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PRC1 encodes a protein that is involved in cytokinesis. De plus, nous expédions PRC1 Protéines (6) et PRC1 Kits (4) et beaucoup plus de produits pour cette protéine.
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Results mechanistically explain how the two conserved, essential midzone proteins PRC1 and Xklp1 cooperate to constitute a minimal protein module capable of dynamically organizing the core structure of the central anaphase spindle.
We discuss targeting PRC1 within the complementary approaches of either normalizing chromosomal instability in aneuploid cancers or creating chromosomal chaos in genomically stable cancers to induce apoptosis.
PRC1 mRNA and protein expressions were upregulated in lung adenocarcinoma tissues. PRC1 expression was significantly correlated with the Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling pathway.
We finally confirmed that PRC1 is a novel downstream target of piperlongumine in gastric cancer. Our findings supported the oncogenic role of PRC1 in gastric carcinogenesis. PRC1 might serve as a prognostic biomarker and potential therapeutic target for gastric carcinoma.
These findings suggest that the identified APLP2 (Montrer APLP2 Anticorps), RRM2 (Montrer RRM2 Anticorps), and PRC1 signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium.
Near-atomic cryo-electron microscopy structure of PRC1 bound to the microtubule has been described.
study reveals that UbE2E1 (Montrer UBE2E1 Anticorps) is an in vivo E2 for the PRC1 ligase complex and thus plays an important role in the regulation of H2A Lys (Montrer LYZ Anticorps)-119 monoubiquitination
PRC1 is a novel Wnt (Montrer WNT2 Anticorps) target that functions in a positive feedback loop that reinforces Wnt (Montrer WNT2 Anticorps) signalling to promote early Hepatocellular Carcinoma recurrence.
PRC1 rs10520699 and rs11852999 polymorphisms were associated with PRC1 transcript levels, but not with patients survival.
These findings suggest that the aberrant expression of PRC1 may predict biochemical recurrence in men with prostate cancer highlighting its potential as a prognostic marker of this malignancy.
PP2A (Montrer PPP2R4 Anticorps)-B55 (Montrer MINK1 Anticorps) dephosphorylates PRC1 at the metaphase to anaphase transition. This activity is regulated by the Greatwall (MASTL (Montrer MASTL Anticorps)) kinase and its substrate ENSA (Montrer ENSA Anticorps), explaining the timing of PRC1 activation in anaphase.
Authors analyzed whether elevated levels of the polycomb (Montrer CBX2 Anticorps) repressor complex 1 (PRC1) components Bmi1 (Montrer BMI1 Anticorps) and Ring1b (Montrer RNF2 Anticorps) and their catalyzed histone modification H2AK119ub in ADMs and tumor cells, are responsible for the mediation of acinar gene silencing.
Here, the authors discover that the histone H2AK119 E3 ubiquitin ligase (Montrer MUL1 Anticorps) activity of Polycomb (Montrer CBX2 Anticorps) repressive complex 1 (PRC1) is defined by the composition of its catalytic subunits and is highly regulated by RYBP (Montrer RYBP Anticorps)/YAF2 (Montrer YAF2 Anticorps)-dependent stimulation.
Here, by combining live-cell single-molecule tracking (SMT) and genetic engineering, the authors reveal that H3K27me3 contributes significantly to the targeting of Cbx7 (Montrer CBX7 Anticorps)-PRC1 complex to chromatin.
Pcgf6 (Montrer PCGF6 Anticorps) is essential for recruitment of PRC1.6 to chromatin. Our results reveal a previously uncharacterized, H2AK119ub1-independent chromatin assembly associated with PRC1.6 complex
The data reveal how the interplay between PRC1, ncRNA and Mediator complexes controls pluripotency and cellular differentiation.
our findings show that PRC1 mediates gene repression by combining multiple and different effector mechanisms, of which H2A ubiquitination is a major contributor
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants.
protein regulator of cytokinesis 1
, anaphase spindle elongation 1 homolog
, protein regulating cytokinesis 1