anti-Pumilio Homolog 1 (Drosophila) (PUM1) Anticorps

PUM1 encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. De plus, nous expédions Pumilio Homolog 1 (Drosophila) Protéines (3) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PUM1 80912 Q80U78
PUM1 362609  
PUM1 9698 Q14671
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Top anti-Pumilio Homolog 1 (Drosophila) Anticorps sur anticorps-enligne.fr

Showing 10 out of 77 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué EIA, IHC (p) 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB Formalin-fixed and paraffin-embedded humanbrain tissue reacted with Phospho-PUM1-Y83.ctrl antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of PUM1 (arrow) using PUM1 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PUM1 gene (Lane 2) 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human testis tissue reacted with PUM1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of PUM1 (arrow) using rabbit polyclonal PUM1 Antibody 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of PUM1 using HuvEc whole  lysates. 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué IHC, WB Immunohistochemical analysis of Pumilio 1 staining in mouse brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with t Western blot analysis of Pumilio 1 expression in K562 (A), NIH3T3 (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-Pumilio 1 Polyclonal Antibody, Unconjugated (ABIN1387238) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
$317.90
Détails
Humain Lapin Inconjugué IHC (p), WB Western Blot at 1:1000 dilution + NCCIT whole cell lysate Lysates/proteins at 20 ug per lane. Western blot analysis of PUM1 using PUM1 Antibody (Y83) using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PUM1 gene (Lane 2). 400 μL 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué WB Western blot analysis of extracts of various cell lines, using PUM1 antibody. Immunohistochemistry of paraffin-embedded mouse brain using PUM1 antibody at dilution of 1:100 (40x lens). 100 μL 11 to 13 Days
$366.77
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of various cell lines, using PUM1 antibody. Immunohistochemistry of paraffin-embedded mouse brain using PUM1 antibody. 200 μL 12 to 14 Days
$438.90
Détails
Humain Lapin Inconjugué IHC, WB 100 μL 11 to 18 Days
$383.76
Détails

anti-Pumilio Homolog 1 (Drosophila) Anticorps mieux référencés

  1. Human Polyclonal PUM1 Primary Antibody pour GS, IP - ABIN151726 : Chiu, Witkowska, Hall, Santiago, Soros, Esnault, Heidmann, Greene: High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition. dans Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 5 Pubmed References

Plus d’anticorps contre Pumilio Homolog 1 (Drosophila) partenaires d’interaction

Zebrafish Pumilio Homolog 1 (Drosophila) (PUM1) interaction partners

  1. Pum1 phosphorylation in the early period of oocyte maturation is one of the key processes for promoting the disassembly of cyclin B1 RNA granules and translational activation of target mRNA.

Mouse (Murine) Pumilio Homolog 1 (Drosophila) (PUM1) interaction partners

  1. major role of Pum1 and Pum2 in hippocampal neurogenesis and function

  2. important role in the establishment of the primordial follicle pool, meiosis, and female reproductive competency

  3. Data indicate a role for RNA-binding protein Pum1 in early embryonic development.

  4. The RNA-binding protein PUMILIO1 (PUM1) not only directly regulates ATAXIN1 but also plays an unexpectedly important role in neuronal function. Loss of Pum1 caused progressive motor dysfunction and SCA1-like neurodegeneration with motor impairment, primarily by increasing Ataxin1 levels.

  5. Key components of the p53 pathway are coordinately regulated by Pumilio 1 at the posttranscriptional level, which may exemplify an RNA operon.

  6. In mice, puf-A expression was detected primarily in retinal ganglion and pigmented cells.

Human Pumilio Homolog 1 (Drosophila) (PUM1) interaction partners

  1. A transcriptome-wide approach was used to determine the binding profiles and inter-dependencies of Argonaute2 (AGO2), Pumilio (PUM1 and PUM2) sites on mRNA 3' untranslated regions (3'UTRs).

  2. We have used the RNA-MaP platform to directly measure equilibrium binding for thousands of designed RNAs and to construct a predictive model for RNA recognition by the human Pumilio proteins PUM1 and PUM2.

  3. the extent of Pumilio binding to the endogenous RGC-32 mRNA in EBV-infected cell lines also correlated with RGC-32 protein expression. Our data demonstrate the importance of RGC-32 for the survival of EBV-immortalised B cells and identify Pumilio as a key regulator of RGC-32 translation.

  4. Data indicate that RNAs-including mRNAs and non-coding RNAs-that are functionally regulated by Pumilio proteins, PUM1 and PUM2.

  5. Using the novel PUM1 and PUM2 mRNA target SIAH1 as a model, this study shows mechanistic differences between PUM1 and PUM2 and between NANOS1, 2, and 3 paralogues in the regulation of SIAH1.

  6. Studies in patient-derived cells revealed that the missense mutations reduced PUM1 protein levels by approximately 25% in the adult-onset cases and by approximately 50% in the infantile-onset cases; levels of known PUM1 targets increased accordingly.

  7. Variants in PUM1 may not contribute to primary ovarian insufficiency in Han Chinese women

  8. PUM1 SNP is associated with Osteoporosis and Obesity.

  9. Results indicate that pumilio RNA binding family member 1 (PUM1) is a negative regulator of RNA helicase LGP2 (LGP2), a master regulator of innate immunity genes expressed in a cascade fashion.

  10. Thus, PUM1 promotes the development and progression of ovarian cancer, which may occur via the above-mentioned molecules.

  11. A recent paper by the Mendell group identifies NORAD, a novel lncRNA that is regulated in response to DNA damage and plays a key role in maintaining genome integrity by modulating the activity the RNA binding proteins PUM2 and PUM1.

  12. results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1/2 and FOXP1 in regulating normal hematopoietic stem/progenitor cell and leukemic cell growth.

  13. Pumilios (including PUM1 and PUM2) are RNA-binding proteins with Puf domains made up of 8 poorly conserved Puf repeats, 3 helix bundles arranged in rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence. [REVIEW]

  14. Identification of NORAD-interacting proteins revealed that this lncRNA functions as a multivalent binding platform for PUM proteins, with the capacity to sequester a significant fraction of the total cellular pool of PUM1 and PUM2.Studies reveal unanticipated roles for a lncRNA and PUMILIO proteins in the maintenance of genomic stability.

  15. PUM repeats have now been identified in proteins that function in pre-rRNA processing, including human Puf-A and yeast Puf6.

  16. The promoting effect of hPuf-A in tumorigenesis might be correlated with the regulation of its associated mRNAs.

  17. MED15 and PUM1 proteins with coiled-coil domains are potent enhancers of polyQ-mediated ataxin-1 protein misfolding and proteotoxicity in vitro and in vivo.

  18. human Pumilio homologs Pum 1 and Pum 2 repress the translation of E2F3 by binding to the E2F3 3' untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs (miRNAs)

  19. Three distinct modes of target RNA binding by PUM1 around the fifth mRNA base were observed.

  20. Pumilio-1 (PUM1) is a ubiquitously expressed RBP that was shown to interact with p27-3' UTR.

Pumilio Homolog 1 (Drosophila) (PUM1) profil antigène

Profil protéine

This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with PUM1

  • pumilio RNA-binding family member 1 (pum1) anticorps
  • pumilio RNA binding family member 1 (PUM1) anticorps
  • pumilio RNA binding family member 1 (pum1) anticorps
  • pumilio RNA-binding family member 1 (Pum1) anticorps
  • AA517475 anticorps
  • DKFZp459K0627 anticorps
  • fb96a03 anticorps
  • HSPUM anticorps
  • mKIAA0099 anticorps
  • PUM1 anticorps
  • PUMH anticorps
  • PUMH1 anticorps
  • pumilio1 anticorps
  • PUML1 anticorps
  • Pumm anticorps
  • si:ch211-285e16.1 anticorps
  • wu:fb96a03 anticorps
  • wu:fb96a08 anticorps
  • zgc:63671 anticorps

Protein level used designations for PUM1

pumilio homolog 1 , pumilio homolog 1 (Drosophila) , pumilio-1 , pumilio 1

GENE ID SPECIES
394176 Danio rerio
100174674 Pongo abelii
100135847 Oncorhynchus mykiss
80912 Mus musculus
419554 Gallus gallus
362609 Rattus norvegicus
9698 Homo sapiens
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