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RPN2 encodes a type I integral membrane protein found only in the rough endoplasmic reticulum.
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RPN13 binds ubiquitin with an affinity similar to that of other proteasome-associated ubiquitin receptors and that RPN2, ubiquitin, and the deubiquitylase UCH37 bind to RPN13 with independent energetics.
RPN2 (Montrer PSMD1 Kits ELISA) expression correlates with gastric adenocarcinoma cell invasion and shows promise as a new prognostic factor in human gastric adenocarcinoma
Data suggest that RPN2 (Montrer PSMD1 Kits ELISA) is involved in the regulation of lethal cancer phenotypes and represents a promising new target for RNAi-based medicine against non-small cell lung cancer.
Together, our findings suggest that the interaction of Psmd1 (Montrer PSMD1 Kits ELISA) with Adrm1 (Montrer Adrm1 Kits ELISA) is controlled by SUMOylation in a manner that may alter proteasome composition and function.
Of the total, the deregulation of several genes (CDK1 (Montrer CDK1 Kits ELISA), CDK2 (Montrer CDK2 Kits ELISA), CDK4 (Montrer CDK4 Kits ELISA), MCM2 (Montrer MCM2 Kits ELISA), MCM3 (Montrer MCM3 Kits ELISA), MCM4 (Montrer MCM4 Kits ELISA), EIF3a (Montrer EIF6 Kits ELISA) and RPN2 (Montrer PSMD1 Kits ELISA)) were potentially associated with disease development and progression.
these results indicated that high glycosylation of CD63 (Montrer CD63 Kits ELISA) by RPN2 (Montrer PSMD1 Kits ELISA) is implicated in clinical outcomes in breast cancer patients
Increased 26S proteasome non-ATPase regulatory subunit 1 (Montrer PSMD1 Kits ELISA) in the aqueous humor of patients with age-related macular degeneration compared to control subjects.
Furthermore, our study reveals that high expression of RPN2 (Montrer PSMD1 Kits ELISA) and concomitant accumulation of mtp53 were associated with cancer tissues in a small cohort of metastatic breast cancer patients.
The 26S proteasome (Montrer Psmd4 Kits ELISA) plays a key role in promoting apoptosis induced by high doses of UV irradiation.
p38 MAPK (Montrer MAPK14 Kits ELISA) negatively regulates the proteasome activity by phosphorylating Thr (Montrer TRH Kits ELISA)-273 of Rpn2 (Montrer PSMD1 Kits ELISA)
S-glutathionylation of Rpn2 is a contributory mechanism for H2O2-induced inhibition of 26 S proteasomal function
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
26S proteasome non-ATPase regulatory subunit 1
, 26S proteasome regulatory subunit RPN2
, 26S proteasome regulatory subunit S1
, 26S proteasome subunit p112
, dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit
, dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
, oligosaccharyltransferase complex subunit (non-catalytic)
, ribophorin 2
, ribophorin II
, ribophorin ii
, dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like
, ribophorin II S homeolog