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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
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Human Polyclonal RPL11 Primary Antibody pour ELISA, WB - ABIN1327647
Hagner, Mazan-Mamczarz, Dai, Balzer, Corl, Martin, Zhao, Gartenhaus: Ribosomal protein S6 is highly expressed in non-Hodgkin lymphoma and associates with mRNA containing a 5' terminal oligopyrimidine tract. dans Oncogene 2011
PICT-1 is a major nucleolar sensor of the DNA damage repair response and an important upstream regulator of p53 (Montrer TP53 Anticorps) via the RPL11-MDM2 (Montrer MDM2 Anticorps)-p53 (Montrer TP53 Anticorps) pathway.
A novel pathogenic mutation in RPL11 identified in a patient diagnosed with diamond Blackfan anemia as a young adult.
RPL splicing variant is associated with Diamond-Blackfan anemia.
Simulation of HEY1 (Montrer HEY1 Anticorps) Ser (Montrer SIGLEC1 Anticorps)-68 phosphorylation prevents its interaction with p53 (Montrer TP53 Anticorps), RPL11 and MDM2 (Montrer MDM2 Anticorps) and abolishes HEY1 (Montrer HEY1 Anticorps) migration to nucleolar caps (Montrer CAPS Anticorps) upon ribosomal stress. Our findings uncover a novel mechanism for cross-talk between Notch (Montrer NOTCH1 Anticorps) signalling and nucleolar stress
Data suggest 5S ribosomal RNA is a direct target of miR (Montrer MLXIP Anticorps)-150 and miR (Montrer MLXIP Anticorps)-383 in esophageal squamous cell carcinoma (ESCC); overexpression of miR (Montrer MLXIP Anticorps)-150 and miR (Montrer MLXIP Anticorps)-383 inhibits ESCC cell proliferation in vitro and in vivo and intensifies RPL11/c-Myc (Montrer MYC Anticorps) interaction.
Ribosomal proteins L11 and L5 activate TAp73 (Montrer TP73 Anticorps) by overcoming MDM2 (Montrer MDM2 Anticorps) inhibition.
Data indicate that ribosomal protein (L11) promotes the recruitment of microRNA-130a (miR (Montrer MLXIP Anticorps)-130a) to oncoprotein c-Myc (Montrer MYC Anticorps) in response to UV irradiation treatment.
Data indicate that ribosomal protein L11 (RPL11)-expressing cells proliferated more rapidly than the ribosomal protein L11 (RPL11)-expressing cells.
Findings uncover a mechanism by which RPL5 (Montrer RPL5 Anticorps) and RPL11 can co-operatively suppress c-Myc (Montrer MYC Anticorps) expression, allowing a tightly controlled ribosome biogenesis in cells.
levels of branched-chain aminotransferase-1 (BCAT1 (Montrer BCAT1 Anticorps)) transcripts are significantly decreased on the polysomes of both RPS19 (Montrer RPS19 Anticorps) and RPL11 cells and that translation of BCAT1 (Montrer BCAT1 Anticorps) protein is especially impaired in cells with small RP gene mutations
there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2 (Montrer MDM2 Anticorps)/p53 (Montrer TP53 Anticorps) axis which is important in normal hematopoiesis.
The association of the L11 and Mdm2 (Montrer MDM2 Anticorps) is resulted the activation of the pathway in embryonic stem cells.
ribosomal dysfunction due to the loss of L11 activates a p53 (Montrer TP53 Anticorps)-dependent checkpoint response to prevent improper embryonic development.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
60S ribosomal protein L11
, CLL-associated antigen KW-12
, cell growth-inhibiting protein 34
, ribosomal protein L11
, ribosomal protein DL11
, ribosomal protein L11 L homeolog