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SEC16A encodes a protein that forms part of the Sec16 complex.
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Human Polyclonal SEC16A Primary Antibody pour ICC, IF - ABIN151306
Abrami, Kunz, Iacovache, van der Goot: Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum. dans Proceedings of the National Academy of Sciences of the United States of America 2008
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Human Polyclonal SEC16A Primary Antibody pour ICC, IF - ABIN4352397
Willy, Young, Mosley, Gawrieh, Stevens, Masuoka, Wek: Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response. dans The Journal of biological chemistry 2017
Sec16A also stabilized the interacting ubiquitin ligase RNF152, which localizes to the lysosome and has structural similarity with RNF183
Mammalian endoplasmic reticulum exit sites are organized by TANGO1 (Montrer MIA3 Anticorps) acting as a scaffold, in cooperation with Sec16 for efficient secretion.
Results suggest that it is the presence of rare syntenic SEC16A and MAMDC4 deletions that increases susceptibility to axial spondyloarthritis in family members who carry the HLA-B*27 allele.
LRRK2 regulates the anterograde endoplasmic reticulum (ER)-Golgi transport through anchoring Sec16A at the endoplasmic reticulum exit sites (ERES).
Data show that knockdown of Sec16B (Montrer SEC16B Anticorps) but not Sec16A by RNAi affected the morphology of peroxisomes, inhibited the transport of Pex16 (Montrer PEX16 Anticorps) from the ER to peroxisomes, and suppressed expression of Pex3 (Montrer PEX3 Anticorps).
Sec16A remains associated with endoplasmic reticulum exit sites throughout mitosis.
Sar1 (Montrer IQGAP1 Anticorps)-GTP (Montrer AK3 Anticorps)-dependent assembly of Sec16 on the endoplasmic reticulum(ER) membrane forms an organized scaffold defining ER exit sites
Mammalian cells contain two distinct Sec16 homologues: a large protein Sec16L of 2154 aa and a smaller protein Sec16S (Montrer SEC16B Anticorps) of 1060 aa.
Results suggest that KIAA0310p, a mammalian homologue of yeast Sec16, builds up endoplasmic reticulum (ER) exit sites in cooperation with p125 (Montrer XPC Anticorps) and plays a role in membrane traffic from the ER.
This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
protein SEC16 homolog A
, protein transport protein Sec16A