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PTGIS encodes a member of the cytochrome P450 superfamily of enzymes. De plus, nous expédions Prostaglandin I2 (Prostacyclin) Synthase Kits (38) et Prostaglandin I2 (Prostacyclin) Synthase Protéines (8) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 70 products:
Human Polyclonal PTGIS Primary Antibody pour ELISA, WB - ABIN562513
Gurgul-Convey, Hanzelka, Lenzen: Mechanism of prostacyclin-induced potentiation of glucose-induced insulin secretion. dans Endocrinology 2012
In examining the tumor suppressor PTGIS as a potential biomarker for treatment with either 5-Aza-dC or TSA (Montrer PRDX2 Anticorps), 5-Aza-dC effectively stabilized cell cycling, restricted genetic instability and derepressed PTGIS expression
Based on the predicted crystal structure of CYP8A1( *)5 using the Molecular Operating Environment platform, the distance from CYP8A1 Cys441 to the heme was altered with a significantly changed binding free energy for the mutant protein.
results indicate that PGIS expression was associated with radiotherapy efficiency
Type-2 diabetes is associated with higher COX-2 (Montrer COX2 Anticorps) expression, but lower eNOS (Montrer NOS3 Anticorps) and PGIS expression in subcutaneous arteries.
In a case-control study unaffected carriers of a BMPR2 mutation, linked to pulmonary artery hypertension (PAH), were most often found to have prostacyclin synthase promoter sequence variants, which were thought to protect against PAH.
These findings suggest that PGIS is induced by hypoxia and regulates the expression of VEGF (Montrer VEGFA Anticorps) in fibroblasts.
High PTGIS expression is associated with colorectal cancer hepatic metastasis.
The CC genotype of C1117A polymorphism is associated with higher risk of LM-CAD (Montrer CAD Anticorps)
Overexpression of PTGIS is associated with liver metastasis in colon cancer.
diabetes preferentially increases PGIS nitration that is associated with excessive vascular inflammation in atherosclerotic carotid arteries from patients with type 2 diabetes
Prostacyclin synthase and prostaglandin E synthase (Montrer PTGES Anticorps)-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.
Cyclooxygenase-2 (Montrer PTGS2 Anticorps)-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor (Montrer F3 Anticorps) in a sirtuin-1 (Montrer SIRT1 Anticorps)-dependent-manner.
CD40 ligand (Montrer CD40LG Anticorps) might contribute to the initiation and progression of atherosclerosis by increasing activity of prostacyclin synthase.
Sepiapterin not only reversed the effects of high glucose on both angiotensin II-induced relaxation and PGI(2 (Montrer PTGIR Anticorps)) release but also abolished high-glucose-enhanced PGIS nitration.
Alpha(2)-adrenoreceptor activation is required for coupling heart rate to central inspiratory drive during acute hypoxia, and PGI(2 (Montrer PTGIR Anticorps)) is required to enhance the inhibition of sympathoactivation.
The results provide strong evidence that the protective effects of COX-2 (Montrer COX2 Anticorps) within the liver are mediated through the production of PGE (Montrer LIPF Anticorps)(2) and PGI(2 (Montrer PTGIR Anticorps)), which exert anti-inflammatory functions.
Endothelial PGI (Montrer BGN Anticorps) synthase-mediated prostacyclin contributes to renal protection against endotoxemia-related acute kidney injury.
identify PGI(2)-prostaglandin I2 receptor (Montrer PTGIR Anticorps) as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4 (Montrer CD4 Anticorps)(+) Th2 cells into the inflammatory site
COX-1 (Montrer PTGS1 Anticorps) contributes to the enhanced formation of both PGI(2 (Montrer PTGIR Anticorps)) and TXA(2 (Montrer TBXA2R Anticorps)) in atherosclerosis, and to the development of the disease
PGIS/ IP transgenic animals with lung-specific PPARgamma (Montrer PPARG Anticorps) overexpression also developed fewer lung tumors.
crystal structures of ligand-free, inhibitor (minoxidil)-bound and substrate analog U51605-bound PGIS
Disturbances in prostacyclin synthase and its receptor may lead to disruption of the oviductal environment and, in turn, perturbed development of embryos and their transport to the uterus.
Prostacyclin synthase is differentially expressed in the endometrium of cyclic and pregnant gilts resulting in higher PGI(2 (Montrer PTGIR Anticorps)) synthesis in pregnant animals
CRP (Montrer CRP Anticorps) stimulates superoxide production and the subsequent formation of peroxynitrite from basal released nitric oxide compromises PGI(2 (Montrer PTGIR Anticorps)) synthesis.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
cytochrome P450, family 8, subfamily A, polypeptide 1
, prostacyclin synthase
, prostaglandin I2 synthase
, prostaglandin I2 (prostacyclin) synthase like
, prostaglandin I2 (prostacyclin) synthase
, cytochrome P450 8A1