anti-Proteolipid Protein 1 (PLP1) Anticorps

PLP1 encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. De plus, nous expédions Proteolipid Protein 1 Kits (33) et Proteolipid Protein 1 Protéines (6) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PLP1 5354 P60201
PLP1 24943 P60203
PLP1 18823 P60202
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Top anti-Proteolipid Protein 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 65 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB WB Suggested Anti-PLP1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  721_B cell lysate Immunohistochemistry with Brain, cerebellum tissue at an antibody concentration of 5µg/ml using anti-PLP1 antibody (ARP33843_P050) 100 μL 2 to 3 Days
$319.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-PLP1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Hela cell lysate Host:  Mouse  Target Name:  PLP1  Sample Tissue:  Mouse Heart  Antibody Dilution:  1ug/ml 100 μL 2 to 3 Days
$319.00
Détails
Boeuf (Vache) Souris Inconjugué FACS, IHC (fro), IF, IHC (p), WB   0.1 mg 6 to 8 Days
$390.50
Détails
Humain Lapin Inconjugué IP, WB PLP1 MaxPab rabbit polyclonal antibody. Western Blot analysis of PLP1 expression in mouse testis. PLP1 MaxPab rabbit polyclonal antibody. Western Blot analysis of PLP1 expression in A-431. 100 μL 11 to 12 Days
$425.71
Détails
Boeuf (Vache) Souris Inconjugué IHC, IHC (fro), IHC (p), WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with PLP1 antibody ABIN364261 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with PLP1 antibody ABIN364261 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 0.05 mg 11 to 14 Days
$484.00
Détails
Humain Souris Inconjugué ICC, IHC, IHC (fro), IHC (p), WB Anti-PLP1 antibody IHC staining of human brain cerebellum, neuropil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1103681 dilution 10 ug/ml. Anti-PLP1 antibody IHC of human brain cerebellum, neuropil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml. 50 μg 11 to 14 Days
$727.83
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p), WB Anti-PLP1 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959011 concentration 5 ug/ml. Anti-PLP1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. ... 100 μL 11 to 14 Days
$727.83
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. Formalin-fixed and paraffin embedded rat brain labeled with Anti-Myelin PLP Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
$317.90
Détails
Humain Souris Inconjugué ELISA, WB 100 μg 11 to 14 Days
$551.83
Détails
Boeuf (Vache) Souris Inconjugué IHC, WB 0.05 mg 2 to 3 Days
$618.75
Détails

anti-Proteolipid Protein 1 Anticorps mieux référencés

  1. Mouse (Murine) Polyclonal PLP1 Primary Antibody pour ICC, WB - ABIN261597 : Horiuchi, Maezawa, Itoh, Wakayama, Jin, Itoh, Decarli: Amyloid β1-42 oligomer inhibits myelin sheet formation in vitro. dans Neurobiology of aging 2012 (PubMed)
    Show all 4 Pubmed References

  2. Cow (Bovine) Monoclonal PLP1 Primary Antibody pour IHC (fro), FACS - ABIN2475779 : Ballard: Retrospective studies of left atrial thrombus: does misclassification impair their clinical utility? dans Journal of general internal medicine 1991 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal PLP1 Primary Antibody pour ICC, IF - ABIN151155 : Cachón-González, Wang, Ziegler, Cheng, Cox: Reversibility of neuropathology in Tay-Sachs-related diseases. dans Human molecular genetics 2014 (PubMed)

  4. Human Polyclonal PLP1 Primary Antibody pour IHC, IHC (p) - ABIN4337000 : Li, Tsuneki, Krauthammer, Couture, Schwartz, Madri: Modulation of Sox10, HIF-1?, Survivin, and YAP by Minocycline in the Treatment of Neurodevelopmental Handicaps following Hypoxic Insult. dans The American journal of pathology 2015 (PubMed)

Plus d’anticorps contre Proteolipid Protein 1 partenaires d’interaction

Human Proteolipid Protein 1 (PLP1) interaction partners

  1. These findings support the assumption that genetic variation in PLP1 affects white matter myelination in the healthy human brain.

  2. demonstrate for the first time that the wmN1 enhancer region: (1) is functional in hPLP1

  3. PLP1 mutation is associated with hereditary spastic paraplegia.

  4. Findings suggest that PLP1 and CNTN1 gene variations modulate specific aspects of callosal microstructure that are in line with their gene function.

  5. three single nucleotide polymorphisms in PLP1 that were associated with interhemispheric integration via the corpus callosum in a previous study also are relevant for functional hemispheric asymmetries.

  6. This study demonstrated that the plp and alpha-synuclein transgenic mouse model of multiple system atrophy showed the Progressive striatonigral degeneration.

  7. Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder caused by mutations in the PLP1 gene, which encodes the proteolipid protein of myelinating oligodendroglia.

  8. Proteolipid protein 1 and contactin 1 gene variation modulates interhemispheric integration

  9. Using whole exome sequencing, a novel pathogenic PLP1 missense mutation c.251C > A (p.Ala84Asp) was detected in a Moroccan family, allowing a diagnosis of Pelizaeus-Merzbacher Disease.

  10. down-regulated in cord blood by prenatal smoking

  11. Authors investigated the disease progression in mouse models carrying PLP1 point mutations previously found in patients displaying clinical features of multiple sclerosis. These mouse models show loss-of-function of PLP1 associated with neuroinflammation.

  12. Review focusing on sequences in hPLP1 intron 1 DNA deemed important for hPLP1 gene activity as well as a couple of "human-specific" supplementary exons within the first intron which are utilized to generate novel splice variants, and the potential role that these sequences may play in PLP1-linked disorders.

  13. it seems that the epitopes of some microorganisms mimicking PLP such as PLP58-74 might have a potential role in the initiation of Multiple Sclerosis.

  14. Human induced pluripotent stem cells-derived oligodendrocytes from 12 individuals with Pelizaeus-Merzbacher and identified individual and shared defects in PLP1 mRNA expression and splicing, oligodendrocyte progenitor development, and oligodendrocyte morphology and capacity for myelination.

  15. report a novel mutation of the PLP1 gene in two siblings with Pelizaeus-Merzbacher disease associated with a rare and protean neuroimaging finding of optic nerve enlargement

  16. Identification and functional study of novel PLP1 mutations in Chinese patients with Pelizaeus-Merzbacher disease. We identified PLP1 mutations in seven male patients with PMD.

  17. In major depressive disorder there was a significantly reduced expression of PLP1 mRNA.

  18. Study investigated 17 unrelated Pelizaeus-Merzbacher disease subjects with copy number gains at the PLP1 locus including triplication and quadruplication of specific genomic intervals-16/17 were found to have a duplication-inverted triplication-duplication rearrangement product.

  19. Myelin proteolipid protein is critical to regulating oligodendrocyte progenitor cell migration.

  20. PLP1 splicing mutations may result in a wide variety of disease phenotypes through a combination of multiple molecular pathogenic mechanisms.

Mouse (Murine) Proteolipid Protein 1 (PLP1) interaction partners

  1. Young adult Plp1-null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption.

  2. This report the mouse model in which maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons.

  3. These results suggest that colitis promotes rapid enteric neurogenesis in adult mice and humans through differentiation of Sox2- and PLP1-expressing cells, which represent enteric glia and/or neural progenitors

  4. This study demonstrated that Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.

  5. The rumpshaker missense mutation in the Plp1 gene gives rise to subcortical myoclonus

  6. axonal mitochondria, smooth endoplasmic reticulum, and microtubules were characterized in rodent optic nerves where PLP is replaced by the peripheral nerve myelin protein, P0.

  7. The observations collectively support the idea that GST-pi(Nuc)/DM-20 mRNA-expressing cells are the progeny of NG2-positive OPCs rather than a novel type of oligodendrocyte-lineage progenitor cells and that DM-20 mRNA expression is dynamically regulated during differentiation of OPCs into oligodendrocytes.

  8. In the absence of P0, thus, PLP also contributes to myelination by Schwann cells and to the preservation of peripheral axons

  9. while PLP can co-exist with P0 in peripheral nervous system(PNS) myelin, PLP cannot replace P0 as the major structural protein of PNS myelin.

  10. Both extracellular and intracellular epitopes of PLP contribute to the pathogenesis of MP4-induced experimental autoimmune encephalomyelitis already in the setting of intact myelin.

  11. The insertion of native PLP into Olg mitochondria of animals with PLP1/Plp1 regulates extracellular pH and adenosine triphosphate.

  12. This study shows for the first time that Plp-null mice exhibit severe early-onset thermal hyperalgesia that is not associated with changes in thermal allodynic behavior.

  13. A novel mechanism sheds light on the immune regulation by which sulfatide-reactive type II natural killer (NK)T cells suppress inflammatory class II histocompatibility-restricted pathogenic CD4+ T cell responses in a T cell-mediated autoimmune disease.

  14. that an early reactive glia response occurs following mutations in the PLP gene

  15. Result suggest that plp1 plays a role either in the structural integrity of oligodendrocyte progenitor cell processes or in their response to extracellular cues that orient process outgrowth.

  16. PLP significantly suppresses both models of experimental autoimmune encephalitis (EAE)even when there is some evidence of epitope spreading in the myelin oligodendrocyte (MOG)38-50-induced EAE model.

  17. PLP contributes to the high cholesterol content of myelin by association and co-transport in the central nervous system.

  18. Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum.

  19. PLP1 mutants inhibit Golgi apparatus to endoplasmic reticulum trafficking and have a role in pathogenesis of Pelizaeus-Merzbacher disease

  20. The results presented here suggest that the antisilencer/enhancer is largely dispensable for the developmental regulation of Plp1 gene expression in vivo.

Proteolipid Protein 1 (PLP1) profil antigène

Profil protéine

This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.

Gene names and symbols associated with PLP1

  • proteolipid protein 1 (PLP1) anticorps
  • proteolipid protein 1 (Plp1) anticorps
  • proteolipid protein 1 (plp1) anticorps
  • proteolipid protein (myelin) 1 (Plp1) anticorps
  • myelin proteolipid protein (Tsp_11640) anticorps
  • myelin proteolipid protein (plp) anticorps
  • proteolipid protein 1 L homeolog (plp1.L) anticorps
  • proteolipid protein 1a (plp1a) anticorps
  • DKFZp459O081 anticorps
  • DKFZp459O113 anticorps
  • DM20 anticorps
  • DMalpha2c anticorps
  • GPM6C anticorps
  • hld1 anticorps
  • jimpy anticorps
  • jp anticorps
  • mmpl anticorps
  • msd anticorps
  • plp anticorps
  • PLP/DM20 anticorps
  • plp1 anticorps
  • plp1a anticorps
  • pmd anticorps
  • rsh anticorps
  • spg2 anticorps
  • wu:fc27f01 anticorps
  • wu:fj36d03 anticorps
  • wu:fj42d08 anticorps
  • zgc:110499 anticorps

Protein level used designations for PLP1

lipophilin , major myelin proteolipid protein , myelin proteolipid protein , Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated) , Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) , proteolipid protein (myelin) 1 , proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) , proteolipid protein, lipophilin , proteolipid protein 1 , myelin synthesis deficiency , rump shaker , PLP , PLP-A , lipophilin-A , myelin proteolipid protein (PLP) , myelin proteolipid protein A , proteolipid protein 1 a , DMalpha1 , etID60288.14

GENE ID SPECIES
5354 Homo sapiens
24943 Rattus norvegicus
281410 Bos taurus
397029 Sus scrofa
465785 Pan troglodytes
481002 Canis lupus familiaris
613099 Xenopus (Silurana) tropicalis
100009169 Oryctolagus cuniculus
100173486 Pongo abelii
100174736 Pongo abelii
18823 Mus musculus
396214 Gallus gallus
10903177 Trichinella spiralis
100136749 Oncorhynchus mykiss
398334 Xenopus laevis
100220245 Taeniopygia guttata
64264 Danio rerio
100714212 Cavia porcellus
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