Pumilio Homolog 1 (Drosophila) Protéines (PUM1)

PUM1 encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. De plus, nous expédions Pumilio Homolog 1 (Drosophila) Anticorps (65) et beaucoup plus de produits pour cette protéine.

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PUM1 80912 Q80U78
Rat PUM1 PUM1 362609  
PUM1 9698 Q14671
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
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Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
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PUM1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human ,
,

Plus protéines pour Pumilio Homolog 1 (Drosophila) (PUM1) partenaires d'interaction

Zebrafish Pumilio Homolog 1 (Drosophila) (PUM1) interaction partners

  1. Pum1 phosphorylation in the early period of oocyte maturation is one of the key processes for promoting the disassembly of cyclin B1 RNA granules and translational activation of target mRNA.

Mouse (Murine) Pumilio Homolog 1 (Drosophila) (PUM1) interaction partners

  1. major role of Pum1 and Pum2 in hippocampal neurogenesis and function

  2. important role in the establishment of the primordial follicle pool, meiosis, and female reproductive competency

  3. Data indicate a role for RNA-binding protein Pum1 in early embryonic development.

  4. The RNA-binding protein PUMILIO1 (PUM1) not only directly regulates ATAXIN1 but also plays an unexpectedly important role in neuronal function. Loss of Pum1 caused progressive motor dysfunction and SCA1-like neurodegeneration with motor impairment, primarily by increasing Ataxin1 levels.

  5. Key components of the p53 pathway are coordinately regulated by Pumilio 1 at the posttranscriptional level, which may exemplify an RNA operon.

  6. In mice, puf-A expression was detected primarily in retinal ganglion and pigmented cells.

Human Pumilio Homolog 1 (Drosophila) (PUM1) interaction partners

  1. Using the novel PUM1 and PUM2 mRNA target SIAH1 as a model, this study shows mechanistic differences between PUM1 and PUM2 and between NANOS1, 2, and 3 paralogues in the regulation of SIAH1.

  2. Studies in patient-derived cells revealed that the missense mutations reduced PUM1 protein levels by approximately 25% in the adult-onset cases and by approximately 50% in the infantile-onset cases; levels of known PUM1 targets increased accordingly.

  3. Variants in PUM1 may not contribute to primary ovarian insufficiency in Han Chinese women

  4. PUM1 SNP is associated with Osteoporosis and Obesity.

  5. Results indicate that pumilio RNA binding family member 1 (PUM1) is a negative regulator of RNA helicase LGP2 (LGP2), a master regulator of innate immunity genes expressed in a cascade fashion.

  6. Thus, PUM1 promotes the development and progression of ovarian cancer, which may occur via the above-mentioned molecules.

  7. A recent paper by the Mendell group identifies NORAD, a novel lncRNA that is regulated in response to DNA damage and plays a key role in maintaining genome integrity by modulating the activity the RNA binding proteins PUM2 and PUM1.

  8. results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1/2 and FOXP1 in regulating normal hematopoietic stem/progenitor cell and leukemic cell growth.

  9. Pumilios (including PUM1 and PUM2) are RNA-binding proteins with Puf domains made up of 8 poorly conserved Puf repeats, 3 helix bundles arranged in rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence. [REVIEW]

  10. Identification of NORAD-interacting proteins revealed that this lncRNA functions as a multivalent binding platform for PUM proteins, with the capacity to sequester a significant fraction of the total cellular pool of PUM1 and PUM2.Studies reveal unanticipated roles for a lncRNA and PUMILIO proteins in the maintenance of genomic stability.

  11. PUM repeats have now been identified in proteins that function in pre-rRNA processing, including human Puf-A and yeast Puf6.

  12. The promoting effect of hPuf-A in tumorigenesis might be correlated with the regulation of its associated mRNAs.

  13. MED15 and PUM1 proteins with coiled-coil domains are potent enhancers of polyQ-mediated ataxin-1 protein misfolding and proteotoxicity in vitro and in vivo.

  14. human Pumilio homologs Pum 1 and Pum 2 repress the translation of E2F3 by binding to the E2F3 3' untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs (miRNAs)

  15. Three distinct modes of target RNA binding by PUM1 around the fifth mRNA base were observed.

  16. Pumilio-1 (PUM1) is a ubiquitously expressed RBP that was shown to interact with p27-3' UTR.

  17. The reference genes of choice when performing RT-qPCR on normal and malignant breast specimens should be either the collected group of 3 genes (TBP, RPLP0 and PUM1) employed as an average, or PUM1 as a single gene.

  18. Description of the structures of hPum Puf domain complexed to two noncognate RNAs, CycB(reverse) and Puf5.

  19. ribonomic analysis of mRNAs associated with ribonucleoproteins containing an endogenous human PUF protein, Pum1

  20. Puf-A transcripts were uniformly distributed in early embryos, but became restricted primarily to eyes and ovaries at a later stage of development

Profil protéine Pumilio Homolog 1 (Drosophila) (PUM1)

Profil protéine

This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with PUM1

  • pumilio RNA-binding family member 1 (pum1)
  • pumilio RNA binding family member 1 (PUM1)
  • pumilio RNA binding family member 1 (pum1)
  • pumilio RNA-binding family member 1 (Pum1)
  • AA517475 Protéine
  • DKFZp459K0627 Protéine
  • fb96a03 Protéine
  • HSPUM Protéine
  • mKIAA0099 Protéine
  • PUM1 Protéine
  • PUMH Protéine
  • PUMH1 Protéine
  • pumilio1 Protéine
  • PUML1 Protéine
  • Pumm Protéine
  • si:ch211-285e16.1 Protéine
  • wu:fb96a03 Protéine
  • wu:fb96a08 Protéine
  • zgc:63671 Protéine

Protein level used designations for PUM1

pumilio homolog 1 , pumilio homolog 1 (Drosophila) , pumilio-1 , pumilio 1

GENE ID SPECIES
394176 Danio rerio
100174674 Pongo abelii
100135847 Oncorhynchus mykiss
80912 Mus musculus
419554 Gallus gallus
362609 Rattus norvegicus
9698 Homo sapiens
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