anti-Proteoglycan 4 (PRG4) Anticorps

The protein encoded by PRG4 is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. De plus, nous expédions Proteoglycan 4 Kits (26) et Proteoglycan 4 Protéines (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PRG4 10216 Q92954
PRG4 289104  
PRG4 96875 Q9JM99
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Top anti-Proteoglycan 4 Anticorps sur anticorps-enligne.fr

Showing 10 out of 38 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Human Serum. 100 μg Connectez-vous pour afficher 13 to 16 Days
$350.00
Détails
Humain Lapin Inconjugué ICC, IHC (p), WB 50 μg Connectez-vous pour afficher 7 to 9 Days
$727.83
Détails
Humain Lapin Inconjugué WB Figure 1 shows a Western blot of Lubricin in human recombinant Lubricin using ABIN261551. Western Blot: Proteoglycan 4 Antibody [ABIN2615513] - Analysis of 3ug of non-reduced human synovial fluid per well onto a SDS-PAGE gel. 0.1 mg Connectez-vous pour afficher 7 to 9 Days
$444.19
Détails
Humain Souris Inconjugué ELISA, WB 100 μg Connectez-vous pour afficher 7 to 9 Days
$537.17
Détails
Humain Lapin Inconjugué IF (p), IHC (p) Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. 100 μL Connectez-vous pour afficher 3 to 7 Days
$306.90
Détails
Humain Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 7 to 9 Days
$390.50
Détails
Humain Chèvre Inconjugué ELISA   100 μg Connectez-vous pour afficher 7 to 9 Days
$507.83
Détails
Humain Chèvre Inconjugué ELISA   100 μg Connectez-vous pour afficher 6 to 7 Days
$242.88
Détails
Humain Lapin Alexa Fluor 647 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$405.90
Détails
Humain Lapin Alexa Fluor 488 IF (p)   100 μL Connectez-vous pour afficher 14 to 21 Days
$405.90
Détails

PRG4 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-Proteoglycan 4 Anticorps mieux référencés

  1. Human Polyclonal Proteoglycan 4 Primary Antibody pour ELISA - ABIN449721 : Jay, Torres, Warman, Laderer, Breuer: The role of lubricin in the mechanical behavior of synovial fluid. dans Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)

Plus d’anticorps contre Proteoglycan 4 partenaires d’interaction

Human Proteoglycan 4 (PRG4) interaction partners

  1. Intra-articular injection of human PRG4 in vivo in Prg4-/- mice prevented caspase-3 (Montrer CASP3 Anticorps) activation in superficial zone chondrocytes and was associated with a modest decrease in whole joint friction.

  2. PRG4 plays an important anti-inflammatory role in regulating osteoarthritis synoviocyte proliferation.

  3. IL6 (Montrer IL6 Anticorps) and PRG4 represent potential novel tissue biomarkers of disease severity and prognosis in conjunctival fibrosis after glaucoma surgery.

  4. adult talar cartilage increases both PRG4 release and biosynthetic activity as immediate cellular response to injury

  5. Double knockdown of PRG4 and IL-24 (Montrer IL24 Anticorps) did not inhibit myxoid liposarcoma (MLS)- cell growth, and single knockdown of PRG4 remarkably increased IL-24 (Montrer IL24 Anticorps) expression. These results suggest that the growth inhibitory effect of PRG4 knockdown is caused by induction of IL-24 (Montrer IL24 Anticorps) expression, and PRG4 may contribute to maintain MLS cell growth through repression of IL-24 (Montrer IL24 Anticorps) expression.

  6. lubricin expression may typify adaptive and neoplastic changes along a pathway toward fibroblast-like synoviocytes

  7. PRG4 binds to TLR2 and TLR4 (Montrer TLR4 Anticorps) and this binding mediates a novel anti-inflammatory role for PRG4.

  8. Cartilage derived from MSCs expressed lubricin protein both in vitro and in vivo

  9. PRG4 is a novel putative ligand for CD44 (Montrer CD44 Anticorps) and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44 (Montrer CD44 Anticorps)-mediated mechanism.

  10. The O-glycomap of lubricin, a novel mucin (Montrer SLC13A2 Anticorps) responsible for joint lubrication, has been identified by site-specific glycopeptide analysis.

Cow (Bovine) Proteoglycan 4 (PRG4) interaction partners

  1. TGF-beta1 (Montrer TGFB1 Anticorps) stimulated lubricin secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta (Montrer TGFB1 Anticorps) treatment. It is noteworthy that the daily treatment of TGF-beta1 (Montrer TGFB1 Anticorps) increased lubricin much higher compared with twice-a-week treatment.

  2. the intermolecular disulfide-bonded multimeric structure of PRG4 is important for its ability to adsorb to a cartilage surface and function as a boundary lubricant.

  3. The present investigation provides novel insights into the role of the Wnt (Montrer WNT2 Anticorps) signalling pathways in SZP accumulation in synoviocytes and their roles in the homeostasis of normal joints.

  4. The important role of PRG4 in reducing friction in the tissues and compartments of the knee/stifle joint.

  5. The role of cell surface glycosaminoglycans (GAGs) during TGF-beta1 (Montrer TGFB1 Anticorps) stimulation of SZP/lubricin/PRG4 in superficial zone articular chondrocytes, was investigated.

  6. Lubricin expression in explant cartilage was also suppressed under hypoxia

  7. SZP production is dependent on the functional cytoskeleton, and Rho GTPases contribute to SZP accumulation by modulating the actions of TGFbeta (Montrer TGFB1 Anticorps).

  8. the combined treatment with TGF-beta1 (Montrer TGFB1 Anticorps) and BMP-7 (Montrer BMP7 Anticorps) or treatment first with TGF-beta1 (Montrer TGFB1 Anticorps) followed by BMP-7 (Montrer BMP7 Anticorps) was more effective than other treatment groups in both chondrogenic differentiation and SZP secretion.

  9. A variety of monomeric PRG4 proteins and a disulfide-bonded dimer/multimer are secreted by chondrocytes in bovine cartilage explants.

  10. proteoglycan 4 expression and chondrocyte phenotype is invluenced by matrix molecules and alginate-embedded zonal chondrocytes and mesenchymal stem cells

Mouse (Murine) Proteoglycan 4 (PRG4) interaction partners

  1. Intra-articular injection of human PRG4 in vivo in Prg4-/- mice prevented caspase-3 (Montrer CASP3 Anticorps) activation in superficial zone chondrocytes and was associated with a modest decrease in whole joint friction.

  2. Data indicate that Prg4 is needed for the temporomandibular joint integrity and long-term postnatal function. In its absence, progenitor cells near presumptive articular layer and disc undergo ectopic chondrogenesis and generate ectopic cartilage, possibly driven by aberrant activation of Hh signaling.

  3. Prg4 is needed for TMJ disc integrity and function and its absence leads to ectopic chondrogenesis and cartilage formation in conjunction with abnormal BMP signaling.

  4. Discs from Prg4 null mice had a significantly smaller mean transverse disc area, with a significantly larger proportion of this area occupied by the nucleus pulposus.

  5. PRG4 is a novel putative ligand for CD44 (Montrer CD44 Anticorps) and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44 (Montrer CD44 Anticorps)-mediated mechanism.

  6. Prg4-expressing cells at the embryonic joint surface serve as a progenitor population for deeper layers of mature articular cartilage. Prg4 is expressed by superficial chondrocytes in young mice but in deeper regions of articular cartilage in older mice.

  7. findings confirm the importance of lubricin in intrasynovial tendon lubrication.

  8. mechanical motion may induce Prg4 expression in the superficial zone of articular cartilage

  9. changes in synovial fluid proteins and PRG4 concentrations upon joint loading are mediated by cells within the joint, and that these changes may be used as quantitative indicators for the intensity and duration of acute joint loading

  10. Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva and its deficiency may play a role in promoting corneal damage.

Pig (Porcine) Proteoglycan 4 (PRG4) interaction partners

  1. Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva.

Rabbit Proteoglycan 4 (PRG4) interaction partners

  1. Lubricin/PRG4 gene expression was increased in medial collateral ligaments after 14 weeks of menopause in adult rabbits.

  2. The mRNA expression levels for lubricin/proteoglycan 4 (PRG4) and tissue inhibitor of metalloproteinase-3 (Montrer TIMP3 Anticorps) increase with aging.

Proteoglycan 4 (PRG4) profil antigène

Profil protéine

The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Proteoglycan 4 (PRG4) Anticorps

  • proteoglycan 4 (PRG4) anticorps
  • proteoglycan 4 (Prg4) anticorps
  • proteoglycan 4b (prg4b) anticorps
  • proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) (Prg4) anticorps
  • bG174L6.2 anticorps
  • CACP anticorps
  • DOL54 anticorps
  • HAPO anticorps
  • JCAP anticorps
  • lubricin anticorps
  • MSF anticorps
  • PRG4 anticorps
  • si:dkey-97o5.3 anticorps
  • SZP anticorps
  • zgc:122988 anticorps

Protein level used designations for anti-Proteoglycan 4 (PRG4) Anticorps

articular superficial zone protein , bG174L6.2 (MSF: megakaryocyte stimulating factor ) , lubricin , megakaryocyte stimulating factor , megakaryocyte-stimulating factor , superficial zone proteoglycan , MLL septin-like fusion , proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome) , proteoglycan 4 , p53-responsive gene 4 , proteoglycan 3

GENE ID SPECIES
10216 Homo sapiens
280867 Bos taurus
289104 Rattus norvegicus
553377 Danio rerio
768493 Gallus gallus
100034016 Equus caballus
100294585 Ovis aries
96875 Mus musculus
664716 Canis lupus familiaris
100518683 Sus scrofa
100347000 Oryctolagus cuniculus
100716004 Cavia porcellus
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