SH2B Adaptor Protein 1 (SH2B1) Kits ELISA

SH2B1 encodes a member of the SH2-domain containing mediators family. De plus, nous expédions SH2B Adaptor Protein 1 Anticorps (71) et SH2B Adaptor Protein 1 Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SH2B1 25970 Q9NRF2
Anti-Souris SH2B1 SH2B1 20399 Q91ZM2
Anti-Rat SH2B1 SH2B1 89817 Q62985
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Plus Kits ELISA pour SH2B Adaptor Protein 1 partenaires d'interaction

Human SH2B Adaptor Protein 1 (SH2B1) interaction partners

  1. The increased expression of genes in leptin (JAK/STAT or AKT) signaling implies that the main mode of action for human SH2B1 mutations might affect leptin signaling rather than insulin signaling.

  2. The high-resolution structure of the SH2 domain of SH2B1 further reveals conformationally plastic protein loops that may contribute to the ability of the protein to recognize dissimilar ligands. Together, numerous hydrophobic and electrostatic interactions, in addition to backbone conformational flexibility, permit the recognition of diverse peptides by SH2B1.

  3. Copy number variations in SH2B1 gene is associated with distal syndromes with intellectual disability.

  4. Data reported that SH2B1 expression levels were significantly upregulated and positively associated with EMT markers and poor patient survival in lung adenocarcinoma (LADC) specimens. Further results reveal that SH2B1 has a major role in LADC progression and that SH2B1 is a critical activator of Wnt/beta-catenin signaling.

  5. This study is the first to show that neuronal SH2B1, a key protein in insulin signaling, may have a role in the accumulation of Abeta42 in an animal model of Alzheimer's Disease.

  6. Chromosome microarray analysis was performed on both twins and their parents. An identical 244 kb microdeletion on 16p11.2 including 9 Refseq genes, including SH2B1, was identified in the twins.

  7. SH2B1 fine-tunes global-local chromatin states.

  8. SH2B1 and RABEP1 genetic variants are associated with worsening of LDL and glucose parameters in patients treated with psychotropic drugs

  9. SH2B1 polymorphisms are associated with HbA1c, largely independent of BMI, in European American young adults.

  10. Results identified SH2B as a functional target of miR-361 which down-regulation suppresses lung cancer progression and metastasis through regulation of SH2B1.

  11. that SH2B1 is a key positive mediator of pathological cardiac hypertrophy

  12. Mutation analysis has demonstrated that variation in the SH2B1 gene is frequent in both lean and obese groups, with distinctive variations being present on either side of the weight spectrum.

  13. The rs7359397 (SH2B1) was associated with the body weight, body mass index, and truncal fat mass reduction.

  14. We report evidence that the 16p11.2 deletion may influence specific obesity-associated disinhibited eating behaviors

  15. 4 novel variants in SH2B1 were identified in individuals with obesity and insulin resistance.

  16. This study highlighted the importance of two candidate genes, SH2B1 and FAIM2, in the risk of overweight/obesity.

  17. SH2B1 can enhance neurite outgrowth and accelerate the maturation of human induced neurons under defined conditions.

  18. Data (from in excess of six genetic association studies) suggest that an SNP in SH2B1 (rs4788102) is not associated with abnormal glucose homeostasis in obese subjects of European ancestry. [META-ANALYSIS]

  19. Data show the synthetic effect of SNPs on the indices of adiposity and risk of obesity in Chinese girls, but failed to replicate the effect of five separate variants of SEC16B rs10913469, SH2B1 rs4788102, PCSK1 rs6235, KCTD15 rs29941 and BAT2 rs2844479.

  20. Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations.

Mouse (Murine) SH2B Adaptor Protein 1 (SH2B1) interaction partners

  1. The increased expression of genes in leptin (JAK/STAT or AKT) signaling implies that the main mode of action for SH2B1 mutations might affect leptin signaling rather than insulin signaling.

  2. Brain-specific Sh2b1 knockout (KO) mice exhibited brain growth retardation and reactive aggression.

  3. data identify SH2B1 as a major regulator of IRS2 stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2, and identify 4E-BP2 as a major regulator of proliferation and survival of beta-cells.

  4. that SH2B1 is a key positive mediator of pathological cardiac hypertrophy

  5. SH2B1 in pancreatic beta-cells promotes insulin synthesis and secretion at least in part by enhancing activation of JAK2 and/or Pdx1 pathways in response to hormonal and nutritional signals.

  6. hepatic SH2B1 is not required for the maintenance of normal insulin sensitivity and glucose metabolism; however, it regulates liver triacylglycerol synthesis, lipolysis, and VLDL secretion.

  7. These data indicate that SH2B1 in beta-cells is an important prosurvival and proproliferative protein and promotes compensatory beta-cell expansion in the insulin-resistant state and in response to beta-cell stress.

  8. Results suggest that SH2B1beta enhances GH-stimulated macrophage motility via mechanisms involving phosphorylation of SH2B1beta on tyrosines 439 and 494 and movement of SH2B1beta out of the plasma membran.

  9. SH2B1 is responsive to erythropoietin stimulation and becomes phosphorylated

  10. serves as a focal adhesion protein that regulates focal adhesion size and number

  11. Leptin-stimulated activation of hypothalamic JAK2 and phosphorylation of hyphothalamic IRS2 were significantly impaired in SH2B1(-/-) mice.

  12. Mutations in the SH2 domain of SH2B1 may increase the susceptibility to obesity and type 2 diabetes in a dominant-negative manner.

  13. Genetic deletion of SH2B1 also resulted in growth retardation, obesity, and type 2 diabetes in mice; surprisingly, life span and oxidative resistance were reduced in SH2B1 null mice.

  14. These results suggest that SH2-Bbeta regulation of Akt partly participates in the NGF-mediated development of allergic airway challenge.

  15. These results suggest that 1) SH2-B beta specifically activates JAK2, 2) APS negatively regulates both JAK2 and JAK1, and 3) both SH2-B beta and APS may serve as adapter proteins for all three JAKs independent of any role they have in JAK activity.

  16. Lnk, SH2-B, and APS have roles in mast cell development, growth, and functions

  17. Data suggest that SH2-B is a physiological enhancer of insulin receptor activation and is required for maintaining normal insulin sensitivity and glucose homeostasis during aging.

  18. regulates the activity of a variety of transporters under normal and pathological conditions

  19. Data suggest that SH2-B is an endogenous enhancer of leptin sensitivity and required for maintaining normal energy metabolism and body weight in mice.

  20. SH2-B, but not APS, is a key positive regulator of energy and glucose metabolism in mice

SH2B Adaptor Protein 1 (SH2B1) profil antigène

Antigen Summary

This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with SH2B1

  • SH2B adaptor protein 1 (SH2B1) anticorps
  • SH2B adaptor protein 1 (sh2b1) anticorps
  • SH2B adaptor protein 1 (Sh2b1) anticorps
  • AI425885 anticorps
  • C530001K22Rik anticorps
  • Irip anticorps
  • mKIAA1299 anticorps
  • PSM anticorps
  • Sh2-b anticorps
  • SH2-Bb anticorps
  • Sh2b anticorps
  • SH2B3 anticorps
  • Sh2bpsm1 anticorps
  • zgc:158474 anticorps

Protein level used designations for SH2B1

SH2B adapter protein 1 , SH2B adaptor protein 1 , SH2B adapter protein 1-like , SH2 domain-containing protein 1B , SH2 domain-containing putative adapter SH2-B , SH2-B signaling protein , pro-rich, PH and SH2 domain-containing signaling mediator , PSM , SH2-B PH domain containing signaling mediator 1 , SH2-B PH domain-containing signaling mediator 1 , fceRI gamma-chain-interacting protein SH2-B

506066 Bos taurus
558152 Danio rerio
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100385268 Callithrix jacchus
100470297 Ailuropoda melanoleuca
100587926 Nomascus leucogenys
25970 Homo sapiens
20399 Mus musculus
89817 Rattus norvegicus
612792 Canis lupus familiaris
100516788 Sus scrofa
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