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The protein encoded by PPP1R16B is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. De plus, nous expédions Protein Phosphatase 1, Regulatory Subunit 16B Anticorps (33) et Protein Phosphatase 1, Regulatory Subunit 16B Protéines (4) et beaucoup plus de produits pour cette protéine.
These data confirmed the barrier-protective role of TIMAP
NF2 (Montrer NF2 Kits ELISA) localizes in nucleus when Ser518 is not phosphorylated, while phosphorylated form is present in cytoplasm and plasma membrane. Data suggest that binding of NF2 (Montrer NF2 Kits ELISA) to TIMAP and EBP50 (Montrer SLC9A3R1 Kits ELISA) is critical in nuclear localization of NF2 (Montrer NF2 Kits ELISA). (NF2 (Montrer NF2 Kits ELISA) = neurofibromin 2 (Montrer NF2 Kits ELISA); TIMAP = TGF-beta-inhibited membrane-associated protein; EBP50 (Montrer SLC9A3R1 Kits ELISA) = Ezrin (Montrer EZR Kits ELISA)-Radixin (Montrer RDX Kits ELISA)-Mosein binding phosphoprotein 50)
phosphorylation of TIMAP on Ser331 by PKC represents a new mechanism of endothelial barrier regulation, through the inhibition of phospho-ERM dephosphorylation
Results indicate that PKC-phosphorylated ECE-1 (Montrer ECE1 Kits ELISA) is a TIMAP-PP1c substrate and this phosphatase complex has an important role in endothelin-1 (Montrer EDN1 Kits ELISA) production of EC through the regulation of ECE-1 (Montrer ECE1 Kits ELISA) activity.
ROCK phosphorylated eEF1A1 (Montrer EEF1A1 Kits ELISA) is a novel substrate for TIMAP-PP1 (Montrer PPA1 Kits ELISA) underlining the complex regulatory role of TIMAP in the endothelium.
TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt (Montrer AKT1 Kits ELISA) inhibition in human glomerular endothelial cells.
Data suggest that double-thiophosphorylation of TIMAP has minor effect on its binding ability to PP1c, but considerably attenuates its inhibitory effect on the activity of PP1c.
TIMAP, a novel CAAX box protein regulated by TGF-beta1 (Montrer TGFB1 Kits ELISA) and expressed in endothelial cells.
involvement of TIMAP in PKA-mediated moesin (Montrer MSN Kits ELISA) dephosphorylation and the importance of this dephosphorylation in TIMAP-mediated endothelial cell barrier protection
TIMAP can modify protein phosphorylation independent of its function as a PP1c regulatory subunit, namely by masking phosphorylation sites of binding partners like PP1c and LAMR1 (Montrer RPSA Kits ELISA).
TIMAP is a target for PKA-primed GSK-3beta (Montrer GSK3b Kits ELISA)-mediated phosphorylation. This phosphorylation controls TIMAP association and activity of PP1c
The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
CAAX box protein TIMAP
, TGF-beta-inhibited membrane-associated protein
, protein phosphatase 1 regulatory inhibitor subunit 16B
, whn-dependent transcript 4
, ankyrin repeat domain protein 4
, ankyrin repeat domain-containing protein 4
, protein phosphatase 1, regulatory (inhibitor) subunit 16B