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PIM2 encodes a protooncogene that acts as a serine/threonine protein kinase. De plus, nous expédions Proto-Oncogene Pim-2 (Serine Threonine Kinase) Anticorps (130) et Proto-Oncogene Pim-2 (Serine Threonine Kinase) Kits (14) et beaucoup plus de produits pour cette protéine.
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Inhibition of the Pim1 (Montrer PIM1 Protéines) oncogene (Montrer RAB1A Protéines) results in diminished visual function.
Inhibition of PIM2 attenuated asthma symptoms and increased expression levels of interleukin (IL)10 (Montrer IL10 Protéines) and forkhead box protein 3 (Montrer HSPB3 Protéines) (FOXP3 (Montrer FOXP3 Protéines)) in bronchoalveolar lavage fluid.
data suggest that PIM1 (Montrer PIM1 Protéines)/2 kinase overexpression is a common feature of male reproductive organs tumors, which provoke tissue alterations and a large inflammatory response that may act synergistically during the process of tumorigenesis.
show that PIM1 (Montrer PIM1 Protéines) contributes to melanoma cell proliferation and tumor growth in vivo; however, the presence of PIM2 and PIM3 (Montrer PIM3 Protéines) could also influence the outcome.
the elevated expression of PIM2 in blastic cells is associated with poor prognosis of AML (Montrer RUNX1 Protéines) patients and their resistance to induction therapy.
Our data provide evidence for a novel role for Pim2 in the regulation of the DNA damage response (DDR (Montrer DDR1 Protéines)). Knockdown of Pim2 upregulates several downstream DDR (Montrer DDR1 Protéines) markers, mimicking the effects of doxorubicin (Dox) treatment of MM cells, and suggesting a role for the kinase as a negative regulator of this pathway.
These results demonstrate the involvement of PIM (Montrer PIM1 Protéines) kinases in LIF (Montrer LIF Protéines)-induced regulation in different trophoblastic cell lines which may indicate similar functions in primary cells.
PIM (Montrer PIM1 Protéines) kinases in classical Hodgkin lymphoma exhibit pleiotropic effects, orchestrating tumor immune escape and supporting Reed-Sternberg cell survival.
High PIM2 expression is associated with osteosarcoma.
We show that Pim2 inhibitors and proteasome inhibitors, such as bortezomib, have additive effects to inhibit the growth of myeloma cells, suggesting that Pim2 could be an interesting target for the treatment of multiple myeloma.
PIM2 gene knockdown enhances the anti-proliferative effect of AZD1208 in non-Hodgkin lymphoma cell line.
studies define a pathway for limiting the regulation of Foxp3 (Montrer FOXP3 Protéines) function because the Pim-2 kinase represents a potential therapeutic target for modulating the Treg cell suppressive activities in controlling immune responses
Pim2 facilitated allograft rejection primarily by modulating the apoptosis of effector T cells and the function of regulatory T cells.
Loss of PIM2 is associated with abnormal hematopoietic phenotypes.
signals from IL-7 (Montrer IL7 Protéines) and RAG DSBs activate distinct Pim (Montrer PIM1 Protéines) kinase family members that have context-dependent activities in regulating pre-B cell proliferation and survival.
Targeting cap-dependent translation blocks converging survival signals by AKT (Montrer AKT1 Protéines) and PIM 1 (Montrer PIM1 Protéines), 2 kinases in lymphoma
PIM2 controls the expression of the pro-inflammatory cytokine IL-6 (Montrer IL6 Protéines).
results support the hypothesis that Pim2, which is also a known target of Flt3 (Montrer FLT3 Protéines)-ITD (another gene that cooperates with PML (Montrer PML Protéines)-RARalpha (Montrer RARA Protéines)), cooperates with PRalpha to induce acute promyelocytic leukemia (Montrer PML Protéines)-like disease
Pim-2 is a direct link between growth factor-induced transcription and a novel, kinase-dependent pathway that promotes cell-autonomous survival
pim-2 functions similarly to pim-1 (Montrer PIM1 Protéines) as a pro-survival kinase; BAD is a legitimate PIM-2 substrate
Pim-2 and Akt-1 (Montrer AKT1 Protéines) are critical components of overlapping but independent pathways, either of which is sufficient to promote the growth and survival of nontransformed hematopoietic cells
This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.
, proviral integration site 2
, serine/threonine-protein kinase Pim-1
, serine/threonine-protein kinase pim-2
, proto-oncogene Pim-2 (serine threonine kinase)
, serine/threonine protein kinase pim-2
, serine/threonine kinase