Protein Regulator of Cytokinesis 1 (PRC1) Kits ELISA

PRC1 encodes a protein that is involved in cytokinesis. De plus, nous expédions PRC1 Anticorps (54) et PRC1 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
PRC1 9055 O43663
PRC1 233406 Q99K43
Anti-Rat PRC1 PRC1 308761  
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Top PRC1 Kits ELISA sur

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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Souris < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
Humain < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days

Plus Kits ELISA pour PRC1 partenaires d'interaction

Xenopus laevis Protein Regulator of Cytokinesis 1 (PRC1) interaction partners

  1. Results mechanistically explain how the two conserved, essential midzone proteins PRC1 and Xklp1 cooperate to constitute a minimal protein module capable of dynamically organizing the core structure of the central anaphase spindle.

Human Protein Regulator of Cytokinesis 1 (PRC1) interaction partners

  1. findings pave the way to identify sequence-specific DNA-binding proteins implicated in the targeting of mammalian polycomb repressive complex 1 complexes and provide novel link between polycomb repression and cancer

  2. Here, the authors show that the collective activity of PRC1 and Kif4A results in relative microtubule sliding and concurrent end-tag formation on antiparallel microtubules.

  3. BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation.

  4. PRC1 was identified as a type 2 diabetes susceptibility gene. PRC1 plays a role in insulin secretion in vitro.

  5. We discuss targeting PRC1 within the complementary approaches of either normalizing chromosomal instability in aneuploid cancers or creating chromosomal chaos in genomically stable cancers to induce apoptosis.

  6. PRC1 mRNA and protein expressions were upregulated in lung adenocarcinoma tissues. PRC1 expression was significantly correlated with the Wnt/beta-catenin signaling pathway.

  7. We finally confirmed that PRC1 is a novel downstream target of piperlongumine in gastric cancer. Our findings supported the oncogenic role of PRC1 in gastric carcinogenesis. PRC1 might serve as a prognostic biomarker and potential therapeutic target for gastric carcinoma.

  8. These findings suggest that the identified APLP2, RRM2, and PRC1 signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium.

  9. Near-atomic cryo-electron microscopy structure of PRC1 bound to the microtubule has been described.

  10. study reveals that UbE2E1 is an in vivo E2 for the PRC1 ligase complex and thus plays an important role in the regulation of H2A Lys-119 monoubiquitination

  11. PRC1 is a novel Wnt target that functions in a positive feedback loop that reinforces Wnt signalling to promote early Hepatocellular Carcinoma recurrence.

  12. PRC1 rs10520699 and rs11852999 polymorphisms were associated with PRC1 transcript levels, but not with patients survival.

  13. These findings suggest that the aberrant expression of PRC1 may predict biochemical recurrence in men with prostate cancer highlighting its potential as a prognostic marker of this malignancy.

  14. PP2A-B55 dephosphorylates PRC1 at the metaphase to anaphase transition. This activity is regulated by the Greatwall (MASTL) kinase and its substrate ENSA, explaining the timing of PRC1 activation in anaphase.

  15. PRC1 complexes isolated from human cells contain multiple kinesins KIF4A, Kif20A, KIF23 and KIF14.

  16. PRC1 is a docking partner for the Polo kinase Plk1 in anaphase cells. During metaphase this is inhibited by Cdk1-cyclin B phosphorylation at T470 and T481.

  17. The presence of CBX4 or CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.

  18. Study finds that frictional forces increase nonlinearly with microtubule-associated proteins (MAP) velocity across microtubules and depend on filament polarity, with NuMA's friction being lower when moving toward minus ends, EB1's lower toward plus ends, and PRC1's exhibiting no directional preference.

  19. Studies reveal how interactions between the conserved nonmotor MAP, PRC1, and the motor protein, kinesin-4, generate filament length-dependent tags at microtubule plus ends. PRC1 tags ends of microtubules in dividing cells and the size of these tags increases linearly with filament length.

  20. Different PRC1 paralog family members have nonredundant and locus-specific gene regulatory activities that are essential for human hematopoiesis.

Mouse (Murine) Protein Regulator of Cytokinesis 1 (PRC1) interaction partners

  1. Results indicate that Ub-independent mode of repression by PRC1 plays a key role in mammalian development during cell fate restriction.

  2. Authors analyzed whether elevated levels of the polycomb repressor complex 1 (PRC1) components Bmi1 and Ring1b and their catalyzed histone modification H2AK119ub in ADMs and tumor cells, are responsible for the mediation of acinar gene silencing.

  3. Here, the authors discover that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex 1 (PRC1) is defined by the composition of its catalytic subunits and is highly regulated by RYBP/YAF2-dependent stimulation.

  4. Here, by combining live-cell single-molecule tracking (SMT) and genetic engineering, the authors reveal that H3K27me3 contributes significantly to the targeting of Cbx7-PRC1 complex to chromatin.

  5. Pcgf6 is essential for recruitment of PRC1.6 to chromatin. Our results reveal a previously uncharacterized, H2AK119ub1-independent chromatin assembly associated with PRC1.6 complex

  6. The data reveal how the interplay between PRC1, ncRNA and Mediator complexes controls pluripotency and cellular differentiation.

  7. our findings show that PRC1 mediates gene repression by combining multiple and different effector mechanisms, of which H2A ubiquitination is a major contributor

PRC1 profil antigène

Antigen Summary

This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PRC1

  • protein regulator of cytokinesis 1 (PRC1) anticorps
  • protein regulator of cytokinesis 1a (prc1a) anticorps
  • protein regulator of cytokinesis 1 S homeolog (prc1.S) anticorps
  • protein regulator of cytokinesis 1b (prc1b) anticorps
  • protein regulator of cytokinesis 1 (CNC07120) anticorps
  • protein regulator of cytokinesis 1 (prc1) anticorps
  • protein regulator of cytokinesis 1 (Prc1) anticorps
  • ASE1 anticorps
  • cb212 anticorps
  • D7Ertd348e anticorps
  • MGC68845 anticorps
  • prc1 anticorps
  • prc1l anticorps
  • zgc:55664 anticorps
  • zgc:55982 anticorps
  • zgc:86918 anticorps

Protein level used designations for PRC1

protein regulator of cytokinesis 1 , anaphase spindle elongation 1 homolog , protein regulating cytokinesis 1

100069001 Equus caballus
259194 Danio rerio
380562 Xenopus laevis
393203 Danio rerio
770336 Gallus gallus
3256388 Cryptococcus neoformans var. neoformans JEC21
100012273 Monodelphis domestica
100216075 Xenopus (Silurana) tropicalis
9055 Homo sapiens
233406 Mus musculus
308761 Rattus norvegicus
767818 Bos taurus
488742 Canis lupus familiaris
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