Regulatory Factor X, 1 (Influences HLA Class II Expression) Protéines (RFX1)

RFX1 is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. De plus, nous expédions Regulatory Factor X, 1 (Influences HLA Class II Expression) Anticorps (41) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
RFX1 5989 P22670
RFX1 19724 P48377
Rat RFX1 RFX1 288906  
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Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
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Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$932.80
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RFX1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour Regulatory Factor X, 1 (Influences HLA Class II Expression) (RFX1) partenaires d'interaction

Human Regulatory Factor X, 1 (Influences HLA Class II Expression) (RFX1) interaction partners

  1. RFX1 interacts with the D sequence of adeno-associated virus inverted terminal repeat and regulates AAV transduction.

  2. RFX1 expression was significantly lower in HCC tissues compared to the corresponding non-tumor tissues. In vitro studies suggested that knocking down RFX1 facilitated HCC cell invasion, while overexpression of RFX1 reduced the invasion of HCC cells. RFX1 regulated expression of some epithelial-mesenchymal transition markers.

  3. Findings indicate that RFX1 functions downstream of STAT3 and phosphorylated STAT3 can inhibit RFX1 expression and suggest a unique role for RFX1 in Th17-related autoimmune diseases.

  4. Results show that reduced miRNA-124 improved microglia activation and up-regulated its downstream target RFX1, indicating that RFX1, as one of the target transcripts, facilitates microglial activation by miR-124 regulation; identified the binding site through which RFX1 directly regulates ApoE, may explain the missing link between decreased miRNA-124 and ineffective Abeta uptaking during aging.

  5. induction of ciliogenesis increases the expression of RFX and dyslexia candidate genes

  6. Data show that transcription factor regulatory factor X 1 (RFX1) protein expression can be tightly regulated by polyubiquitination-mediated proteosomal degradation via STIP1 homology and U-box containing protein 1 (STUB1).

  7. therapeutic targets for childhood severe asthmatics identified thru DNA microarray

  8. Data indicate that regulatory factor X transcription factor RFX-1 regulates SC-2001-mediated SHP-1 Phosphatase transcription in hepatocellular carcinoma cells.

  9. regulatory factor 1 directly regulates CD44 expression in glioblastoma

  10. Taken together, this study suggests ciliogenic RFX transcription factors regulate FGF-1B promoter activity and the maintenance of F1BGFP(+) NSPCs and GBM-SCs.

  11. RFX1 reduces cell proliferation through inhibiting the TGFbeta2-ERK signaling pathway. RFX1 blocks TGFbeta2 expression through its direct action on TGFbeta2 transcription.

  12. NLRC5-mediated histocompatibiility class I gene induction requires the W/S and X1, X2 cis-regulatory elements.

  13. in serum- or IGF-1-stimulated breast cancer MCF-7 cells, JNK induces SHP1 expression through the binding of AP-4 and RFX-1 transcription factors to the epithelial tissue-specific SHP1 promoter.

  14. RFX1 recruits SUV39H1 to the promoter regions of the CD11a and CD70 genes in CD4(+) T cells, thereby regulating local H3K9 tri-methylation levels.

  15. regulates autoimmunity via epigenetic modifications in T cells of systemic lupus erythematosus patients

  16. We show binding of RFX proteins to an evolutionarily conserved X-box in the ALMS1 proximal promoter and present evidence that these proteins are responsible for ALMS1 transc

  17. RFX1 may negatively regulate the self-renewal of GBM-SCs through modulating FGF-1B and FGF1 expression levels by binding the 18-bp cis-elements of the F1B promoter.

  18. Data show that two regulatory factor for X box (RFX1 and 3) binding sites in exon1 of both the mouse and human microtubule-associated protein (MAP1A) gene are important for effective transcriptional repression in non-neuronal cells.

  19. Disruption of the RFX site within 263P blunts repressor activity in transfected GC cells; however, repression is only abolished when both PSE-A/RFX and PSE-B/NF-1 sites are mutated.

  20. novel role for the RFX family of transcription factors as modulators of Ras signalling in epithelial cells

Mouse (Murine) Regulatory Factor X, 1 (Influences HLA Class II Expression) (RFX1) interaction partners

  1. RFX1 transcriptionally targets Itga6 in Sertoli cells, thereby, helping maintain the integrity of the basal lamina during testis cord development.

  2. Results show that reduced miRNA-124 improved microglia activation and up-regulated its downstream target RFX1, indicating that RFX1, as one of the target transcripts, facilitates microglial activation by miR-124 regulation; identified the binding site through which RFX1 directly regulates ApoE, may explain the missing link between decreased miRNA-124 and ineffective Abeta uptaking during aging.

  3. This study suggests that ciliogenic Rfx transcription factors regulate Msi1 expression in neural stem/progenitor cells.

  4. regulatory factor 1 directly regulates CD44 expression in glioblastoma

  5. RFX1 may have negative effect on cell proliferation of Sertoli cells via modulating Spata4 expression levels by binding the conserved 14-bp cis-elements of Spata4 promoter.

  6. Rfx1 could be an indicator of progression from Barrett's esophagus to adenocarcinoma.

  7. These results suggest a significant expression of RFX1 proteins in the mammalian brain.

  8. RFX1 may negatively regulate the self-renewal of GBM-SCs through modulating FGF-1B and FGF1 expression levels by binding the 18-bp cis-elements of the F1B promoter.

  9. RFX1 may play roles in haploid cells during mouse spermatogenesis

  10. RFX1 mediates the immediate early response of the Id2 gene by serum stimulation and suggest that the function of RFX1 is regulated intramolecularly in its suppression in growth-arrested cells.

  11. RFX1 regulates expression of genes that are essential for early embryonic development/survival and that RFX1 function can not be compensated by other RFX1 family members.

Profil protéine Regulatory Factor X, 1 (Influences HLA Class II Expression) (RFX1)

Profil protéine

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.

Gene names and symbols associated with RFX1

  • regulatory factor X1 (RFX1)
  • regulatory factor X, 1 (influences HLA class II expression) (Rfx1)
  • regulatory factor X1 (Rfx1)
  • regulatory factor X, 1a (influences HLA class II expression) (rfx1a)
  • AI047719 Protéine
  • AI385641 Protéine
  • EFC Protéine
  • RFX Protéine
  • zgc:162914 Protéine

Protein level used designations for RFX1

MHC class II regulatory factor RFX , MHC class II regulatory factor RFX1 , enhancer factor C , regulatory factor X 1 , trans-acting regulatory factor 1 , transcription factor RFX1 , vregulatory factor X, 1 (influences HLA class II expression) , regulatory factor X1

GENE ID SPECIES
5989 Homo sapiens
19724 Mus musculus
288906 Rattus norvegicus
484908 Canis lupus familiaris
789747 Bos taurus
100736012 Cavia porcellus
100038773 Danio rerio
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