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PUM1 encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. De plus, nous expédions Pumilio Homolog 1 (Drosophila) Anticorps (61) et beaucoup plus de produits pour cette protéine.
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Data indicate a role for RNA-binding protein Pum1 in early embryonic development.
The RNA-binding protein PUMILIO1 (PUM1) not only directly regulates ATAXIN1 (Montrer ATXN1 Protéines) but also plays an unexpectedly important role in neuronal function. Loss of Pum1 caused progressive motor dysfunction and SCA1 (Montrer ATXN1 Protéines)-like neurodegeneration with motor impairment, primarily by increasing Ataxin1 (Montrer ATXN1 Protéines) levels.
Key components of the p53 (Montrer TP53 Protéines) pathway are coordinately regulated by Pumilio 1 at the posttranscriptional level, which may exemplify an RNA operon.
In (Montrer NME1 Protéines)mice, puf-A expression was detected primarily in retinal ganglion and pigmented cells.
PUM1 SNP is associated with Osteoporosis and Obesity.
Results indicate that pumilio RNA binding family member 1 (PUM1) is a negative regulator of RNA helicase LGP2 (LGP2 (Montrer DHX58 Protéines)), a master regulator of innate immunity genes expressed in a cascade fashion.
Thus, PUM1 promotes the development and progression of ovarian cancer, which may occur via the above-mentioned molecules.
A recent paper by the Mendell group identifies NORAD, a novel lncRNA that is regulated in response to DNA damage and plays a key role in maintaining genome integrity by modulating the activity the RNA binding proteins PUM2 (Montrer PUM2 Protéines) and PUM1.
results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1/2 and FOXP1 (Montrer FOXP1 Protéines) in regulating normal hematopoietic stem/progenitor cell and leukemic cell growth.
Pumilios (including PUM1 and PUM2 (Montrer PUM2 Protéines)) are RNA-binding proteins with Puf domains made up of 8 poorly conserved Puf repeats, 3 helix bundles arranged in rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence. [REVIEW]
Identification of NORAD-interacting proteins revealed that this lncRNA functions as a multivalent binding platform for PUM (Montrer MYOD1 Protéines) proteins, with the capacity to sequester a significant fraction of the total cellular pool of PUM1 and PUM2 (Montrer PUM2 Protéines).Studies reveal unanticipated roles for a lncRNA and PUMILIO proteins in the maintenance of genomic stability.
PUM repeats have now been identified in proteins that function in pre-rRNA processing, including human Puf-A and yeast Puf6.
The promoting effect of hPuf-A in tumorigenesis might be correlated with the regulation of its associated mRNAs.
MED15 (Montrer MED15 Protéines) and PUM1 proteins with coiled-coil domains are potent enhancers of polyQ-mediated ataxin-1 (Montrer ATXN1 Protéines) protein misfolding and proteotoxicity in vitro and in vivo.
This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.
pumilio homolog 1
, pumilio homolog 1 (Drosophila)
, pumilio 1