RAB4A, Member RAS Oncogene Family Protéines (RAB4A)

RAB4A is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. De plus, nous expédions RAB4A, Member RAS Oncogene Family Anticorps (110) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
RAB4A 5867 P20338
RAB4A 19341 P56371
RAB4A 25532 P05714
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$888.80
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Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 15 to 19 Days
$400.00
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Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,541.00
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Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,541.00
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Escherichia coli (E. coli) Humain GST-His-Tag   50 μg Connectez-vous pour afficher 6 to 7 Days
$300.81
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RAB4A Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour RAB4A, Member RAS Oncogene Family (RAB4A) partenaires d'interaction

Human RAB4A, Member RAS Oncogene Family (RAB4A) interaction partners

  1. These findings bring attention to the effects of C-terminal carboxylmethylation on RAB GTPases and provide a rationale for targeting ICMT in the treatment of metastatic cancer

  2. The results contradict the model of feedback activation of Rab5 and instead indicate that Rbpt5 is recruited by both Rabex5 recognizing ubiquitylated cargo and by Rab4 to activate Rab5 in a feed-forward manner.

  3. Rab4 expression is up-regulated by laminar shear stress, which contributed to improved vascular endothelial cell autophagy and function.

  4. Together the findings indicate that Arl1 links Rab4-dependent formation of endosomal sorting domains with downstream assembly of adaptor protein complexes that constitute the endosomal sorting machinery.

  5. HRES-1/Rab4 regulates autophagy through promoting the formation of LC3(+) autophagosomes and the preservation of mitochondria.

  6. Data indicate that Rab4 regulates ether-a-go-go-related gene (hERG) channel density via neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2).

  7. our findings suggest an evolutionarily conserved function of HDPTP-Rab4 in the regulation of endocytic trafficking, cell adhesion and migration.

  8. TBC1D16 is a GTPase activating protein for Rab4A that regulates transferrin receptor recycling and EGFR trafficking and signaling.

  9. Upregulated expression of rab4, rab5, rab7 and rab27 correlates with antemortem measures of cognitive decline in individuals with mild cognitive impairment and Alzheimer disease.

  10. Thus down- or up-regulation of Rab4A expression or Rab4A function triggered inhibition or increase of procathepsin L secretion respectively.

  11. Overexpression of Rab4 regulates angiotensin II type I receptor phosphorylation and sensitization.

  12. Findings substantiate the notion that modulation of the temporal and spatial distribution of P-gp in cancer cells may be a valid therapeutic strategy to alleviate the MDR phenotype, and signal to Rab4 as a potential target.

  13. These findings suggest that Rab14 and Rab4 act sequentially, together with RUFY1.

  14. NDRG1 specifically interacts with constitutively active Rab4aQ67L mutant protein and not with GDP-bound Rab4aS22N mutant proving NDRG1 as a novel Rab4a effector

  15. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein

  16. Data suggest that abnormal membrane recycling in Niemann-Pick type A and C lipid storage disease fibroblasts results from specific inhibition of rab4 function by excess cholesterol in early endosomes.

  17. In contrast to Rab11, Rab4 is not involved in exocytosis

  18. Rab4 specific residue His39 modulates the nucleotide binding pocket giving rise to a reduced rate for nucleotide hydrolysis and exchange

  19. critical element that regulates epithelial sodium channel (ENaC) function by GTP-GDP recycling and concomitant changes in ENaC expression at the cell surface and in intracellular pool

  20. The study suggests that Rab4 regulates the channel through multiple mechanisms that include protein-protein interaction, GTP/GDP exchange, and channel protein trafficking.

Mouse (Murine) RAB4A, Member RAS Oncogene Family (RAB4A) interaction partners

  1. Insulin-dependent Rab4a redistribution, probably reflecting stimulation of vesicle-mediated transport, is inhibited in adipocytes subjected to differentiation in the presence of IL-6, IL-8, or IL-15.

  2. Reduced Akt2 leads to up-regulation of Rab4a expression in cardiomyocytes in a cell-autonomous fashion that may involve activation of PPARalpha.

  3. insulin signaling stimulates Rab4 activity, the association of Rab4 with kinesin, the interaction of KIF3 with microtubules and this process is mediated by insulin-induced PI3-kinase-dependent PKC-lambda activation and participates in GLUT4 exocytosis

  4. p85alpha protein may play a role in the down-regulation of activated receptors through its temporal control of the GTPase cycles of Rab5 and Rab4

  5. Rab4 is a rate-limiting factor for the recycling of endogenous beta-AR; and augmentation of Rab4-mediated traffic enhances beta-AR function in cardiac myocytes

  6. Rabip4s, possibly via their interaction with Rab4, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts

  7. Sorting of PDGF beta-receptors on early endosomes is regulated by sequential activation of PKCalpha and Rab4a and that this sorting step could constitute a point of cross-talk with other receptors.

Cow (Bovine) RAB4A, Member RAS Oncogene Family (RAB4A) interaction partners

  1. Receptor recycling is mediated by AP-1/clathrin-coated vesicles and regulated by rab4 and rabaptin-5/rabex-5.

Profil protéine RAB4A, Member RAS Oncogene Family (RAB4A)

Profil protéine

This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene.

Gene names and symbols associated with RAB4A

  • RAB4A, member RAS oncogene family (rab4a)
  • RAB4a, member RAS oncogene family (rab4a)
  • RAB4A, member RAS oncogene family (RAB4A)
  • RAB4A, member RAS oncogene family (Rab4a)
  • AI848268 Protéine
  • fc93b03 Protéine
  • HRES-1/RAB4 Protéine
  • MGC52945 Protéine
  • Rab4 Protéine
  • RAB4A Protéine
  • wu:fc93b03 Protéine

Protein level used designations for RAB4A

RAB4A, member RAS oncogene family , ras-related protein Rab-4A , Ras-related small GTP binding protein 4

GENE ID SPECIES
380363 Xenopus laevis
403031 Danio rerio
421532 Gallus gallus
479210 Canis lupus familiaris
100302066 Ovis aries
100341137 Oryctolagus cuniculus
5867 Homo sapiens
19341 Mus musculus
25532 Rattus norvegicus
615849 Bos taurus
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