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ERRgamma may exert oncogenic activity mainly associated with aggressiveness of EC by activating S100A4 transcription.
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S100A4 expression is induced by the TGF-beta pathway,.
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This meta-analysis showed that overexpression of S100A4 seems to be associated with tumor progression and poor prognosis of PC patients.
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clusterin promotes growth and invasion in renal cell carcinoma cells in vitro and in vivo through upregulation of S100A4
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miR-3189-3p mimics enhanced the effects of the S100A4 siRNA on the inhibition of gastric cancer cell proliferation and migration by targeting CFL2.
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Urine S100A4 shows the most promise as an lupus nephritis (LN) activity biomarker.
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S100A4 is up-regulated in cervical adenocarcinomas and squamous cell carcinomas.
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Network analysis of overlapping genes revealed the effects on tubulins (Tubb2a, Tubb3, Tubb4b), Nfe2l2, S100a4, Cd44, and Nfkb2, all of which are linked to TBI-relevant outcomes, including epileptogenesis and tissue repair
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Authors first provide experimental evidence suggesting that FAM107B was downregulated by S100A4 in gastric cancer MGC803 cells. And FAM107B at least partially mediates the biological effect of S100A4 in the cells.
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MiR-187 could interact with S100A4 3'-UTR.
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Both the calcium-binding ability and the C-terminal region of S100A4 are important for cancer initiatin cells to sustain their stemness properties and malignancy in head and neck cancers.
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Studied the role and expression of MIR296 in the metastasis and epithelial-mesenchymal transition of colorectal cancer. Found MIR296 inhibited migration and invasion of tumor cells, as well as suppressed S100A4 abundance in tumor cells.
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S100A4-expression was associated with poor outcome in early-stage breast cancer, but the low percentage of positive tumors and the modest survival differences imply that the clinical utility in selection of patients for adjuvant treatment is limited.
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The relative expression of S100A4 mRNA was higher when mod-SHEM was used, although significant differences were detected only when the expression levels were compared with those found in LPCs incubated with IOBA-FBS
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High S100A4 expression is associated with Mesenchymal Transition in Glioblastoma.
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our findings demonstrate that S100A4 is post-transcriptionally regulated by tumor suppressor microRNAs
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findings indicate that Idiopathic pulmonary fibrosis mesenchymal progenitor cells are intrinsically fibrogenic and that S100A4 confers mesenchymal progenitor cells with fibrogenicity.
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S100a4 is expressed in a limited number of stromal cells throughout the colon. S100A4 was mainly localised in the colorectal tumour-associated stroma, it was also detectable in a limited number of epithelial tumour cells.
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our results suggest the existence of evolutionarily conserved pathways used by S100A4 to promote metastatic dissemination
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miR-187-3p inhibits the migration/metastasis and epithelial mesenchymal transition in hepatocellular carcinoma by targeting S100A4 expression.