Protein Kinase, CGMP-Dependent, Type I Protéines
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II).
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Protein Kinase, CGMP-Dependent, Type I (PRKG1) (AA 2-671) protein (His tag) Protein
Protein Kinase, CGMP-Dependent, Type I (PRKG1) (AA 2-671) protein (His tag) Protein
Protein Kinase, CGMP-Dependent, Type I (PRKG1) (AA 1-686) protein (GST tag) Protein
Protein Kinase, CGMP-Dependent, Type I (PRKG1) (AA 1-686) protein (GST tag) Protein
Protein Kinase, CGMP-Dependent, Type I (PRKG1) (AA 73-170) protein (GST tag) Protein
Protein Kinase, CGMP-Dependent, Type I (PRKG1) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag) Protein
Protein Kinase, CGMP-Dependent, Type I (PRKG1) (AA 2-686) protein (His tag) Protein
Protein Kinase, CGMP-Dependent, Type I (PRKG1) Protéine Protein
Protein Kinase, CGMP-Dependent, Type I (PRKG1) (Active) protein (GST tag) Protein
Protein Kinase, CGMP-Dependent, Type I (PRKG1) (AA 324-671) (Active) protein (GST tag) Protein
Protein Kinase, CGMP-Dependent, Type I (PRKG1) Protéine Protein
Protein Kinase, CGMP-Dependent, Type I (PRKG1) Protéine Protein
Profil protéine Protein Kinase, CGMP-Dependent, Type I (PRKG1)
Profil protéine
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
Gene names and symbols associated with PRKG1
- protein kinase, cGMP-dependent, type Ia (prkg1a) anticorps
- protein kinase, cGMP-dependent, type I (PRKG1) anticorps
- protein kinase, cGMP-dependent, type I (prkg1) anticorps
- protein kinase, cGMP-dependent, type 1 (Prkg1) anticorps
- protein kinase, cGMP-dependent, type I (Prkg1) anticorps
- 1 anticorps
- AW125416 anticorps
- cGK anticorps
- cGK1 anticorps
- cGK 1 anticorps
- CGKI anticorps
- cGKI-alpha anticorps
- cGKI-beta anticorps
- Gm19690 anticorps
- PKG anticorps
- Pkgi anticorps
- prkg1 anticorps
- Prkg1b anticorps
- Prkg1beta anticorps
- Prkgr1b anticorps
- zgc:63955 anticorps
Protein level used designations for PRKG1
cGMP-dependent protein kinase 1 , protein kinase, cGMP-dependent, type I , cGMP-dependent protein kinase 1, beta isozyme , cGMP-dependent protein kinase I alpha , cGK I alpha , cGMP-dependent protein kinase 1-like , cGMP dependent protein kinase type 1 , protein kinase, cGMP-dependent, regulatory, type I, beta , CGK 1 alpha , cGK 1 beta , cGK1 , cGKI-alpha , cGMP-dependent protein kinase 1, alpha isozyme , cGMP-dependent protein kinase I , cGK 1 , PKG1 alpha , cGMP-dependent protein kinase type 1 alpha , cGMP-dependent protein kinase type I beta
| GENE ID | SPECIES |
|---|---|
| 394005 | Danio rerio |
| 744467 | Pan troglodytes |
| 100049290 | Oryzias latipes |
| 100388016 | Callithrix jacchus |
| 54286 | Rattus norvegicus |
| 5592 | Homo sapiens |
| 282004 | Bos taurus |
| 19091 | Mus musculus |
| 100008694 | Oryctolagus cuniculus |
| 733640 | Sus scrofa |
| 423682 | Gallus gallus |