Protein Arginine Methyltransferase 6 Protéines (PRMT6)

The protein encoded by PRMT6 belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. De plus, nous expédions Protein Arginine Methyltransferase 6 Anticorps (110) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PRMT6 55170 Q96LA8
Rat PRMT6 PRMT6 295384  
PRMT6 99890 Q6NZB1
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Top Protein Arginine Methyltransferase 6 Protéines sur anticorps-enligne.fr

Showing 9 out of 11 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Human Cells Humain DYKDDDDK Tag,His tag 50 μg Connectez-vous pour afficher 20 to 21 Days
$382.80
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Levure Xenopus tropicalis His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,920.50
Détails
Levure Poisson Zèbre His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,948.00
Détails
Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,030.50
Détails
Baculovirus Humain DYKDDDDK Tag PRMT6 activity assay. HMT assay measuring the activity of Recombinant PRMT6. Activity was detected by fluorography. Recombinant PRMT6 protein gel. PRMT6 protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Connectez-vous pour afficher 1 to 2 Days
$495.83
Détails

PRMT6 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , ,
, , , ,
Mouse (Murine)

Protein Arginine Methyltransferase 6 Protéines mieux référencés

  1. Human PRMT6 Protein expressed in Human Cells - ABIN2004214 : Hyllus, Stein, Schnabel, Schiltz, Imhof, Dou, Hsieh, Bauer: PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. dans Genes & development 2007 (PubMed)
    Show all 4 Pubmed References

Plus protéines pour Protein Arginine Methyltransferase 6 (PRMT6) partenaires d'interaction

Human Protein Arginine Methyltransferase 6 (PRMT6) interaction partners

  1. PRMT6 negatively regulates DNA methylation (Montrer HELLS Protéines) in cancer. PRMT6 overexpression impairs chromatin association of UHRF1 (Montrer UHRF1 Protéines), an accessory factor of DNMT1 (Montrer DNMT1 Protéines), resulting in passive DNA demethylation.

  2. Data suggest that histone-arginine N-methyltransferase PRMT6 (PRMT6) plays an oncogenic role in prostate cancer (PCa (Montrer FLVCR1 Protéines)) and predicts for more clinically aggressive disease, constituting a potential target for patients with Prostate cancer (CRPC).

  3. PRMT6, which was down-regulated by androgen receptors and influenced cell migration and apoptosis of germ cells, could play a potentially important role in spermatogenesis.

  4. PRMT6 methylates tumor cell p21 (Montrer CDKN1A Protéines) at arginine 156 and promotes phosphorylation of threonine 145 on p21 (Montrer CDKN1A Protéines), increasing the cytoplasmic localization of p21 (Montrer CDKN1A Protéines) and inducing resistance to anticancer drugs.

  5. PRMT6 influences PRC-mediated gene silencing at the rostral HOXA genes locus.

  6. Data show that HIV-1 Tat (Montrer TAT Protéines) methylation by protein arginine methyltransferase 6 (PRMT6) can inhibit nucleolar retention.

  7. N terminus is methylated by PRMT6 and that this critically affects the functions of pUL69 for efficient mRNA export and replication of human cytomegalovirus.

  8. TBL1 (Montrer TBL1X Protéines) is required to protect GPS2 (Montrer GPS2 Protéines) from degradation, with methylation of GPS2 (Montrer GPS2 Protéines) by arginine methyltransferase PRMT6 regulating the interaction with TBL1 (Montrer TBL1X Protéines) and inhibiting proteasome-dependent degradation.

  9. PRMT6 mediates cigarette smoke extract induced apoptosis and inflammation through H3R2me2a in HUVECs.

  10. PRMT6 specifically interacts with ERalpha (Montrer ESR1 Protéines) at its ligand-binding domain.

Zebrafish Protein Arginine Methyltransferase 6 (PRMT6) interaction partners

  1. these results suggest that maternal Prmt6 is essential to early zebrafish development by directly repressing gadd45alphaa.

Mouse (Murine) Protein Arginine Methyltransferase 6 (PRMT6) interaction partners

  1. Six crystal structures of PRMT6 from Mus (Montrer TRPV6 Protéines) musculus, solved and refined at 1.34 A for the highest resolution structure are described.

  2. Prmt6 is important for embryonic stem cell pluripotency and self-renewal.

  3. The findings define a new regulator of p53 (Montrer TP53 Protéines) transcriptional regulation and define a role for PRMT6 and arginine methylation in cellular senescence.

Profil protéine Protein Arginine Methyltransferase 6 (PRMT6)

Profil protéine

The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.

Gene names and symbols associated with PRMT6

  • Arginine methyltransferase 6 (Art6)
  • protein arginine methyltransferase 6 (PRMT6)
  • protein arginine methyltransferase 6 S homeolog (prmt6.S)
  • arginine N-methyltransferase, type I (PRMT6)
  • protein arginine methyltransferase 6 (prmt6)
  • protein arginine methyltransferase 6 (Prmt6)
  • protein arginine N-methyltransferase 6 (Prmt6)
  • ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 6 Protéine
  • ATPRMT6 Protéine
  • AW124876 Protéine
  • BB233495 Protéine
  • CG9927 Protéine
  • DART6 Protéine
  • DKFZp459B1431 Protéine
  • Dmel\\CG9927 Protéine
  • hrmt1l6 Protéine
  • hrmt6 Protéine
  • im:6908706 Protéine
  • PRMT6 Protéine
  • protein arginine methyltransferase 6 Protéine

Protein level used designations for PRMT6

arginine methyltransferase 6 , CG9927-PA , Art6-PA , protein arginine methyltransferase 6 , HMT1 hnRNP methyltransferase-like 6 , Histone-arginine N-methyltransferase PRMT6 , protein arginine N-methyltransferase 6 , arginine N-methyltransferase, type I , heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 , histone-arginine N-methyltransferase PRMT6

GENE ID SPECIES
41699 Drosophila melanogaster
457073 Pan troglodytes
447344 Xenopus laevis
694284 Macaca mulatta
821541 Arabidopsis thaliana
5067888 Leishmania infantum JPCM5
100145123 Xenopus (Silurana) tropicalis
100172901 Pongo abelii
55170 Homo sapiens
295384 Rattus norvegicus
490133 Canis lupus familiaris
540228 Bos taurus
100156688 Sus scrofa
448867 Danio rerio
99890 Mus musculus
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