Pterin-4 alpha-Carbinolamine Dehydratase/dimerization Cofactor of Hepatocyte Nuclear Factor 1 alpha Protéines (PCBD1)

PCBD1 encodes pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation. De plus, nous expédions PCBD1 Anticorps (52) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PCBD1 13180 P61458
PCBD1 5092 P61457
PCBD1 29700 P61459
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Top PCBD1 Protéines sur anticorps-enligne.fr

Showing 10 out of 16 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Escherichia coli (E. coli) Humain His tag   50 μg Connectez-vous pour afficher 4 Days
$522.50
Détails
Escherichia coli (E. coli) Humain His tag Validation with Western Blot 10 μg Connectez-vous pour afficher 8 to 11 Days
$504.90
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$547.80
Détails
Levure Humain His tag 100 μg Connectez-vous pour afficher 8 to 11 Days
$484.00
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 15 to 19 Days
$400.00
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,185.33
Détails
Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,185.33
Détails

PCBD1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human , , ,
, ,
Rat (Rattus)

Plus protéines pour Pterin-4 alpha-Carbinolamine Dehydratase/dimerization Cofactor of Hepatocyte Nuclear Factor 1 alpha (PCBD1) partenaires d'interaction

Mouse (Murine) Pterin-4 alpha-Carbinolamine Dehydratase/dimerization Cofactor of Hepatocyte Nuclear Factor 1 alpha (PCBD1) interaction partners

  1. DCoH acts as a cofactor for HNF1 that stabilizes the dimeric HNF1 complex.

  2. HNF1alpha (Montrer HNF1A Protéines) binding kinetics may distinguish regulation by DCoH2 (Montrer PCBD2 Protéines), under thermodynamic control, from regulation by DCoH, under kinetic control

Human Pterin-4 alpha-Carbinolamine Dehydratase/dimerization Cofactor of Hepatocyte Nuclear Factor 1 alpha (PCBD1) interaction partners

  1. We provide the first genetic evidence that PCBD1 mutations can cause early-onset nonautoimmune diabetes with features similar to dominantly inherited HNF1A (Montrer HNF1A Protéines)-diabetes.

  2. Coactivator of the HNFB1 (HNF1 homeobox B (Montrer HNF1B Protéines))-mediated transcription is necessary for fine tuning ATPase Na+/K+ transporting gamma 1 polypeptide (FXYD2 (Montrer FXYD2 Protéines)) transcription in the distal convoluted tubule

  3. Pcbd1 is a moonlighting protein that has dehydratase activity in addition to functioning as a cofactor which regulates HNF1alpha (Montrer HNF1A Protéines).

  4. variants of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2 (Montrer HNF1B Protéines)) and the dimerization cofactor of HNF-1 (DcoH/PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function

  5. Data reveal DCoH/HNF-1 alpha (Montrer HNF1A Protéines) expression and transcriptional activity in human epidermal melanocytes in vitro and in situ and identified tyrosinase (Montrer TYR Protéines), the key enzyme for pigmentation, as a new transcriptional target.

  6. Albumin (Montrer ALB Protéines) colocalized together with its transcription factor PCD/DCoH/HNF-1alpha (Montrer HNF1A Protéines) in suprabasal keratinocytes in human full-thickness skin sections and in keratinocytes cultured in serum-free medium.

  7. Properties of dehydratase/DCoHalpha are consistent with hypothesis that activity of this isozyme could account for relatively mild symptoms reported for patients with a defect in dehydratase/DCoH

Profil protéine PCBD1

Profil protéine

This gene encodes pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation. A deficiency of this enzyme leads to hyperphenylalaninemia. The enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1).

Gene names and symbols associated with PCBD1

  • pterin-4a-carbinolamine dehydratase (Pcd)
  • pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (pcbd1)
  • pterin-4-alpha-carbinolamine dehydratase (Tb11.02.4890)
  • pterin-4-alpha-carbinolamine dehydratase (pcbd)
  • pterin-4-alpha-carbinolamine dehydratase (Fbal_2579)
  • pterin-4-alpha-carbinolamine dehydratase (Ftrac_2004)
  • pterin-4-alpha-carbinolamine dehydratase (Celal_2911)
  • pterin-4-alpha-carbinolamine dehydratase (Isop_1133)
  • pterin-4-alpha-carbinolamine dehydratase (Celly_0291)
  • pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 (Pcbd1)
  • pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha L homeolog (pcbd1.L)
  • pterin-4 alpha-carbinolamine dehydratase 1 (PCBD1)
  • pterin-4 alpha-carbinolamine dehydratase 1 (Pcbd1)
  • BcDNA:LP07248 Protéine
  • CG1963 Protéine
  • DCoH Protéine
  • DDBDRAFT_0204977 Protéine
  • DDBDRAFT_0305045 Protéine
  • DDB_0204977 Protéine
  • DDB_0305045 Protéine
  • Dmel\\CG1963 Protéine
  • PCBD Protéine
  • pcd Protéine
  • PHS Protéine
  • TCF1 Protéine
  • Xdcoh Protéine
  • zgc:73389 Protéine

Protein level used designations for PCBD1

CG1963-PA , Pcd-PA , pterin-4-alpha-carbinolamine dehydratase , 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) , 4-alpha-hydroxy-tetrahydropterin dehydratase , PCD , PHS , dimerization cofactor of HNF1 , dimerization cofactor of hepatocyte nuclear factor 1-alpha , dimerization cofactor of hepatocyte nuclear factor-1-alpha , phenylalanine hydroxylase-stimulating protein , pterin carbinolamine dehydratase , DCoH , XDCoH , 6-pyruvoyl-tetrahydropterin synthase , cDcoH , pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) , dimerizing cofactor for HNF1 , pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1

GENE ID SPECIES
43499 Drosophila melanogaster
393787 Danio rerio
496425 Xenopus (Silurana) tropicalis
3665797 Trypanosoma brucei brucei strain 927/4 GUTat10.1
8623790 Dictyostelium discoideum AX4
9771410 Ferrimonas balearica DSM 9799
10012150 Marivirga tractuosa DSM 4126
10145334 Cellulophaga algicola DSM 14237
10155246 Isosphaera pallida ATCC 43644
10262275 Cellulophaga lytica DSM 7489
13180 Mus musculus
397951 Xenopus laevis
395729 Gallus gallus
5092 Homo sapiens
530736 Bos taurus
29700 Rattus norvegicus
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