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QPRT encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. De plus, nous expédions QPRT Anticorps (73) et QPRT Kits (12) et beaucoup plus de produits pour cette protéine.
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WT1 (Montrer WT1 Protéines) knock-down gave a corresponding decrease in QPRT gene and protein expression. Chromatin-immunoprecipitation revealed WT1 (Montrer WT1 Protéines) binding to a conserved site in the first intron of the QPRT gene.
The structural features, size distribution, heat aggregation and ITC studies of the full-length enzyme and the enzyme lacking helix alpha1 strongly suggest that human QPRT acts as a hexamer for cooperative reactant binding via three dimeric subunits and maintaining stability.
Report of the crystal structure of human QPRT bound to its inhibitor phthalic acid (PHT) and kinetic analysis of PHT inhibition of human QPRT.
QPRT is a potential new marker for the immunohistochemical screening of follicular thyroid nodules.
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.
, nicotinate-nucleotide pyrophosphorylase (carboxylating)
, nicotinate-nucleotide pyrophosphorylase [carboxylating]
, nicotinate-nucleotide pyrophosphorylase
, quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating))