anti-Prolylcarboxypeptidase (PRCP) Anticorps

The protein encoded by PRCP is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. De plus, nous expédions Prolylcarboxypeptidase Kits (55) et Prolylcarboxypeptidase Protéines (11) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PRCP 72461 Q7TMR0
PRCP 5547 P42785
PRCP 293118  
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Top anti-Prolylcarboxypeptidase Anticorps sur anticorps-enligne.fr

Showing 10 out of 78 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Antigen: 0.2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat Anti-Rabbit IgG at 1: 5000; TMB staining; Read the data in Microplate Reader by 450nm Antigen: 0.2ug/100ul, Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000, Secondary: HRP conjugated Goat Anti-Rabbit IgG  at 1: 5000, TMB staining Read the data in MicroplateReader by 450nm. 100 μL Connectez-vous pour afficher 3 to 7 Days
$317.90
Détails
Humain Lapin Inconjugué ICC, IHC, WB Western Blot; Sample: Human Liver lysate; Primary Ab: 3µg/ml Rabbit Anti-Human PRCP Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) Figure. Western Blot; Sample: Recombinant PRCP, Human. 100 μg Connectez-vous pour afficher 13 to 16 Days
$332.00
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis in MDA-MB231,Hela cell line lysates (35ug/lane). PRCP Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extract of rat kidney cells, using PRCP antibody. 100 μL Connectez-vous pour afficher 11 to 13 Days
$366.77
Détails
Rat Lapin Inconjugué ICC, IHC, WB DAB staining on IHC-P; Samples: Rat Lung Tissue 100 μg Connectez-vous pour afficher 13 to 16 Days
$362.00
Détails
Rat Lapin Inconjugué WB Western blot analysis of extracts of rat kidney, using PRCP antibody (ABIN5972205) at 1/1000 dilution. 100 μL Connectez-vous pour afficher 11 to 16 Days
$412.19
Détails
Humain Lapin Inconjugué IF/ICC, IHC, IP, WB Western blot analysis of Human Liver lysate, using Human PRCP Antibody (3 µg/ml) and HRP-conjugated Goat Anti-Rabbit antibody ( Western blot analysis of recombinant Human PRCP. 100 μg Connectez-vous pour afficher 11 to 18 Days
$426.40
Détails
Humain Lapin Alexa Fluor 488 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$416.90
Détails
Humain Lapin Alexa Fluor 647 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$416.90
Détails
Humain Lapin Alexa Fluor 350 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$416.90
Détails

Plus d’anticorps contre Prolylcarboxypeptidase partenaires d’interaction

Mouse (Murine) Prolylcarboxypeptidase (PRCP) interaction partners

  1. PRCP in Agouti-related peptide neurons contributes to the modulation of alpha-MSH degradation, food intake and body weight.

  2. Prolylcarboxypeptidase (PRCP) converts AngII to Ang (1-7) but only at an acidic pH. Global PRCP deficiency causes heart and kidney alterations and a moderate rise in BP. PRCP is abundant in the kidney collecting tubules, where the prevailing pH is low. In collecting tubules, PRCP deficiency could result in impaired AngII degradation. Increased AngII at this nephron site stimulates Na reabsorption and increases BP.

  3. activity and expression in plasma and lung tissue stays unaffected in lung ischemia-reperfusion injury

  4. This study demonistrated that PRCP gene is broadly expressed in the brain.

  5. PRCP regulates cell growth, angiogenesis, and the response to vascular injury

  6. ACE2 metabolizes ANG II in the kidney at neutral and basic pH, while prolylcarboxypeptidase catalyzes the same reaction at acidic pH.

  7. PRCP is an important regulator of energy and glucose homeostasis since its deletion significantly improves metabolic parameters in mice exposed to both standard chow diet and high-fat diet

  8. analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors

  9. This study showed that PRCP mutant mice have a significant decrease in fat mass, although an increase in lean mass was also observed; reduced leptin levels and increased energy expenditure were also found.

  10. Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.

  11. PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-MSH1-13 levels.

Human Prolylcarboxypeptidase (PRCP) interaction partners

  1. Using multiple -omics approach, study validated key molecules, such as CAP1, SHC1 and PRCP, that might play a significant role in IgA nephropathy pathogenesis.

  2. For the first time, PRCP is identified as an apelin-cleaving enzyme.

  3. The decrease in PRCP levels in the first 24 h after stroke onset is associated with stroke severity and an unfavourable short-term stroke outcome

  4. PRCP1 interacts with plasma kallikrein (PK) at multiple sites for PK activation.

  5. The present results indicated PRCP rs7104980 can be considered as a marker for EH and Hap3 GAGCACTAACA (PRCP) and Hap16 TTTA (CMA1) might be associated with essential hypertension in Chinese Han population.

  6. PRCP regulates cell growth, angiogenesis, and the response to vascular injury

  7. analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors

  8. PRCP as a resistance factor for 4OHTAM resistance in estrogen receptor-positive breast cancer cells.

  9. A single peptide, with the sequence YPRPIHPA, as a novel substrate for PRCP in human cerebrospinal fluid.

  10. Purified PrCP yielded crystals belonging to space group R32, with unit-cell parameters a = b = 181.14, c = 240.13 A, that diffracted to better than 2.8 A resolution.

  11. A structure-based alignment with the previously undescribed structure of DPP7 illuminates the mechanism of orthogonal substrate specificity of PRCP and DPP7.

  12. Data suggest that the E112D polymorphism in the PRCP gene may be a useful genetic marker to predict the antihypertensive effect of short-term benazepril treatment in hypertensive patients.

  13. PRCP appears to be a HUVEC-associated prekallikrein activator.

  14. Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator.

  15. recombinant protein, identical to enzyme from human umbilical vein endothelial cells, is a prekallikrein activator.

  16. Prolylcarboxypepdiase E112D (rs2298668)D allele alone and jointly with chronic hypertension were associated with a significantly increased risk of preeclampsia

  17. role in regulation cardiovascular tone; proinflammatory agent

  18. These investigations showed that the C-terminal region of the rPRCP(40) contributes to PRCP's catalytic function, and provided additional experimental evidence for this suggestion.

Prolylcarboxypeptidase (PRCP) profil antigène

Profil protéine

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with PRCP

  • prolylcarboxypeptidase (prcp) anticorps
  • lysosomal Pro-X carboxypeptidase (LOC5579822) anticorps
  • prolylcarboxypeptidase (CpipJ_CPIJ006123) anticorps
  • prolylcarboxypeptidase (CpipJ_CPIJ006124) anticorps
  • prolylcarboxypeptidase (angiotensinase C) (Prcp) anticorps
  • prolylcarboxypeptidase (PRCP) anticorps
  • prolylcarboxypeptidase (Prcp) anticorps
  • prolylcarboxypeptidase (angiotensinase C) (prcp) anticorps
  • 2510048K03Rik anticorps
  • 2610104A14Rik anticorps
  • AI451719 anticorps
  • HUMPCP anticorps
  • MGC145178 anticorps
  • PCP anticorps
  • zgc:91816 anticorps

Protein level used designations for PRCP

prolylcarboxypeptidase , lysosomal Pro-X carboxypeptidase , proline carboxypeptidase , angiotensinase C , lysosomal carboxypeptidase C , prolylcarboxypeptidase isoform 1 preproprotein

GENE ID SPECIES
780095 Xenopus (Silurana) tropicalis
5579822 Aedes aegypti
6038068 Culex quinquefasciatus
6038069 Culex quinquefasciatus
72461 Mus musculus
5547 Homo sapiens
534927 Bos taurus
293118 Rattus norvegicus
476788 Canis lupus familiaris
100061830 Equus caballus
100734342 Cavia porcellus
436967 Danio rerio
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