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vitamin K-dependent zymogen that acts as a serine protease upon activation; catalyzes the inactivation of blood coagulation cofactors Va and VIIIa. De plus, nous expédions PROC Kits (42) et et beaucoup plus de produits pour cette protéine.
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Cow (Bovine) Polyclonal PROC Primary Antibody pour EIA, RIA - ABIN613777
Satou, Nishi, Hishinuma, Hosoda, Kangawa, Sugimoto: Identification of activated protein C as a ghrelin endopeptidase in bovine plasma. dans The Journal of endocrinology 2014
Data show that activated protein C signals via protease activated receptors PAR2 (Montrer F2RL1 Anticorps)/PAR3 (Montrer F2RL2 Anticorps) to expand Treg cells, mitigating the disease in mice.
insulin (Montrer INS Anticorps) and aPC (Montrer APC Anticorps) converge on a common spliced-X-box binding protein-1 (Montrer XBP1 Anticorps) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.
loss of the convertase furin (Montrer FURIN Anticorps) or PC5 (Montrer PCSK5 Anticorps)/6 in hepatocytes results in a approximately 30% decrease in APC (Montrer APC Anticorps) levels, with no significant contribution from PACE4 (Montrer PCSK6 Anticorps). We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (Montrer F2 Anticorps) activation.
APC (Montrer APC Anticorps) modifies pulmonary fibrosis by limiting thrombin (Montrer F2 Anticorps)-dependent macrophage recruitment.
Small interfering RNA-mediated silencing of protein C in apolipoprotein E (Montrer APOE Anticorps)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.
These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (Montrer APC Anticorps)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (Montrer APC Anticorps) in the context of endotoxemia and infection
activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.
impaired EPCR (Montrer PROCR Anticorps)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis
SOD prevents thrombomodulin (Montrer THBD Anticorps) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.
sPLA2 (Montrer PLA2G2A Anticorps)-V plays a thrombogenic role by impairing the ability of EPCR (Montrer PROCR Anticorps) to promote protein C activation.
vitamin K-dependent zymogen that acts as a serine protease upon activation; catalyzes the inactivation of blood coagulation cofactors Va and VIIIa
anticoagulant protein C
, autoprothrombin IIA
, blood coagulation factor XIV
, inactivator of coagulation factors Va, VIII
, vitamin K-dependent protein C