anti-Prolyl 4-Hydroxylase, alpha Polypeptide I (P4HA1) Anticorps

P4HA1 encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. De plus, nous expédions P4HA1 Kits (21) et P4HA1 Protéines (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
P4HA1 18451 Q60715
P4HA1 5033 P13674
P4HA1 64475 P54001
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Top anti-P4HA1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 72 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Chèvre Inconjugué ELISA, IHC, WB ABIN190847 (0.2µg/ml) staining of HEK293 cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL 2 to 3 Days
$289.00
Détails
Roussette (Chauve-souris) Chèvre Inconjugué ELISA, IHC, IHC (p), WB Human Skin (formalin-fixed, paraffin-embedded) stained with P4HA1 antibody ABIN461984 at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Human Spleen (formalin-fixed, paraffin-embedded) stained with P4HA1 antibody ABIN461984 at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg 11 to 14 Days
$484.00
Détails
Chien Chèvre Inconjugué EIA, IHC (p), WB Human Skin (formalin-fixed, paraffin-embedded) stained with P4HA1at 5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Spleen (formalin-fixed, paraffin-embedded) stained with P4HA1at 5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg 6 to 8 Days
$495.00
Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL 11 to 14 Days
$551.83
Détails
Cheval Lapin Inconjugué WB 100 μL 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of rat skin tissue, using P4HA1 antibody. ABIN6273063 at 1/100 staining Human lymph cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$390.77
Détails
Chien Chèvre Inconjugué WB   0.1 mg 11 Days
$462.00
Détails
Humain Lapin Inconjugué WB Western blot analysis in Ramos cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Détails

anti-P4HA1 Anticorps mieux référencés

  1. Human Polyclonal P4HA1 Primary Antibody pour ELISA, IHC (p) - ABIN252918 : Van Duyn Graham, Sweetwyne, Pallero, Murphy-Ullrich: Intracellular calreticulin regulates multiple steps in fibrillar collagen expression, trafficking, and processing into the extracellular matrix. dans The Journal of biological chemistry 2010 (PubMed)
    Show all 7 Pubmed References

  2. Human Polyclonal P4HA1 Primary Antibody pour WB - ABIN518574 : Ma, Guo, Liu, Liu, Hu, Sun, Yu, Lammi: Proteomic changes in articular cartilage of human endemic osteoarthritis in China. dans Proteomics 2011 (PubMed)
    Show all 2 Pubmed References

  3. Dog (Canine) Polyclonal P4HA1 Primary Antibody pour ELISA, WB - ABIN547864 : Wu, So, Davis-Dusenbery, Qi, Bloch, Shi, Lagna, Hata: Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. dans Molecular and cellular biology 2011 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre P4HA1 partenaires d’interaction

Mouse (Murine) Prolyl 4-Hydroxylase, alpha Polypeptide I (P4HA1) interaction partners

  1. N259 glycosylation induces P4HA1 to hydroxylate specific prolines in collagen 1 alpha 2, resulting in more pepsin-resistant collagen. Silencing STT3B or magnesium transporter 1 (MAGT1), the enzymes responsible for N259 glycosylation on P4HA1, significantly decreases hydroxylation of five prolines in collagen 1 alpha 2 and eight prolines in collagen 1alpha 1.

  2. Overexpression of P4Ha1 increased atherosclerotic plaque size.

  3. Impaired extracellular matrix is the primary cause of death of C-P4H-I+/-;C-P4H-II-/- growth plate chondrocytes.

  4. IL-6 destabilizes atherosclerotic plaques by downregulating P4Halpha1 via an RAF-MEK1/2-ERK1/2 MAPK and c-Jun pathway.

  5. C-P4H alpha(I) and alpha(II) mRNA levels were increased in hypoxic mouse chondrocytes in a manner dependent on HIF-1a.

Human Prolyl 4-Hydroxylase, alpha Polypeptide I (P4HA1) interaction partners

  1. Collagen prolyl 4-hydroxylase alpha 1 subunit (P4HA1) protein expression is induced in triple-negative breast cancer (TNBC) and HER2 positive breast cancer. Inhibition of P4HA1 sensitizes TNBC to the chemotherapeutic agent docetaxel and doxorubicin in xenografts and patient-derived models. Increased P4HA1 expression correlates with short relapse-free survival in TNBC patients who received chemotherapy.

  2. miR-122 inhibited migration, invasion, epithelial mesenchymal transition, and metastasis in peritoneal cavity of ovarian cancer cells by targeting P4HA1.

  3. High expression of P4HA1 was correlated with the malignancy of gliomas and could serve as a prognostic indicator for patients with high-grade gliomas

  4. Our study indicates that P4HA1 plays a pivotal role in the process of GSC-EC transdifferentiation and the structural formation of vascular BMs.

  5. we report compound heterozygous frameshift and splice site mutations in P4HA1 that impair but not abolish C-P4H alpha(I) activity. The maternal P4HA1 exon 12 splice donor site mutation causes an internally deleted C-P4H alpha(I) predicted to completely lack catalytic activity. two nucleic acid insertion in exon 9 results in a premature stop in the exon 9 P4HA1 splice form.

  6. Findings suggest that the catalytic domain of collagen prolyl 4-hydroxylases (CP4Hs) recognizes the cis conformation of the prolyl peptide bond.

  7. Thus, we conclude that miR-30e suppresses proliferation of hepatoma cells through targeting P4HA1 mRNA.

  8. Studies indicate P4HA1 copy number gain in a subset of metastatic prostate tumors and its expression is also regulated by microRNA-124.

  9. Overexpression of miR-122 markedly attenuated the expression of P4HA1 via targeting a binding site located at 3'-UTR of P4HA1 mRNA

  10. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts.

  11. IL-6 significantly downregulated P4Halpha1 expression in aortic smooth muscle cells

  12. analysis of the 2-His-1-Asp active-site motif in prolyl 4-hydroxylase

  13. These in vivo data demonstrated that smokers had thinner atherosclerotic cap thickness and lower levels of P4Halpha and collagen.

  14. Collagen prolyl 4-hydroxylase-alpha (I)mRNA is stabilized by interation of RNA-binding proteins hnRNP-A2/B1 with a U(16) element within the 3'-UTR

  15. positive (transforming growth factor beta1) and negative (cigarette smoking extract) regulators appear to influence the USF-E-box interaction and affect P4Halpha(I) expression

  16. Results suggest that the alteration of translational efficiency by nucleolin, which occurs through a hypoxia inducible factor independent pathway, is an important step in collagen prolyl 4-hydroxylase-alpha(I) regulation under hypoxia.

  17. In comparison with healthy cartilage, Osteoarthritis articular chondrocytes exhibit increased in vivo synthesis of collagen prolyl-4-hydroxylase type II, a pivotal enzyme in collagen triple helix formation.

  18. HIF-P4H, HIF-1alpha and HIF-2alpha are effective oxygen sensors

P4HA1 profil antigène

Profil protéine

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with P4HA1

  • prolyl 4-hydroxylase subunit alpha-1 (CpipJ_CPIJ000975) anticorps
  • prolyl 4-hydroxylase subunit alpha-1 (CpipJ_CPIJ017131) anticorps
  • prolyl 4-hydroxylase subunit alpha-1 (Tsp_03346) anticorps
  • prolyl 4-hydroxylase subunit alpha-1 (Tsp_03347) anticorps
  • prolyl 4-hydroxylase subunit alpha-1 (Tsp_15957) anticorps
  • prolyl 4-hydroxylase subunit alpha 1 (P4HA1) anticorps
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide (P4ha1) anticorps
  • prolyl 4-hydroxylase subunit alpha 1 (P4ha1) anticorps
  • AL022634 anticorps
  • P4ha anticorps
  • PHalphaI anticorps

Protein level used designations for P4HA1

prolyl 4-hydroxylase subunit alpha-1 , procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I , prolyl 4-hydroxylase alpha subunit , prolyl 4-hydroxylase, alpha I subunit , 4-PH alpha-1 , procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1 , C-P4Halpha(I) , collagen prolyl 4-hydroxylase alpha(I) , procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide

GENE ID SPECIES
6031971 Culex quinquefasciatus
6051272 Culex quinquefasciatus
10909085 Trichinella spiralis
10909086 Trichinella spiralis
10909998 Trichinella spiralis
100037299 Sus scrofa
450891 Pan troglodytes
18451 Mus musculus
5033 Homo sapiens
479242 Canis lupus familiaris
64475 Rattus norvegicus
518288 Bos taurus
423704 Gallus gallus
100172658 Pongo abelii
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