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May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. De plus, nous expédions RAD51AP1 Anticorps (43) et et beaucoup plus de produits pour cette protéine.
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RAD51AP1 upregulation is described in both tissue and matching blood from patients with ovarian and lung cancer compared with healthy controls.
The current understanding of the biochemical and biological functions of RAD51AP1 as HR factor is reviewed. It is also discussed how RAD51AP1 may help to promote cancer development and potentially be a promising new target for therapeutic intervention. [REVIEW]
USP1 (Montrer USP1 Protéines)-UAF1 (Montrer WDR48 Protéines) complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 deubiquitination, as well as by interacting with RAD51AP1.
RAD51AP1 is required for the maintenance of DNA replication fork progression.
Data suggest that microRNA/mRNA pairs in hsa (Montrer CD24 Protéines)-miR (Montrer MLXIP Protéines)-140-3p/RAD51AP1/, hsa (Montrer CD24 Protéines)-miR (Montrer MLXIP Protéines)-145/E2F3, hsa (Montrer CD24 Protéines)-miR (Montrer MLXIP Protéines)-139-5p/TOP2A (Montrer TOP2A Protéines), and hsa (Montrer CD24 Protéines)-miR (Montrer MLXIP Protéines)-133a/GCLC (Montrer GCLC Protéines) were correlated with ovarian tumorigenesis.
We have finely mapped the two DNA binding domains in RAD51AP1 and using mutant variants, reveal that both domains are indispensable for RAD51AP1 function in cells.
RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase (Montrer RAG1 Protéines) DMC1 (Montrer DMC1 Protéines) through a conserved motif.
RAD51AP1 foci colocalize with a subset of DMC1 (Montrer DMC1 Protéines) foci in spermatocytes.
Although PALB2 (Montrer PALB2 Protéines) alone stimulates D-loop formation, it has a cooperative effect with RAD51AP1, an enhancer of RAD51 (Montrer RAD51 Protéines).
expression of three (Beclin 1 (Montrer BECN1 Protéines), RbAp48 (Montrer RBBP4 Protéines) and Pir51) were increased and one (aldolase b (Montrer ALDOB Protéines)) was decreased in liver tumor tissues
VipD of Legionella pneumophila targets activated Rab5 (Montrer RAB5A Protéines) and Rab22 to interfere with endosomal trafficking in macrophages.
May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA (By similarity).
RAD51-associated protein 1
, RAD51-interacting protein