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RAB4A is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. De plus, nous expédions RAB4A, Member RAS Oncogene Family Anticorps (104) et beaucoup plus de produits pour cette protéine.
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These findings bring attention to the effects of C-terminal carboxylmethylation on RAB (Montrer HRB Protéines) GTPases and provide a rationale for targeting ICMT (Montrer ICMT Protéines) in the treatment of metastatic cancer
The results contradict the model of feedback activation of Rab5 (Montrer RAB5A Protéines) and instead indicate that Rbpt5 is recruited by both Rabex5 (Montrer RABGEF1 Protéines) recognizing ubiquitylated cargo and by Rab4 to activate Rab5 (Montrer RAB5A Protéines) in a feed-forward manner.
Rab4 expression is up-regulated by laminar shear stress, which contributed to improved vascular endothelial cell autophagy and function.
Together the findings indicate that Arl1 (Montrer ARL1 Protéines) links Rab4-dependent formation of endosomal sorting domains with downstream assembly of adaptor protein complexes that constitute the endosomal sorting machinery.
HRES-1/Rab4 regulates autophagy through promoting the formation of LC3 (Montrer MAP1LC3A Protéines)(+) autophagosomes and the preservation of mitochondria.
Data indicate that Rab4 regulates ether-a-go-go-related (Montrer KCNH2 Protéines) gene (hERG (Montrer KCNH2 Protéines)) channel density via neural precursor cell-expressed developmentally down-regulated protein 4 (Montrer NEDD4 Protéines)-2 (Nedd4-2 (Montrer NEDD4L Protéines)).
our findings suggest an evolutionarily conserved function of HDPTP-Rab4 in the regulation of endocytic trafficking, cell adhesion and migration.
TBC1D16 (Montrer TBC1D16 Protéines) is a GTPase activating protein (Montrer RASA1 Protéines) for Rab4A that regulates transferrin receptor recycling and EGFR (Montrer EGFR Protéines) trafficking and signaling.
Upregulated expression of rab4, rab5 (Montrer RAB5A Protéines), rab7 (Montrer RAB7B Protéines) and rab27 (Montrer RAB27A Protéines) correlates with antemortem measures of cognitive decline in individuals with mild cognitive impairment and Alzheimer disease.
Thus down- or up-regulation of Rab4A expression or Rab4A function triggered inhibition or increase of procathepsin L secretion respectively.
Insulin (Montrer INS Protéines)-dependent Rab4a redistribution, probably reflecting stimulation of vesicle-mediated transport, is inhibited in adipocytes subjected to differentiation in the presence of IL-6 (Montrer IL6 Protéines), IL-8 (Montrer IL8 Protéines), or IL-15 (Montrer IL15 Protéines).
Reduced Akt2 (Montrer AKT2 Protéines) leads to up-regulation of Rab4a expression in cardiomyocytes in a cell-autonomous fashion that may involve activation of PPARalpha (Montrer PPARA Protéines).
insulin (Montrer INS Protéines) signaling stimulates Rab4 activity, the association of Rab4 with kinesin, the interaction of KIF3 (Montrer KIF3A Protéines) with microtubules and this process is mediated by insulin (Montrer INS Protéines)-induced PI3-kinase (Montrer PIK3CA Protéines)-dependent PKC-lambda activation and participates in GLUT4 (Montrer SLC2A4 Protéines) exocytosis
p85alpha protein may play a role in the down-regulation of activated receptors through its temporal control of the GTPase (Montrer RACGAP1 Protéines) cycles of Rab5 (Montrer RAB5A Protéines) and Rab4
Rab4 is a rate-limiting factor for the recycling of endogenous beta-AR; and augmentation of Rab4-mediated traffic enhances beta-AR function in cardiac myocytes
Rabip4s, possibly via their interaction with Rab4, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts
Sorting of PDGF (Montrer PDGFA Protéines) beta-receptors on early endosomes is regulated by sequential activation of PKCalpha (Montrer PKCa Protéines) and Rab4a and that this sorting step could constitute a point of cross-talk with other receptors.
Receptor recycling is mediated by AP-1 (Montrer JUN Protéines)/clathrin-coated vesicles and regulated by rab4 and rabaptin-5/rabex-5 (Montrer RABGEF1 Protéines).
This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene.
RAB4A, member RAS oncogene family
, ras-related protein Rab-4A
, Ras-related small GTP binding protein 4