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ARID4B encodes a protein with sequence similarity to retinoblastoma-binding protein-1. De plus, nous expédions BRCAA1 Anticorps (39) et et beaucoup plus de produits pour cette protéine.
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miR-519b-3p directly binds to the 3' UTR of ARID4B mRNA whose expression was inversely correlated with miR-519b-3p expression.
ARID4B overexpression presented in most of primary brain tumors, rather than non-neoplastic brain tissue, and correlated with WHO grades in meningiomas and gliomas.
ARID4B was significantly elevated in the serum of excessive alcohol users.
Consistent with our genetic analysis and in vivo experiments in our mouse model system, ARID4B expression was also an independent predictor of distant metastasis-free survival in breast cancer patients with ER+ tumors
Immunohistochemistry analysis showed that the antigen epitope exhibited positive expression in 65% (39 of 60) breast cancer specimens and negative expression in 60 non-cancerous tissues. A novel breast cancer antigen epitope, SSKKQKRSHK, is identified
These results identified ARID4B as a master regulator of a signaling network that governs the establishment of a niche during the critical gonocyte-to-spermatogonial stem cells (SSC) transition phase to control the fate of gonocytes and SSCs.
The study identified ARID4B to be a key regulator of Sertoli cell function important for male germ cell development.
ARID4A and ARID4B function as transcriptional coactivators for AR and RB and play an integral part in the AR and RB regulatory pathways involved in the regulation of Sertoli cell function and male fertility.
These studies support a causative role of ARID4B in metastatic progression of breast cancer.
10 of 12 Arid4a(-/-)Arid4b(+/-) mice progressed to acute myeloid leukemia (AML) and had rapid further increases of leukocyte counts.
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.
180 kDa Sin3-associated polypeptide
, ARID domain-containing protein 4B
, AT-rich interactive domain-containing protein 4B
, histone deacetylase complex subunit SAP180
, retinoblastoma-binding protein 1-like 1
, retinoblastoma-binding protein 1-related protein
, sin3-associated polypeptide p180
, Rb-binding protein homolog
, SIN3A-associated protein 180
, breast cancer-associated antigen 1
, breast cancer-associated antigen BRCAA1
, breast carcinoma-associated antigen
, AT rich interactive domain 4B (Rbp1 like)
, RBP1-like protein
, breast cancer-associated antigen
, retinoblastoma binding protein 1-like 1