Ras Homolog Gene Family, Member T2 Protéines (RHOT2)

RHOT2 encodes a member of the Rho family of GTPases. De plus, nous expédions Ras Homolog Gene Family, Member T2 Anticorps (38) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
RHOT2 89941 Q8IXI1
Rat RHOT2 RHOT2 287156 Q7TSA0
RHOT2 214952 Q8JZN7
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,626.01
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,355.45
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$547.80
Détails

RHOT2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, , ,
Mouse (Murine)
,

Plus protéines pour Ras Homolog Gene Family, Member T2 (RHOT2) partenaires d'interaction

Human Ras Homolog Gene Family, Member T2 (RHOT2) interaction partners

  1. Show that the C-terminal GTPase of the Parkin primary substrates Miro1 and Miro2 are necessary and sufficient for efficient ubiquitination. We present several new X-ray crystal structures of both Miro1 and Miro2 that reveal substrate recognition and ubiquitin transfer to be specific to particular protein domains and lysine residues.

  2. Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells.

  3. The Miro2-mediated mitochondrial transport in neurons and recently highlighted involvement of Miro2 proteins in mitochondrial turnover, emerging as a key process affected in neurodegeneration.

  4. Study shows that both PINK1 (Montrer PINK1 Protéines) and Parkin (Montrer PARK2 Protéines) halt mitochondrial movement; PINK1 (Montrer PINK1 Protéines) phosphorylates Miro (1 (Montrer RHOT1 Protéines) and 2) and thereby initiates the rapid degradation of Miro through a Parkin (Montrer PARK2 Protéines)- and proteasome-dependent pathway.

  5. Moreover, we show that Miro interacts with the Kinesin-binding proteins, GRIF-1 and OIP106 (Montrer TRAK1 Protéines), suggesting that the Miro GTPases form a link between the mitochondria and the trafficking apparatus of the microtubules.

  6. Miro proteins serve as a [Ca(2 (Montrer CA2 Protéines)+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria.

Mouse (Murine) Ras Homolog Gene Family, Member T2 (RHOT2) interaction partners

  1. both Miro proteins can act to coordinate microtubule-dependent and actin-dependent mitochondrial trafficking, Miro1 (Montrer RHOT1 Protéines) preferentially acts to control microtubule-dependent trafficking through kinesin and dynein, while Miro2 plays a more prominent role in coordinating mitochondrial interactions with the actin cytoskeleton through a more efficient recruitment and stability of endogenous Myo19 (Montrer MYO19 Protéines) in the mitochondrial membrane.

  2. Using mouse knockout strategies, we demonstrate that Miro1 (Montrer RHOT1 Protéines), as opposed to Miro2, is the primary regulator of mitochondrial transport in both axons and dendrites. Miro1 (Montrer RHOT1 Protéines) deletion leads to depletion of mitochondria from distal dendrites but not axons, accompanied by a marked reduction in dendritic complexity. Disrupting postnatal mitochondrial distribution in vivo by deleting Miro1 (Montrer RHOT1 Protéines) in mature neurons causes a progressive loss

  3. Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1/2 and Trak2.

  4. molecular cloning and characterization of a novel mouse cDNA encoding a putative atypical GTPase (Montrer RACGAP1 Protéines) protein, Arht2

Profil protéine Ras Homolog Gene Family, Member T2 (RHOT2)

Profil protéine

This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics.

Gene names and symbols associated with RHOT2

  • ras homolog family member T2 (RHOT2)
  • ras homolog family member T2 (Rhot2)
  • ras homolog family member T2 (rhot2)
  • Arht2 Protéine
  • C16orf39 Protéine
  • DKFZp459P0951 Protéine
  • MIRO-2 Protéine
  • Miro2 Protéine
  • RASL Protéine
  • RHOT2 Protéine
  • zgc:123249 Protéine

Protein level used designations for RHOT2

ras homolog gene family, member T2 , mitochondrial Rho GTPase 2-like , mitochondrial Rho (MIRO) GTPase 2 , mitochondrial Rho GTPase 2 , MIRO-2 , miro protein , mitochondrial Rho 2 , ras homolog gene family member T2 , rho GTPase

GENE ID SPECIES
453800 Pan troglodytes
479893 Canis lupus familiaris
100066937 Equus caballus
100294664 Pongo abelii
100395876 Callithrix jacchus
89941 Homo sapiens
287156 Rattus norvegicus
352959 Bos taurus
427651 Gallus gallus
397596 Sus scrofa
214952 Mus musculus
557574 Danio rerio
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