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The protein encoded by PRKCDBP was identified as a binding protein of the protein kinase C, delta (PRKCD). De plus, nous expédions Protein Kinase C, delta Binding Protein Kits (7) et Protein Kinase C, delta Binding Protein Protéines (5) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal PRKCDBP Primary Antibody pour ELISA, IHC - ABIN4347315
McMahon, Zajicek, Li, Peyton, Minna, Hernandez, Luby-Phelps, Anderson: SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function. dans The EMBO journal 2009
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Human Polyclonal PRKCDBP Primary Antibody pour ELISA, WB - ABIN4347316
Bastiani, Liu, Hill, Jedrychowski, Nixon, Lo, Abankwa, Luetterforst, Fernandez-Rojo, Breen, Gygi, Vinten, Walser, North, Hancock, Pilch, Parton: MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. dans The Journal of cell biology 2009
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Human Polyclonal PRKCDBP Primary Antibody pour ELISA, WB - ABIN566689
Bai, Deng, Li, Wang, An, Deli, Gao, Xie, Dai, Cong: Down-regulation of the cavin family proteins in breast cancer. dans Journal of cellular biochemistry 2011
PRKCDBP variants may be risk factors of major depressive disorder.
Rather than forming a single coat complex containing the three cavin family members, single-molecule analysis reveals an exquisite specificity of interactions between cavin1, cavin2 and cavin3.
cavin3 is recruited to the caveolae coat by cavin1 to interact with caveolin1 and regulate the duration time of caveolae at the plasma membrane.
in vivo consequences of cavin-3 knockout are increased lactate production and cachexia
These results demonstrate that mucosal expression of PRKCDBP correlated strongly with TNF-alpha expression in UC patients and that infliximab therapy resulted in profound reductions in both PRKCDBP and TNF-alpha.
we found loss at 11p15 to be a marker for triple-negative breast cancer and breast cancer brain metastases and PRKCDBP to be a potential target gene in this locus.
individuals with the variant homozygous CC genotype of PRKCDBP rs1051992 were at higher risk for developing endometrial cancer, but this genotype was a favorable prognostic factor once cancer was present
The cavin family protein Polymerase 1 and transcript release factor, SRBC and serum deprivation response protein were down regulated in breast cancer cell lines and breast tumor tissue.
Data indicate that PRKCDBP expression was hardly detectable in 29 of 80 (36%) primary tumors and 11 of 19 (58%) cell lines.
Our data demonstrate that epigenetic inactivation of hSRBC due to aberrant promoter hypermethylation is a common event and might be implicated in human ovarian tumorigenesis.
Data show low or moderate methylation was found in seven selected genes BAD, BBC3, CAV1, CDK2AP1, NPM1, PRKCDBP and THEM4.
hSRBC is a candidate tumor suppressor gene involved in lung cancer pathogenesis, where expression is frequently inactivated by methylation and other mechanisms
hSRBC is a novel tumor suppressor whose epigenetic inactivation contributes to the malignant progression of gastric tumors, in part, through attenuated p53 response to stresses.
Results suggest that SRBC (sdr-related gene product that binds to c-kinase) and two other family members [PTRF (Pol I and transcription release factor) and SDPR] function as caveolin adapter molecules that regulate caveolae function.
Human SRBC is located within the 11p15.5-p15.4 tumor suppressor region and is inactivated in breast and lung cancers.
studies establish a role of cavin-3 in the formation of caveolae in vivo but also show that the physiological consequences of cavin-3 ablation are modest
The roles of cavins 2 and 3 in caveolar morphogenesis in vivo, are reported.
The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein.
protein kinase C, delta binding protein
, protein kinase C delta-binding protein
, sdr-related gene product that binds to c-kinase
, serum deprivation response factor-related gene product that binds to C-kinase
, D3T-inducible gene 2 protein
, PKC-delta binding protein
, dithiolethione-inducible gene 2 protein
, dithiolethione-inducible gene-2
, sdr-elated gene product that binds to c-kinase