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The protein encoded by RAD18 is highly similar to S. De plus, nous expédions RAD18 Anticorps (114) et RAD18 Kits (2) et beaucoup plus de produits pour cette protéine.
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Human RAD18 Protein expressed in HEK-293 Cells - ABIN2730398
Zlatanou, Sabbioneda, Miller, Greenwalt, Aggathanggelou, Maurice, Lehmann, Stankovic, Reverdy, Colland, Vaziri, Stewart: USP7 is essential for maintaining Rad18 stability and DNA damage tolerance. dans Oncogene 2016
Rad18, independently of its ubiquitin ligase activity, promotes DNA polymerase eta (Montrer POLH Protéines) SUMOylation by facilitating its interaction with its SUMO ligase PIAS1 (Montrer PIAS1 Protéines) and is required for DNA polymerase eta (Montrer POLH Protéines) function at difficult to replicate loci.
MAGE-A4 (Montrer MAGEA4 Protéines) depletion from MAGE-A4 (Montrer MAGEA4 Protéines)-expressing cancer cells destabilizes RAD18.
Data suggest that, as part of DNA repair in nucleus of embryonic stem cells, IGF1R interacts with and phosphorylates PCNA at tyrosine residues 60, 133, and 250; this is followed by mono- and polyubiquitination of PCNA by RAD18 and SHPRH. (IGF1R = insulin-like growth factor 1 receptor; PCNA = proliferating cell nuclear antigen; RAD18 = E3 ubiquitin-protein ligase RAD18; SHPRH = E3 ubiquitin-protein ligase SHPRH)
Ubiquitin ligases RNF168 (Montrer RNF168 Protéines), RNF169 (Montrer RNF169 Protéines), and RAD18 specifically bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1 (Montrer TP53BP1 Protéines) chromatin recruitment may be activated by RNF168 (Montrer RNF168 Protéines) and blocked by RNF169 (Montrer RNF169 Protéines) and RAD18.
WRNIP1 (Montrer WRNIP1 Protéines) connects PCNA (Montrer PCNA Protéines) monoubiquitination with ATMIN (Montrer ATMIN Protéines)/ATM (Montrer ATM Protéines) to activate ATM (Montrer ATM Protéines) signalling in response to replication stress and contribute to the maintenance of genomic stability.
RAD18 polymorphisms are correlated with the side effects of platinum-chemotherapy in Chinese patients with advanced NSCLC.
REV1 (Montrer REV1 Protéines) can promote (Montrer PCNA Protéines)PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.
USP7 (Montrer USP7 Protéines)-mediated de-ubiquitylation protects Rad18 from proteasomal degradation and is necessary for the integrity of the specialized translesion synthesis pathway
RAD18 can function as a mediator for DNA damage response signals to activate the G2/M checkpoint in order to maintain genome integrity and cell survival after IR exposure.
Significantly restored tolerance of RAD18-/- and RNF8 (Montrer RNF8 Protéines)-/- cells to camptothecin and olaparib without affecting Rad51 (Montrer RAD51 Protéines) focus formation.
Somatic hypermutation of immunoglobulin genes (SHM (Montrer CNTNAP1 Protéines)) in Rad18 KO mice was similar to wild-type mice, suggesting that Rad18 is dispensable for SHM (Montrer CNTNAP1 Protéines).
Rad18 confers DNA damage tolerance and tumor-suppression in a physiological setting.
REV1 promote PCNA (Montrer PCNA Protéines) monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.
RAD18 contributes to maintenance of genomic stability through postreplication repair
Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase
Rad18 suppresses viral infection in a non-specific fashion, probably by targeting incoming DNA.
RAD18 is intrinsically required for the long-term maintenance of spermatogenesis.
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
E3 ubiquitin-protein ligase RAD18
, RAD18, S. cerevisiae, homolog
, RING finger protein 73
, postreplication repair protein RAD18
, postreplication repair protein hRAD18p
, post-replication repair protein RAD18SC
, RAD18 homolog (S. cerevisiae)
, similar to postreplication repair protein hRAD18p
, E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair
, hypothetical protein
, DNA repair protein and ATPase
, SAP DNA-binding domain-containing protein
, RAD18 homolog
, RAD18-like protein
, E3 ubiquitin-protein ligase RAD18-like
, e3 ubiquitin-protein ligase RAD18-like