Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Kits ELISA

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. De plus, nous expédions RUNX1T1 Anticorps (51) et RUNX1T1 Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
Anti-Rat RUNX1T1 RUNX1T1 362489  
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
$810.17
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Souris < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
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Plus Kits ELISA pour RUNX1T1 partenaires d'interaction

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. PKM2 (Montrer PKM Kits ELISA) as a novel target of RUNX1 (Montrer RUNX1 Kits ELISA)-ETO and is specifically downregulated in RUNX1 (Montrer RUNX1 Kits ELISA)-ETO positive AML (Montrer RUNX1 Kits ELISA) patients, indicating that PKM2 (Montrer PKM Kits ELISA) level might have a diagnostic potential in RUNX1 (Montrer RUNX1 Kits ELISA)-ETO associated AML (Montrer RUNX1 Kits ELISA).

  2. The specific association of ZBTB7A (Montrer ZBTB7A Kits ELISA) mutations with t(8;21) rearranged acute myeloid leukaemia points towards leukemogenic cooperativity between mutant ZBTB7A (Montrer ZBTB7A Kits ELISA) and the RUNX1 (Montrer RUNX1 Kits ELISA)/RUNX1T1 fusion protein has been reported.

  3. Data indicate miR (Montrer MLXIP Kits ELISA)-29b-1 as a regulator of the AML1 (Montrer RUNX1 Kits ELISA)-ETO protein (RUNX1 (Montrer RUNX1 Kits ELISA)-RUNX1T1), and that miR (Montrer MLXIP Kits ELISA)-29b-1 expression in t(8;21)-carrying leukemic cell lines partially rescues the leukemic phenotype.

  4. Altogether, these results revealed an unexpected and important epigenetic mini-circuit of AML1-ETO/THAP10/miR-383 in t(8;21) acute myeloid leukaemia, in which epigenetic suppression of THAP10 predicts a poor clinical outcome and represents a novel therapeutic target.

  5. RUNX1 (Montrer RUNX1 Kits ELISA)-RUNX1T1 transcript levels were measured in bone marrow samples collected from 208 patients at scheduled time points after transplantation. Over 90% of the 175 patients who were in continuous complete remission had a >/=3-log reduction in RUNX1 (Montrer RUNX1 Kits ELISA)-RUNX1T1 transcript levels from the time of diagnosis at each time point after transplantation and a >/=4-log reduction at >/=12 months.

  6. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (Montrer TFF1 Kits ELISA) are mechanistically connected to CEBPB (Montrer CEBPB Kits ELISA) and that cross-regulation between CEBPB (Montrer CEBPB Kits ELISA)-RUNX1t1-TFF1 (Montrer TFF1 Kits ELISA) plays an important role in gastric carcinogenesis.

  7. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  8. Leukaemogenesis by AML1-ETO requires enhanced C/D box snoRNA/RNP formation.

  9. Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1 (Montrer RUNX1 Kits ELISA)-175) of AML1 (Montrer RUNX1 Kits ELISA)-ETO is consistent with its contribution to the activity of full-length AML1 (Montrer RUNX1 Kits ELISA)-ETO and is mediated through its direct association with the DNA-binding domain

  10. the AML1 (Montrer RUNX1 Kits ELISA)-ETO fusion protein increases the expression of SIRT1 (Montrer SIRT1 Kits ELISA), possibly by binding to the promoter region of SIRT1 (Montrer SIRT1 Kits ELISA) to activate its transcription in t(8;21) AML (Montrer RUNX1 Kits ELISA).

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Results suggest that AML1 (Montrer RUNX1 Kits ELISA)/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  2. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (Montrer TFF1 Kits ELISA) are mechanistically connected to CEBPB (Montrer CEBPB Kits ELISA) and that cross-regulation between CEBPB (Montrer CEBPB Kits ELISA)-RUNX1t1-TFF1 (Montrer TFF1 Kits ELISA) plays an important role in gastric carcinogenesis.

  3. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  4. Leukaemogenesis by AML1-ETO requires enhanced C/D box snoRNA/RNP formation.

  5. Data show that RUNX1 (Montrer RUNX1 Kits ELISA)-ETO;c-Kit (Montrer KIT Kits ELISA)(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (Montrer BCL11A Kits ELISA) (AML (Montrer RUNX1 Kits ELISA)) in a fraction (51%) of reconstituted mice.

  6. Self-renewal induced by AML1 (Montrer RUNX1 Kits ELISA)/ETO in primary murine progenitors was inhibited when Aes (Montrer AES Kits ELISA) was decreased or absent.

  7. AML1 (Montrer RUNX1 Kits ELISA)-ETO synergizes with an ICSBP (Montrer IRF8 Kits ELISA) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  8. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (Montrer CEBPB Kits ELISA) and a novel regulator of early adipogenesis

  9. the loss of the molecular events of AML1 (Montrer RUNX1 Kits ELISA)-ETO C-terminal NCoR (Montrer NCOR1 Kits ELISA)/SMRT-interacting domain transforms AML1 (Montrer RUNX1 Kits ELISA)-ETO into a potent leukemogenic protein

  10. p15(Ink4b (Montrer CDKN2B Kits ELISA)) loss must be accompanied by additional oncogenic changes for RUNX1 (Montrer RUNX1 Kits ELISA)-ETO-associated AML (Montrer RUNX1 Kits ELISA) to develop

RUNX1T1 profil antigène

Antigen Summary

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1) anticorps
  • RUNX1 translocation partner 1 L homeolog (runx1t1.L) anticorps
  • RUNX1 translocation partner 1 (RUNX1T1) anticorps
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1) anticorps
  • RUNX1 translocation partner 1 (Runx1t1) anticorps
  • AML1T1 anticorps
  • Cbfa2t1 anticorps
  • Cbfa2t1h anticorps
  • CDR anticorps
  • ETO anticorps
  • MTG8 anticorps
  • si:ch211-232j17.1 anticorps
  • wu:fi14b07 anticorps
  • zgc:154044 anticorps
  • ZMYND2 anticorps

Protein level used designations for RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPECIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
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