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PPP6C encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. De plus, nous expédions Protein Phosphatase 6, Catalytic Subunit Anticorps (73) et Protein Phosphatase 6, Catalytic Subunit Protéines (5) et beaucoup plus de produits pour cette protéine.
findings define the WHIP (Montrer WRNIP1 Kits ELISA)-TRIM14 (Montrer TRIM14 Kits ELISA)-PPP6C mitochondrial signalosome required for RIG-I (Montrer DDX58 Kits ELISA)-mediated innate antiviral immunity.
Knockdown of Alpha4 preferentially impacts the expression of PP4c (Montrer PPP4C Kits ELISA) and PP6c compared to expression levels of PP2Ac.
findings suggest that BRCA1 is a novel modulator of PP6 signalling via its interaction with ANKRD28.
Data show 408 phosphopeptides on 272 proteins that increased and 298 phosphopeptides on 220 proteins that decreased in phosphorylation upon catalytic subunit of rotein phosphatase 6 (PP6c) depletion in mitotic cells.
Protein phosphatase 6 ( (Montrer NFKB1 Kits ELISA)ppp6c), a ne (Montrer MLXIP Kits ELISA)gative regulator that restricts the G1 to S phase progression, is diminished in human psoriatic epidermis and is directly targeted by miR-31.
PP6 is involved in a diverse set of biological pathways.
These results suggest that human PP6 interacts with and positively regulates the activity of the influenza A virus RNA-dependent RNA polymerase.
PP6C mutations have distinct functional and clinical consequences in melanoma, and confer sensitivity to Aurora A kinase (Montrer AURKA Kits ELISA) inhibitors.
PP6c associates with E-cadherin (Montrer CDH1 Kits ELISA) in adherens junctions and is required to oppose casein kinase-1 (Montrer CSNK1A1 Kits ELISA) to maintain cell surface localization of E-cadherin (Montrer CDH1 Kits ELISA).
Findings support the view that formation of micronuclei rather than chromosome instability alone explains how loss of PPP6C, and more generally mitotic spindle and centrosome defects, can act as drivers for genome instability in melanoma.
the Ppp6c phosphatase domain is indispensable for mouse embryogenesis after implantation.
findings uncover a hitherto unknown role for PP6 as an indispensable regulator of oocyte meiosis and female fertility.
Data identify NF-kappaB (Montrer NFKB1 Kits ELISA)-induced miR (Montrer MLXIP Kits ELISA)-31 and its target, ppp6c, as critical factors for the hyperproliferation of epidermis in psoriasis.
Ppp6c deficiency predisposes mice to skin carcinogenesis initiated by DMBA.
Ppp6c deficiency underlies molecular events that drive outgrowth of initiated keratinocytes harboring UVB-induced mutated p53 (Montrer TP53 Kits ELISA)
Our studies demonstrate that PP6 acts as a critical negative regulator of naive T cell homeostasis
PP6 regulates the sensitivity of GBM cells to radiation, and suggest small molecules disrupting or inhibiting PP6 association with DNA-PK is a potential radiosensitizer for GBM.
alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A and PP6 [PP6]
This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X.
serine/threonine protein phosphatase catalytic subunit
, serine/threonine-protein phosphatase 6 catalytic subunit
, protein phosphatase V
, protein phosphatase 6, catalytic subunit
, serine/threonine-protein phosphatase 6 catalytic subunit-like