Protein Phosphatase 4, Catalytic Subunit (PPP4C) Kits ELISA

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. De plus, nous expédions PPP4C Anticorps (115) et PPP4C Protéines (11) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Humain PPP4C PPP4C 5531 P60510
Anti-Souris PPP4C PPP4C 56420 P97470
Anti-Rat PPP4C PPP4C 171366 Q5BJ92
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Plus Kits ELISA pour PPP4C partenaires d'interaction

Zebrafish Protein Phosphatase 4, Catalytic Subunit (PPP4C) interaction partners

  1. Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos

Human Protein Phosphatase 4, Catalytic Subunit (PPP4C) interaction partners

  1. Knockdown of Alpha4 preferentially impacts the expression of PP4c and PP6c (Montrer PPP6C Kits ELISA) compared to expression levels of PP2Ac.

  2. Data show that protein phosphatase 4 catalytic subunit (PP4C) knockdown decreases glioma cell proliferation.

  3. mutual regulatory mechanisms exist between PP4 (Montrer ANXA5 Kits ELISA) and SAF-A (Montrer HNRNPU Kits ELISA). Interactions between PP4 (Montrer ANXA5 Kits ELISA) and SAF-A (Montrer HNRNPU Kits ELISA) played a role in prometaphase/metaphase transition.

  4. These data suggested a potential role of PP4C in tumor progression.

  5. Stathmin plays an essential role of in Merkel cell polyomavirus small tumor antigen-mediated microtubule destabilization and cell motility and this process is regulated by cellular phosphatase catalytic subunit of protein phosphatase 4.

  6. PP4 (Montrer ANXA5 Kits ELISA) and Wip1 (Montrer PPM1D Kits ELISA) are differentially required to counteract the p53 (Montrer TP53 Kits ELISA)-dependent cell cycle arrest in G1 and G2, by antagonizing early or late p53 (Montrer TP53 Kits ELISA)-mediated responses, respectively

  7. Results show PP4C as a fostriecin-sensitive phosphatase and demonstrate that the suppression of PP4C triggers mitotic slippage/apoptosis.

  8. Data indicate that the major phosphatase responsible for dephosphorylation of of BAF (Montrer BANF1 Kits ELISA) Ser (Montrer SIGLEC1 Kits ELISA)-4 to be protein phosphatase 4 catalytic subunit.

  9. Recombinant gamma-tubulin (Montrer TUBG1 Kits ELISA) can be phosphorylated by Cdk1 (Montrer CDK1 Kits ELISA)-cyclin B or Brsk1 (Montrer BRSK1 Kits ELISA) and dephosphorylated by Ppp4c-R2-R3A in vitro.

  10. PP4c is a key regulator of cortical development that changes the orientation of progenitor division responsible for the transition between symmetric and asymmetric cell division.

Mouse (Murine) Protein Phosphatase 4, Catalytic Subunit (PPP4C) interaction partners

  1. LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function.

  2. T cell-specific ablation of PP4 (Montrer ANXA5 Kits ELISA) resulted in defective adaptive immunity, impaired T cell homeostatic expansion, and inefficient T cell proliferation.

  3. Data show that protein phosphatase 4 (PP4 (Montrer ANXA5 Kits ELISA)) is an important regulator in inflammatory related insulin (Montrer INS Kits ELISA) resistance.

  4. Thus, serine/threonine phosphatase PP4 (Montrer ANXA5 Kits ELISA) functions as a novel feedback negative regulator of RNA virus-triggered innate immunity.

  5. Taken together, our results establish a novel role for PP4 (Montrer ANXA5 Kits ELISA) in CSR (Montrer SCARA3 Kits ELISA), and reveal crucial functions for PP4 (Montrer ANXA5 Kits ELISA) in the maintenance of genomic stability, GC formation, and B cell-mediated immune responses.

  6. PP4 (Montrer ANXA5 Kits ELISA) overexpression was observed to lead to a decreased pACC1Ser79/ACC1 (Montrer ACACA Kits ELISA) ratio and subsequently an increased intracellular triglyceride content in mouse primary hepatocytes.

  7. Mammalian SMEK/PP4C proteins are involved in the regulation of hepatic glucose metabolism through dephosphorylation of CRTC2 (Montrer CRTC2 Kits ELISA).

  8. Protein phosphatase 4 has a role in apoptosis.

  9. PP4 is essential for thymocyte development and pre-TCR signaling

  10. PP4 (Montrer ANXA5 Kits ELISA) negatively regulated LPS (Montrer TLR4 Kits ELISA)-induced and TRAF6 (Montrer TRAF6 Kits ELISA)-mediated NF-kappaB (Montrer NFKB1 Kits ELISA) activation by inhibiting the ubiquitination of TRAF6 (Montrer TRAF6 Kits ELISA).

PPP4C profil antigène

Antigen Summary

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Gene names and symbols associated with PPP4C

  • protein phosphatase 4 catalytic subunit (ppp4c) anticorps
  • protein phosphatase 4, catalytic subunit a (ppp4ca) anticorps
  • protein phosphatase 4 catalytic subunit (PPP4C) anticorps
  • protein phosphatase 4, catalytic subunit (Ppp4c) anticorps
  • protein phosphatase 4 catalytic subunit S homeolog (ppp4c.S) anticorps
  • 1110002D08Rik anticorps
  • AU016079 anticorps
  • gc:56413 anticorps
  • MGC75928 anticorps
  • PP4 anticorps
  • PP4C anticorps
  • PP4C-A anticorps
  • PPH3 anticorps
  • PPP4 anticorps
  • ppp4c anticorps
  • Ppx anticorps
  • wu:fd05e08 anticorps
  • zgc:56413 anticorps

Protein level used designations for PPP4C

protein phosphatase 4, catalytic subunit , catalytic subunit , serine/threonine-protein phosphatase 4 catalytic subunit A , PP-X , protein phosphatase 4 (formerly X), catalytic subunit , protein phosphatase X, catalytic subunit , serine/threonine-protein phosphatase 4 catalytic subunit , PP4C , pp4 , protein phosphatase X

GENE ID SPECIES
394540 Xenopus (Silurana) tropicalis
100003080 Danio rerio
5531 Homo sapiens
540398 Bos taurus
56420 Mus musculus
171366 Rattus norvegicus
489947 Canis lupus familiaris
100009163 Oryctolagus cuniculus
432334 Xenopus laevis
100173513 Pongo abelii
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