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In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. De plus, nous expédions RAB35 Anticorps (87) et RAB35 Protéines (7) et beaucoup plus de produits pour cette protéine.
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The authors propose that Rab35-GTP is a critical regulator of autophagy through recruiting autophagy receptor NDP52.
The results provide evidence that MICAL1 plays an essential role in the activation of ROS/Akt signaling and cell invasive phenotype and identify a novel link between RAB35 and MICAL1 in regulating breast cancer cell invasion.
The involvement of Rab35 in diverse and apparently unrelated cellular functions can be explained by the central role of this GTPase in regulating phosphoinositides and F-actin, both on endosomes and at the plasma membrane[review].
Data suggest that Rab35, interacting with TBC1D10A, functions in vascular endothelial cells as a negative regulator of histamine-evoked, Ca2 (Montrer CA2 Kits ELISA)+-dependent Weibel-Palade body exocytosis, most likely acting through the downstream effectors ACAP2 and Arf6 (Montrer ARF6 Kits ELISA). (Rab35 = rab GTP-binding protein 53 (Montrer IGFBP3 Kits ELISA); TBC1D10A = TBC1 domain family member 10A; ACAP2 = centaurin beta2; Arf6 (Montrer ARF6 Kits ELISA) = ADP-ribosylation factor 6 (Montrer ARF6 Kits ELISA))
Short-term EGF (Montrer EGF Kits ELISA) stimulation if of lung tumor cells can increase the interaction between RUSC2 (Montrer RUSC2 Kits ELISA) and GIT2 (Montrer GIT2 Kits ELISA), prolonged stimulation leads to a decrease of their interaction through activating Rab35.
Here the authors report that EspG interacts specifically with the small GTPases ARF6 (Montrer ARF6 Kits ELISA) and Rab35 during infection.
Authors propose that the precise spatial and temporal activation of Rab35 acts as a major switch for OCRL recruitment on newborn endosomes, post-scission PtdIns(4,5)P2 hydrolysis, and subsequent endosomal trafficking.
Rab35 serves as a clathrin-mediated endocytosis detector. Loss of Rab35 input leads to elevated Arf6-GTP and shifts the sorting of clathrin-independent endocytosis cargo proteins to lysosomes.
the activation-inactivation cycles of Rab35 and ARF6 (Montrer ARF6 Kits ELISA) are required for the uptake of zymosan and that ACAP2 is an important component that links Rab35/ARF6 (Montrer ARF6 Kits ELISA) signaling during phagocytosis of zymosan.
Two somatic RAB35 mutations found in human tumors generate alleles that constitutively activate PI3K/AKT signaling, suppress apoptosis, and transform cells in a PI3K-dependent manner.
This study demonstrated that Rab35 regulates Cdc42 (Montrer CDC42 Kits ELISA) activity in neurons.
The Rab35 plays an important role in spindle organization and morphology maintenance, and thus meiotic nuclear maturation.
Rab35 regulates myoblast fusion, a major cellular process under the control of cadherin-dependent signaling.
Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcgammaR-mediated phagocytosis.
The minimal functional Rab35-binding site of RUSC2 (Montrer RUSC2 Kits ELISA) was identified at the amino acid residues 982-1199 and succeeded in developing a novel GTP (Montrer AK3 Kits ELISA)-Rab35-specific trapper.
Rab35 colocalizes with actin filaments and with Cdc42 (Montrer CDC42 Kits ELISA), Rac1 (Montrer RAC1 Kits ELISA) and RhoA (Montrer RHOA Kits ELISA), and that Rab35 can activate Cdc42 (Montrer CDC42 Kits ELISA) both in vivo and in vitro
study found that Rab35 regulates the assembly of actin filaments in filopodia formation; effect was mediated by the actin-bundling protein fascin (Montrer FSCN1 Kits ELISA), which directly associated with active Rab35
In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge.
RAB35, member RAS oncogene family
, ras-related protein Rab-35
, GTP-binding protein RAY
, ras-related protein rab-1c (GTP-binding protein ray)