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The protein encoded by PCSK7 belongs to the subtilisin-like proprotein convertase family.
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SPC7 is required for normal development of the eye and brain, possibly through processing BMPs, though other potential substrates cannot be excluded.
PCSK7 is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.
Our present data suggest that PCSK7 as well as PCSK9 (Montrer PCSK9 Anticorps) may be associated with lipids, especially triglyceride, and may serve as a candidate for a new drug target to treat lipid abnormality syndromes.
PCSK7 rs236918 C allele is a risk factor for cirrhosis development in Italian patients with HFE-Hemochromatosis (Montrer HFE Anticorps).
Furin (Montrer FURIN Anticorps) and PC7 siRNAs induced HIF-1alpha (Montrer HIF1A Anticorps) protein by increasing its translation, resulting in upregulation of VEGF-A (Montrer VEGFA Anticorps).
The data suggest that PCSK7 genotypes may interact with dietary CHO (Montrer COL11A1 Anticorps) intake on changes in insulin (Montrer INS Anticorps) sensitivity in the white Americans.
Results demonstrate that PCSK7 variation is a strong host risk factor of liver cirrhosis in hereditary hemochromatosis (Montrer HFE Anticorps) patients homozygous for HFE (Montrer HFE Anticorps) C282Y.
overexpression of PCs, furin (Montrer FURIN Anticorps) and PC5 (Montrer PCSK5 Anticorps), but not PC7, which are all expressed in SMC (Montrer DYM Anticorps), increase PKGI (Montrer PRKG1 Anticorps) cleavage in a dose-dependent manner
Among the PC family members, only furin (Montrer FURIN Anticorps) activates hepcidin (Montrer HAMP Anticorps) in hepatocytes, and uniquely the full-length membrane-bound PC7 can directly shed hTfR1 by cleavage at Arg100
PCSK7 is involved in sTfR (Montrer TFRC Anticorps) generation and iron homeostasis.
Proprotein convertase PC7 enhances the activation of the EGF receptor (Montrer EGFR Anticorps) pathway through processing of the EGF (Montrer EGF Anticorps) precursor.
PC7 is distinct from other proprotein convertases in its zymogen activation, subcellular localization, and trafficking.
PC7 has a critical role in normal processing of cholecystokinin (Montrer CCK Anticorps) in mouse brain
PC7 and the related proteases Furin (Montrer FURIN Anticorps) and Pace4 (Montrer PCSK6 Anticorps) regulate E-cadherin (Montrer CDH1 Anticorps) function during blastocyst formation.
Data show that BDNF (Montrer BDNF Anticorps) and PC7 mRNAs are colocalized in hippocampus and amygdala and that mature BDNF (Montrer BDNF Anticorps) protein levels are reduced in these brain areas in proprotein convertase PC7 knockout mice.
in binding VEGFR-2 (Montrer KDR Anticorps), furin (Montrer FURIN Anticorps) and PC5 (Montrer PCSK5 Anticorps) promote cleavage of N-and C-terminal VEGF-D (Montrer Figf Anticorps) propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.
proprotein convertase PC7
, proprotein convertase subtilisin/kexin type 7
, proprotein convertase subtilisin/kexin type 7-like
, lymphoma proprotein convertase
, prohormone convertase 7
, prohormone convertase PC7
, proprotein convertase 7
, proprotein convertase 8
, subtilisin/kexin-like protease PC7
, subtilisin-like proprotein convertase 7