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PACSIN2 is a member of the protein kinase C and casein kinase substrate in neurons family.
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Human Polyclonal PACSIN2 Primary Antibody pour IF, IHC (p) - ABIN392666
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... dans Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 7 Pubmed References
To our knowledge, this is the first study showing PACSIN2 genotype association with hematological toxicity in ALL patients undergoing maintenance therapy.
FlnA (Montrer FLNA Anticorps) binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.
our results provide new insights into the mechanism of cellular intoxication by TcdA and the role of PACSIN2 in endocytosis.
proposed a packing model for the assembly of PACSIN 2 on membrane, where the proteins are connected by tip-to-tip and wedge loop-mediated lateral interactions on the surface of membrane to generate various diameter tubules
PACSIN2 phosphorylation decreases its membrane-binding activity, thereby decreasing its stabilizing effect on caveolae and triggering dynamin (Montrer DNM1 Anticorps)-mediated removal of caveolae.
PC1 modulates actin cytoskeleton rearrangements and directional cell migration through the Pacsin 2/N-Wasp complex.
Cooperation of MICAL-L1 (Montrer MICALL1 Anticorps), pacsin 2 (syndapin2), and phosphatidic acid in tubular recycling endosome biogenesis.
These data indicate that polymorphism in PACSIN2 significantly modulates TPMT (Montrer TPMT Anticorps) activity and influences the risk of GI toxicity associated with mercaptopurine therapy.
a novel role for the F-BAR-domain protein PACSIN2 in regulating EGF receptor (Montrer EGFR Anticorps) surface levels and EGF (Montrer EGF Anticorps)-induced downstream signaling.
Data identify the BAR-domain protein PACSIN2 as a Rac1 interactor that regulates Rac1-mediated cell spreading and migration.
Pacsin 2 contributes to kidney development and repair in a nephron-specific manner.
syndapin II binds to both flat and curved membranes in vivo and that it plays an important role in caveolar shaping, a role that it shares with PTRF/cavin 1 (Montrer PTRF Anticorps).
Study shows that PACSIN2 is involved in the regulation of gastrulation, possibly through regulating cell adhesion.
This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants.
protein kinase C and casein kinase substrate in neurons 2
, protein kinase C and casein kinase substrate in neurons protein 2-like
, cytoplasmic phosphoprotein PACSIN2
, protein kinase C and casein kinase substrate in neurons protein 2
, syndapin 2
, syndapin II
, Syndapin II
, focal adhesion protein of 52 kDa
, SdpIIsyndapin II
, protein kinase C and casein kinase substrate in neurons 2 protein
, synaptic dynamin-associated protein II