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RBM10 encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. De plus, nous expédions RBM10 Anticorps (44) et RBM10 Protéines (4) et beaucoup plus de produits pour cette protéine.
RBM10 functions as a splicing regulator (Montrer PTBP2 Kits ELISA) using two RNA-binding units with different specificities to promote exon skipping.
RNA binding motif protein 10 (RBM10) negatively regulates its own mRNA and protein expression and that of RNA binding motif protein 5 (RBM5 (Montrer RBM5 Kits ELISA)) by promoting alternative splicing-coupled nonsense-mediated mRNA decay (AS-NMD).
results provide evidence that RBM10 expression, in RBM5 (Montrer RBM5 Kits ELISA)-null tumors, may contribute to tumor growth and metastasis. Measurement of both RBM10 and RBM5 (Montrer RBM5 Kits ELISA) expression in clinical samples may therefore hold prognostic and/or potentially predictive value
RBM10-TFE3 is a recurrent gene fusion in Xp11 translocation renal cell carcinoma.
Xp11 translocation renal cell carcinomas with RBM10-TFE3 (Montrer TFE3 Kits ELISA) gene fusion demonstrating melanotic features and overlapping morphology with t(6;11) RCC (Montrer XRCC1 Kits ELISA).
RBM10-TFE3 (Montrer TFE3 Kits ELISA) fusion variant (from chromosome X paracentric inversion), therefore, appears to be a recurrent molecular event in Xp11.2 RCCs. RBM10-TFE3 (Montrer TFE3 Kits ELISA) fusion should be added in the list of screened fusion transcripts in targeted molecular diagnostic multiplex RT-PCR
RBM10 is a tumor suppressor that represses Notch (Montrer NOTCH1 Kits ELISA) signaling and cell proliferation through the regulation of NUMB (Montrer NUMB Kits ELISA) alternative splicing
Src (Montrer SRC Kits ELISA) family tyrosine kinase (Montrer TXK Kits ELISA) signaling may regulate FilGAP (Montrer ARHGAP24 Kits ELISA) through association with RBM10
The ability of RBM10v1 to regulate alternative splicing depends, at least in part, on a structural alteration within the second RNA recognition motif domain, and correlates with preferential expression of the NUMB (Montrer NUMB Kits ELISA) exon 11 inclusion variant.
RBM10 regulates alternative splicing of Fas (Montrer FAS Kits ELISA) and Bcl-x (Montrer BCL2L1 Kits ELISA) genes.
These results demonstrate a role for RBM10 in the regulation of alternative splicing in two cell models of mouse early development and suggests that mutations in RBM10 could lead to splicing changes that affect normal palate development and cause human disease.
Expression of Rbm5 (Montrer RBM5 Kits ELISA) and Rbm10 RNA remained constant during C2C12 myogenesis, but protein levels significantly decreased.
S1-1 constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner; upon globally reducing RNA polymerase II transcription, S1-1 nuclear bodies enlarge and decrease in number.
This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.
RNA binding motif protein 10
, RNA-binding protein 10-like
, RNA-binding protein 10
, RNA-binding protein S1-1
, g patch domain-containing protein 9
, RNA-binding motif protein 10
, S1-1 protein from liver