varied during the cycle changes of endometrium. Compared with the proliferative phase of control endometrium, PDCD4 expression was down-regulated in proliferative phase of eutopic or ectopic endometrium. There was no cyclic variation of PDCD4 expression in eutopic endometrium of adenomyosis patients due to progesterone resistance.

Mouse (Murine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. In colorectal cancer tissues, the Sin1 (Montrer MAPKAP1 Protéines) protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 (Montrer MAPKAP1 Protéines) protein level but not mRNA level in colorectal cancer.

  2. -induced expression of PDCD4 is associated with increased beta cell death.

  3. miR (Montrer MLXIP Protéines)-155 not only directly inhibited SOCS1 (Montrer SOCS1 Protéines) expression, but also increased the expression of p-STAT (Montrer STAT1 Protéines) and PDCD4, as well as the production of proinflammation mediators IL-6 (Montrer IL6 Protéines) and TNF-alpha (Montrer TNF Protéines) in atherogenesis

  4. our data suggest that Pdcd4 as a crucial regulator in SGs (Montrer SKI Protéines) induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases.

  5. Pdcd4 deficiency attenuates atherosclerosis in hyperlipidemic mice in part through the upregulation of the anti-inflammatory cytokine IL-10 (Montrer IL10 Protéines).

  6. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (Montrer IL6 Protéines)/STAT3 (Montrer STAT3 Protéines) Pathway.

  7. Study found that miR-16 (Montrer GDE1 Protéines) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (Montrer NFKB1 Protéines) and MAPK (Montrer MAPK1 Protéines) pathways.

  8. Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.

  9. PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.

  10. In conclusion, miR (Montrer MLXIP Protéines)-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.

Zebrafish Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. miR (Montrer MYLIP Protéines)-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4

Pig (Porcine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB (Montrer NFKB1 Protéines)/ TNF-alpha (Montrer TNF Protéines) pathway in cardiomyocytes.

Profil protéine PDCD4

Profil protéine

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PDCD4

  • programmed cell death 4 (PDCD4)
  • programmed cell death 4 (Pdcd4)
  • programmed cell death 4b (pdcd4b)
  • programmed cell death 4 L homeolog (pdcd4.L)
  • programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4)
  • programmed cell death 4 (pdcd4)
  • cb45 Protéine
  • D19Ucla1 Protéine
  • Dug Protéine
  • h731 Protéine
  • Ma3 Protéine
  • MGC69337 Protéine
  • PDCD4 Protéine
  • sb:cb45 Protéine
  • Tis Protéine
  • wu:fc84b08 Protéine

Protein level used designations for PDCD4

neoplastic transformation inhibitor protein , nuclear antigen H731 , programmed cell death protein 4 , protein 197/15a , protein MA-3 , topoisomerase-inhibitor suppressed protein , death up-regulated gene protein , death-upregulated , protein I11/6 , programmed cell death 4 (neoplastic transformation inhibitor) , programmed cell death protein 4-like

GENE ID SPECIES
27250 Homo sapiens
18569 Mus musculus
64031 Rattus norvegicus
321061 Danio rerio
380222 Xenopus laevis
506724 Bos taurus
374191 Gallus gallus
407925 Xenopus (Silurana) tropicalis
450735 Pan troglodytes
477818 Canis lupus familiaris
695345 Macaca mulatta
100021762 Monodelphis domestica
100080517 Ornithorhynchus anatinus
100354557 Oryctolagus cuniculus
100413000 Callithrix jacchus
100469480 Ailuropoda melanoleuca
100584426 Nomascus leucogenys
100157112 Sus scrofa
100173014 Pongo abelii
100723476 Cavia porcellus
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