anti-R-Spondin 2 (RSPO2) Anticorps

R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1\\\\; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008].. De plus, nous expédions R-Spondin 2 Kits (12) et R-Spondin 2 Protéines (10) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
RSPO2 500863  
RSPO2 340419 Q6UXX9
RSPO2 239405 Q8BFU0
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Top anti-R-Spondin 2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 24 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué FACS, IHC (p), WB Western blot analysis of lysate from 293 cell line, using RSPO2 Antibody at 1:1000 at each lane. RSPO2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué ELISA, WB   100 μL 11 to 13 Days
$335.04
Détails
Humain Lapin HRP FACS, IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Détails
Humain Lapin Biotin FACS, IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Détails
Humain Lapin Alkaline Phosphatase (AP) FACS, IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Détails
Humain Lapin FITC FACS, IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Détails
Humain Lapin PE FACS, IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Détails
Humain Lapin Inconjugué FACS, IHC, IHC (p), WB   400 μL 11 to 14 Days
$493.17
Détails
Humain Lapin Inconjugué ELISA, FACS, IHC, WB   200 μL 11 to 14 Days
$881.83
Détails
Humain Lapin Inconjugué FACS, IHC, ELISA, WB   200 μL 11 to 16 Days
$658.43
Détails

anti-R-Spondin 2 Anticorps mieux référencés

  1. Human Polyclonal RSPO2 Primary Antibody pour IHC, IHC (p) - ABIN4348853 : Michelotti, Jiang, Sosa, Diehl, Henderson: LGR5 is associated with tumor aggressiveness in papillary thyroid cancer. dans Oncotarget 2015 (PubMed)

Plus d’anticorps contre R-Spondin 2 partenaires d’interaction

Human R-Spondin 2 (RSPO2) interaction partners

  1. RSPO2, but not SPON1, specifically promoted the differentiation of midbrain dopaminergic (mDA) neuroblasts into mDA neurons in mouse primary cultures and embryonic stem cells (ESCs).

  2. Study in different human cancer cell lines revealed that Rspo2 is C-mannosylated at Trp150 and Trp153, and these modifications alter its secretory levels and intracellular trafficking. In addition, C-mannosylation of Rspo2 regulated the agonistic activity of Rspo2 in the Wnt/beta-catenin signaling pathway and on cancer cell migration. These results suggested that Cmannosylation of Rspo2 may promote cancer progression.

  3. The RSPO2 gene rearrangement leads to oncogenic activation of the Wingless-Type MMTV Integration Site Family signalling pathway in hepatocellular adenomas and hepatocellular carcinoma, represents an alternative mechanism for the development of b-HCA and may drive malignant transformation without additional TERT promoter mutation.

  4. It promotes osteoblastic differentiation of immature human periodontal ligament cells through the Wnt/beta-catenin signaling pathway.

  5. RSPO2 is upregulated in Idiopathic pulmonary fibrosis.

  6. results establish that RSPO2, without the LGR4/5/6 receptors, serves as a direct antagonistic ligand to RNF43 and ZNRF3, which together constitute a master switch that governs limb specification; these findings have direct implications for regenerative medicine and WNT-associated cancers

  7. RSPO2 is a novel target gene of the NOBOX key transcription factor, confirming its important role during the follicular growth in ovary. However, RSPO2 mutations are rare or uncommon in women with primary ovarian insufficiency.

  8. Novel targets ANTXR1 and RSPO2 were confirmed to be suppressed by miR-493 directly.

  9. RSPOs facilitate HSC activation and promote liver fibrogenesis by enhancing the Wnt pathway

  10. Role of RSPO2 in gastric cancer

  11. RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway.

  12. genetic and functional data indicate that RSPO2 is a susceptibility gene for OPLL (Ossification of the Posterior Longitudinal Ligament of the Spine)

  13. Rspo2 was found to have a negative regulatory effect during oxidized low density lipoproteininduced macrophage apoptosis by regulating lipid uptake.

  14. data reveal a RSPO2-induced, LGR5-dependent Wnt signaling-negative feedback loop that exerts a net growth-suppressive effect on CRC cells

  15. results suggest that the expression of RSPO fusion transcripts is related to a subset of colorectal cancers arising in the Japanese population

  16. Wnt(high) cells were more likely to give rise to Wnt(high) progeny, tended to be more metastatic, and revealed higher levels of RSPO2 expression.

  17. These findings suggest that R-Spondin2 may promote hepatic stellate cell activation by enhancing the canonical Wnt pathway.

  18. Oocyte-derived R-spondin2 is a paracrine factor essential for primary ovarian follicle development

  19. using RNA-seq data, identification of multiple fusion transcripts including recurrent gene fusions involving R-spondin family members RSPO2 and RSPO3 that together occur in 10% of colon tumours

  20. Reduced Rspo-2 levels in osteoarthritis osteoblasts are responsible, at least in part, for their reduced Wnt/beta-catenin signaling and abnormal mineralization.

Mouse (Murine) R-Spondin 2 (RSPO2) interaction partners

  1. RSPO2, but not SPON1, specifically promoted the differentiation of midbrain dopaminergic (mDA) neuroblasts into mDA neurons in mouse primary cultures and embryonic stem cells (ESCs).

  2. Rspo2 and Rspo3 fusion events are sufficient to initiate hyperplasia and tumour development.

  3. Data report that Rspo2, is highly expressed in the spinal motor neuron (SMN) and binds to its receptor Lgr5, at the neuromuscular junction (NMJ). Rspo2 enhances the LRP4/MuSK signaling via Lgr5 in an agrin-independent manner and promotes AChR clustering. In addition, the loss of Rspo2 in mice compromises AChR clustering, the ultrastructure of the NMJ, and neuromuscular signal transduction.

  4. LGR4 acted as a key receptor for Rspo2 to promote osteogenesis.

  5. Rspo2 activates Wnt/beta-catenin signaling to reduce Col2a1 and Sox9 and to facilitate differentiation of proliferating chondrocytes into hypertrophic chondrocytes in growth cartilage

  6. High resolution crystal structure of an ectodomain variant of human LGR5 (hLGR5ecto) complexed with a signalling competent fragment of mouse Rspo2.

  7. The endogenously expressed Lgr4 may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin-mediated Lgr4-Wnt signaling during gonadal development.

  8. These findings suggest that R-Spondin2 may promote hepatic stellate cell activation by enhancing the canonical Wnt pathway.

  9. identify the transforming growth factor beta antagonist follistatin as a key mediator of RSPO-LGR4 signaling in myogenic differentiation

  10. R-spondin2 is a key molecular link between infection and intestinal homoeostasis.

  11. R-spondin 2 homolog (Xenopus laevis) is identified as an essential regulator of Citrobacter rodentium infection susceptibility in mice

  12. Oocyte-derived R-spondin2 is a paracrine factor essential for primary ovarian follicle development

  13. Rspo2 is required to limit the number of outer hair cells to three rows and for optimal arrangement of peripheral nerve fibers in the developing cochlea.

  14. Rspo2 mutation in combination with Rspo3 mutation causes severe limb truncation.

  15. Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells.

  16. Results indicate that Rspo2 and Wnt1 have mutually distinct effects on mammary epithelial cell growth and these effects are context-dependent.

  17. Rspo2 is a mesenchyme-derived factor that plays critical roles in regulating branchial arch 1 patterning and morphogenesis through ectodermal-mesenchymal interaction and a novel genetic factor for cleft palate.

  18. The findings suggest that Rspo2 expression in the apical ectodermal ridge (AER) is required for AER maintenance likely by regulating Wnt/beta-catenin signaling.

  19. This study shows that Rspo2 is critical for maintenance of the AER and for growth and patterning in limb development.

  20. Lrp6-mediated R-spondin 2 signaling through the canonical Wnt pathway is required for normal morphogenesis of the respiratory tract and limbs.

R-Spondin 2 (RSPO2) profil antigène

Profil protéine

R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1\; MIM 116806) signaling (Kim et al., 2006

Gene names and symbols associated with anti-R-Spondin 2 (RSPO2) Anticorps

  • R-spondin 2 (Rspo2) anticorps
  • R-spondin 2 L homeolog (rspo2.L) anticorps
  • R-spondin 2 (rspo2) anticorps
  • R-spondin 2 (RSPO2) anticorps
  • 2610028F08Rik anticorps
  • AA673245 anticorps
  • CRISTIN2 anticorps
  • D430027K22 anticorps
  • ftls anticorps
  • RGD1562331 anticorps

Protein level used designations for anti-R-Spondin 2 (RSPO2) Anticorps

R-spondin-2 , XRspo2 , roof plate-specific spondin-2 , activator of Wnt/beta-catenin pathway , R-spondin 2 homolog , R-spondin 2 , cristin-2 , cysteine-rich and single thrombospondin domain-containing protein 2 , mCristin-2

GENE ID SPECIES
500863 Rattus norvegicus
496383 Xenopus laevis
496854 Xenopus (Silurana) tropicalis
536121 Bos taurus
697376 Macaca mulatta
100056523 Equus caballus
340419 Homo sapiens
239405 Mus musculus
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