Pyruvate Dehydrogenase (Lipoamide) alpha 1 Protéines (PDHA1)

PDHA1 encodes a subunit of mitochondrial ATP synthase. De plus, nous expédions PDHA1 Anticorps (174) et PDHA1 Kits (19) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PDHA1 5160 P08559
PDHA1 18597 P35486
PDHA1 29554  
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Showing 10 out of 17 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Détails
Baculovirus infected Insect Cells Humain GST tag,His tag 100 μg 14 to 16 Days
$505.35
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
Détails
Levure Sanglier His tag   1 mg 60 to 71 Days
$2,986.50
Détails
Levure Rat His tag   1 mg 60 to 71 Days
$2,986.50
Détails
Levure Boeuf (Vache) His tag   1 mg 60 to 71 Days
$2,986.50
Détails
Levure Chimpanzé His tag   1 mg 60 to 71 Days
$2,986.50
Détails
Levure Cynomolgus His tag   1 mg 60 to 71 Days
$2,986.50
Détails

PDHA1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) partenaires d'interaction

Human Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. Both mitochondrial and nuclear Pyruvate dehydrogenase complex sustain prostate tumorigenesis by controlling lipid biosynthesis, thus suggesting this complex as a potential target for cancer therapy.

  2. our data indicate that reduced PDHA1 protein expression is associated with the poor clinical outcome of HCC. Upregulated PDHA1 gene expression can inhibit the Warburg effect and enhance the mitochondria-mediated apoptosis pathway.

  3. PDHA1 (P = 0.025) was an independent predictor of overall survival in gastric cancer

  4. PDHc E1 mutation i9s associated with Pyruvate dehydrogenase complex deficiency.

  5. Case demonstrates fetal akinesia deformation sequence due to a de novo hemizygous c.498C > T splice-site mutation in the pyruvate dehydrogenase-alpha 1 (PDHA1) gene.

  6. Data show that metformin reduces hypoxia-inducible factor 1alpha (HIF-1alpha) gene expression and increases pyruvate dehydrogenase (PDH) expression.

  7. The report PDHA1 as a new component of brainstem-type Lewy bodies in idiopathic PD, DLB and PARK14, the level of PDHA1 protein being significantly decreased in the putamen and substantia nigra of patients with idiopathic Parkinson's disease .

  8. Findings show that serine-threonine-tyrosine kinase 1 (NOK) mediates glycolysis and nuclear pyruvate dehydrogenase complex (PDC) associated histone acetylation.

  9. The association of mitochondrial microphthalmia-associated transcription factor (MITF) with pyruvate dehydrogenase (PDH) emerges as an important regulator of mast cell function. Our findings indicate that PDH could arise as a new target for the manipulation of allergic diseases.

  10. our results show that negative PDHA1 gene expressionis associated with significantly higher cell stemness in prostate cancer cells and reduced protein expression of this gene is associated with shorter clinical outcome in prostate cancers.

  11. oncoprotein HBXIP enhances glucose metabolism reprogramming through suppressing SCO2 and PDHA1 in breast cancer

  12. Lack of PDHE1alpha protein expression is associated with Esophageal Squamous Cell Carcinoma.

  13. MPO and BPI in CD4(+)T-lymphocytes, and PDHA1 and MRPL42 in CD8(+) T-lymphocytes might be used as specific biomarkers of severe asthma progression.

  14. Phosphorylation at distinct serine and tyrosine residues inhibits PDHA1 through distinct mechanisms to impact active site accessibility.

  15. High HK2 expression combined with low phosphorylated PDHA1 expression in the invasive front lesions of colorectal tumors is predictive of tumor aggressiveness and survival.

  16. In the presence of PPARbeta/delta, Vpr induced a 3.3-fold increase in PPAR response element-driven transcriptional activity, a 1.9-fold increase in PDK4 protein expression, and a 1.6-fold increase in the phosphorylated pyruvate dehydrogenase subunit E1alpha.

  17. In this study the phenotypes of patients with PDH deficiency have been divided into three groups of mutations.

  18. Expression of the PDHA1 gene was found in all somatic cells, whereas expression of PDHA2 gene was restricted to germ cells. The switch from X-linked to autosomic gene expression occurred in spermatocytes.

  19. Molecular analysis of PDH1A revealed a novel hemizygous c.1045G>A mutation, predicting a p.A349T missense mutation.

  20. Skin fibroblast culture assay revealed PDH deficiency, confirmed by mutation analysis of the E1 alpha subunit.

Mouse (Murine) Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. Both mitochondrial and nuclear Pyruvate dehydrogenase complex sustain prostate tumorigenesis by controlling lipid biosynthesis, thus suggesting this complex as a potential target for cancer therapy.

  2. The genetic deletion of the Grx2 gene was associated with increased protein expression of pyruvate dehydrogenase (PDH) but not 2-oxoglutarate dehydrogenase (OGDH).

  3. Cardiac PDH E1alpha deficiency impairs ischemic AMP-activated protein kinase signaling and sensitizes hearts to the toxicological actions of ischemic stress.

  4. Taken together, our results indicate that the redox sensing and ROS forming properties of Pdh and Ogdh are linked to S-glutathionylation

  5. Systemic Pyruvate Dehydrogenase Deficiency is associated with Cerebral Developmental Abnormalities.

  6. The association of mitochondrial microphthalmia-associated transcription factor (MITF) with pyruvate dehydrogenase (PDH) emerges as an important regulator of mast cell function. Our findings indicate that PDH could arise as a new target for the manipulation of allergic diseases.

  7. skeletal muscle IL-6 contributes to the regulation of PDH at rest and during prolonged exercise.

  8. The present findings suggest that IL-6 contributes to regulating the PDHa activity and hence carbohydrate oxidation, but the metabolic state of the muscle seems to determine the outcome of this regulation

  9. Liver-specific pyruvate dehydrogenase complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin sensitivity.

  10. PGC-1alpha regulates PDH-E1alpha protein content in parallel with mitochondrial oxidative proteins, but does not seem to influence PDH regulation in mouse skeletal muscle in response to fasting and in recovery from exercise.

  11. Embryos carrying predominantly the Pdha1(deletion in exon 8, Deltaex8) allele were found to be globally delayed in development by 9.5 days postcoitus, with resorption occurring over the following several days.

Zebrafish Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. The study provired that pyruvate dehydrogenase-deficient mutant caused the retinal drficits in zebrafish.

Profil protéine PDHA1

Profil protéine

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PDHA1

  • pyruvate dehydrogenase E1 alpha 1 subunit (PDHA1)
  • pyruvate dehydrogenase E1 alpha 1 (Pdha1)
  • pyruvate dehydrogenase E1 alpha 1 subunit (Pdha1)
  • pyruvate dehydrogenase (lipoamide) alpha 1 (PDHA1)
  • pyruvate dehydrogenase E1 alpha 1 subunit (pdha1)
  • pyruvate dehydrogenase (lipoamide) alpha 1 pseudogene (LOC719277)
  • 2-oxo acid dehydrogenase (VNG_RS07485)
  • pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha (RR_RS04695)
  • pyruvate dehydrogenase alpha subunit protein (pdhA1)
  • pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit (pdhA1)
  • precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit (PDHA1)
  • pyruvate dehydrogenase (PDHA1)
  • pyruvate dehydrogenase E1 alpha 1 subunit b (pdha1b)
  • pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog (pdha1.S)
  • pdha Protéine
  • Pdha-1 Protéine
  • Pdha1 Protéine
  • pdha1-a Protéine
  • pdha1-b Protéine
  • pdhce1a Protéine
  • phe1a Protéine
  • wu:fp73b04 Protéine
  • zgc:92705 Protéine

Protein level used designations for PDHA1

PDHE1-A type I , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , pyruvate dehydrogenase complex, E1-alpha polypeptide 1 , pyruvate dehydrogenase E1alpha subunit , pyruvate dehydrogenase E1 alpha 1 , pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase alpha 1 , pyruvate dehydrogenase (lipoamide) alpha 1 , PdhA1 , pyruvate dehydrogenase alpha subunit , pyruvate dehydrogenase E1 component subunit alpha , pyruvate dehydrogenase alpha subunit protein , pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit , precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase , Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like , fp73b04 , pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog

GENE ID SPECIES
5160 Homo sapiens
18597 Mus musculus
29554 Rattus norvegicus
407109 Bos taurus
418610 Gallus gallus
465525 Pan troglodytes
480858 Canis lupus familiaris
549826 Xenopus (Silurana) tropicalis
719277 Macaca mulatta
1448416 Halobacterium sp. NRC-1
3129238 Haloarcula marismortui ATCC 43049
3893971 Rhizobium etli CFN 42
6400117 Rhizobium etli CIAT 652
7195506 Phaeodactylum tricornutum CCAP 1055/1
7369176 Agrobacterium radiobacter K84
7450426 Thalassiosira pseudonana CCMP1335
100174745 Pongo abelii
100294678 Sus scrofa
100357349 Oryctolagus cuniculus
100400144 Callithrix jacchus
100471829 Ailuropoda melanoleuca
100587584 Nomascus leucogenys
436672 Danio rerio
100735725 Cavia porcellus
447434 Xenopus laevis
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