Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A Protéines (PPP1R14A)

The protein encoded by PPP1R14A belongs to the protein phosphatase 1 (PP1) inhibitor family. De plus, nous expédions Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A Anticorps (60) et Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A Kits (1) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PPP1R14A 94274 Q96A00
PPP1R14A 114004 Q99MC0
PPP1R14A 68458 Q91VC7
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Top Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A Protéines sur anticorps-enligne.fr

Showing 10 out of 13 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Escherichia coli (E. coli) Humain His tag Validation with Western Blot 10 μg Connectez-vous pour afficher 8 to 11 Days
$394.90
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 15 to 19 Days
$492.31
Détails
Levure Sanglier His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,321.00
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,321.00
Détails
Escherichia coli (E. coli) Humain His tag   10 μg Connectez-vous pour afficher 15 to 16 Days
$225.00
Détails
Escherichia coli (E. coli) Humain His tag   1 mg Connectez-vous pour afficher 2 to 3 Days
$4,000.00
Détails

PPP1R14A Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Rat (Rattus)

Mouse (Murine)

Plus protéines pour Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) partenaires d'interaction

Zebrafish Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) interaction partners

  1. Hoxb1b is likely to directly regulate ppp1r14al expression in rhombomere 4. Furthermore, ppp1r14al is essential for establishment of the earliest hindbrain signaling-center in rhombomere 4 by regulating expression of fgf3 (Montrer FGF3 Protéines).

Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) interaction partners

  1. CPI-17 drives Ras activity and tumorigenesis in melanomas in a two-fold way; inactivation of the tumor suppressor merlin (Montrer NF2 Protéines) and activation of the growth promoting ERM (Montrer ETV5 Protéines) family.

  2. The authors call the mutual sequestration mechanism through which pCPI-17 and myosin light-chain phosphatase interact inhibition by unfair competition: myosin light-chain phosphatase protects pCPI-17 from other phosphatases, while pCPI-17 blocks other substrates from the active site of myosin light-chain phosphatase.

  3. Study finds that CPI-17 (PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A, 17 kDa) is not expressed in the healthy peripheral nervous system or in nontumour pathologies of the peripheral nervous system. CPI-17 up-regulation, however, is observed in over 90% of schwannomas, but not in neurofibroma and only rarely in malignant peripheral nerve sheath tumour.

  4. CPI-17 has a role in restoring skin homoeostasis in cutaneous field of cancerization lesions

  5. analysis of the interaction between plakoglobin (Montrer JUP Protéines) and CPI-17, which is affected by the phosphorylation status of CPI-17 in human lung microvascular endothelial cells

  6. The N-terminal 21-residue tail domain of CPI-17 is necessary for nuclear localization. Phospho-mimetic Asp (Montrer ASIP Protéines)-substitution of CPI-17 at Ser12 attenuates the nuclear import.

  7. The study characterized the CPI-17 promoter and identified binding sites for GATA-6 (Montrer GATA6 Protéines) and nuclear factor kappa B (NF-kappaB (Montrer NFKB1 Protéines)).

  8. a novel signaling cascade that links RhoA (Montrer RHOA Protéines)-mediated calcium sensitivity to MEF2 (Montrer MEF2A Protéines)-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK (Montrer MAPK14 Protéines), PP1alpha (Montrer PPP1CA Protéines), and CPI-17.

  9. RACK1 (Montrer GNB2L1 Protéines) may play a role in PKC (Montrer PRRT2 Protéines)/CPI-17 signaling pathway.

  10. cAMP/PKA regulates the endothelial barrier via inhibition of the contractile machinery, mainly by the activation of MLCP via inhibition of CPI-17 and RhoA (Montrer RHOA Protéines)/Rock.

Mouse (Murine) Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) interaction partners

  1. Enhanced vasorelaxation in early endotoxemia is mediated by redox signaling through PKG-1alpha but in later endotoxemia by myosin phosphatase isoform shifts enhancing sensitivity to NO/cGMP as well as smooth muscle atrophy.

  2. The study characterized the CPI-17 promoter and identified binding sites for GATA-6 (Montrer GATA6 Protéines) and nuclear factor kappa B (NF-kappaB (Montrer NFKB1 Protéines)).

  3. a novel signaling cascade that links RhoA (Montrer RHOA Protéines)-mediated calcium sensitivity to MEF2 (Montrer MEF2C Protéines)-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK (Montrer MAPK14 Protéines), PP1alpha (Montrer PPP1CA Protéines), and CPI-17.

  4. Data suggest that CPI-17 and both conventional and novel PKC isozymes contribute to the phasic and tonic contractile components of BALB/c colonic circular smooth muscle.

  5. Organ-specific mechanisms involving MYPT1 (Montrer PPP1R12A Protéines), M-RIP, and CPI-17 are critical to regulating basal LC20 (Montrer MYL9 Protéines) phosphorylation in gastrointestinal smooth muscles.

  6. calcium-independent phospholipase A2beta has a role in high glucose-induced activation of RhoA (Montrer RHOA Protéines), Rho kinase (Montrer ROCK2 Protéines), and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals

  7. distribution of mouse and rat PPP1R14A was more specific and different from that of humans

  8. concluded that actions downstream of cGMP/PKG (Montrer PRKG1 Protéines) can reverse PKC-mediated phosphorylation of CPI-17 and Ca(2 (Montrer CA2 Protéines)+) sensitization in smooth muscle

  9. findings suggest that CPI-17 was downregulated during intestinal inflammation and that TNF-alpha (Montrer TNF Protéines) plays a central role in this process. Downregulation of CPI-17 may play a role in motility impairments in inflammation.

  10. CPI-17 expression is reversibly controlled in response to the phenotype transition of smooth muscle cells that restricts the signal to differentiated smooth muscle cells and particular cell types.

Pig (Porcine) Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) interaction partners

  1. This study examined the protein expression and spatial-temporal distribution of PKCalpha (Montrer PKCa Protéines) and CPI-17 in intact smooth muscle tissues.

Profil protéine Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A)

Profil protéine

The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with PPP1R14A

  • protein phosphatase 1 regulatory inhibitor subunit 14A L homeolog (ppp1r14a.L)
  • protein phosphatase 1 regulatory inhibitor subunit 14A (ppp1r14a)
  • protein phosphatase 1, regulatory (inhibitor) subunit 14Aa (ppp1r14aa)
  • protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A)
  • protein phosphatase 1, regulatory (inhibitor) subunit 14A (PPP1R14A)
  • protein phosphatase 1, regulatory (inhibitor) subunit 14A (Ppp1r14a)
  • 1110001M11Rik Protéine
  • CPI-17 Protéine
  • Cpi17 Protéine
  • im:7147597 Protéine
  • MGC81874 Protéine
  • PPP1INL Protéine
  • PPP1R14A Protéine
  • zgc:110700 Protéine

Protein level used designations for PPP1R14A

protein phosphatase 1, regulatory (inhibitor) subunit 14A , protein phosphatase 1 regulatory subunit 14A , 17 kDa PKC-potentiated inhibitory protein of PP1 , 17-KDa protein , 17-kDa PKC-potentiated inhibitory protein of PP1 , PKC-potentiated inhibitory protein of PP1 , protein kinase C-potentiated inhibitor protein of 17 kDa , CPI-17

GENE ID SPECIES
447728 Xenopus laevis
493331 Xenopus (Silurana) tropicalis
550561 Danio rerio
612579 Canis lupus familiaris
615348 Bos taurus
641304 Ovis aries
747250 Pan troglodytes
94274 Homo sapiens
114004 Rattus norvegicus
68458 Mus musculus
397610 Sus scrofa
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