SIX Homeobox 6 (SIX6) Kits ELISA

The protein encoded by SIX6 is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. De plus, nous expédions SIX Homeobox 6 Anticorps (45) et SIX Homeobox 6 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SIX6 20476 Q9QZ28
SIX6 4990 O95475
SIX6 314221  
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  96 Tests 2 to 3 Days

Plus Kits ELISA pour SIX Homeobox 6 partenaires d'interaction

Mouse (Murine) SIX Homeobox 6 (SIX6) interaction partners

  1. Six3 and Six6 together directly or indirectly suppress Wnt/beta-catenin signaling but promote retinogenic factors for the maintenance of multipotent neuroretinal progenitors.

  2. Six6 plays distinct roles in maintaining fertility in the GnRH neuron vs in the migratory environment of the GnRH neuron by maintaining expression of GnRH and survival of GnRH neurons, respectively.

  3. SIX3 and SIX6 play distinct but compensatory roles in regulating transcription of gonadotrope-specific genes as gonadotrope cells differentiate.

  4. Six6-null mice display abnormal patterns of circadian behavior.

  5. SoxB1 transcription factors are direct activators of Six6 expression in the ventral forebrain

  6. Six6 plays an important role in the regulation of GnRH expression and hypothalamic control of fertility.

  7. in association with Dach corepressors, regulates proliferation of retinal and pituitary precursor cells by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter

  8. Six 3 and Six 6 are differentially required during forebrain development; gene expression in brain

  9. Results show that Lhx2 and Pax6 transcription factors operate in a concerted manner during retinal development to promote transcriptional activation of the Six6 homeobox-gene in primitive and mature retinal progenitors.

Xenopus laevis SIX Homeobox 6 (SIX6) interaction partners

  1. Data show that both six6.L and six6.S expression was restricted to the retina and optic stalk of tailbud embryos.

  2. 2 evolutionary conserved regions 5' and a third 3' to the six6 coding region were identified. The conserved 3' region was necessary and sufficient for eye field and optic vesicle expression. Both conserved enhancer regions located 5' of the coding sequence were required for normal optic cup and mature retinal expression.

Human SIX Homeobox 6 (SIX6) interaction partners

  1. This meta-analysis confirmed the association of rs10483727 and rs33912345 in SIX1-SIX6 with primary open-angle glaucoma (POAG).

  2. The protein-coding SIX6 variant rs33912345, previously associated with primary open-angle glaucoma (POAG), has a functional effect on glaucoma-associated optic nerve head traits in Europeans.

  3. The BMP4- 152AA genotype might play role in the causation of congenital cataract, whereas BMP4-SIX6 V-N haplotype might play a protective role toward the development of congenital cataract and microphthalmia.

  4. In conclusion, this study confirmed the association between two genome wide association study single nucleotide polymorphisms in SIX6 (rs33912345 and rs10483727) and primary open-angle glaucoma (POAG).

  5. Mutation in SIX6 gene is associated with primary open angle glaucoma.

  6. we confirmed that rs33912345 and rs10483727-the only known cpRNFLT susceptibility SNPs-showed the strongest association with cpRNFLT of those within the SIX1/SIX6 locus.

  7. The results suggest that SIX6 influences different stages of RGC differentiation and their survival; therefore, alteration in SIX6 function due to the risk allele may lead to cellular and molecular abnormalities.

  8. We replicated the association of SNP rs10483727 in the SIX1/SIX6 locus with POAG in a Saudi cohort, suggesting its role in increasing susceptibility to Primary Open Angle Glaucoma .

  9. Among 8 SNPs in 3 loci that showed at least nominal association (P < 5.00E-02) in the primary cohort, a representative SNP for each loci (rs2157719 for CDKN2B-AS1, rs33912345 for SIX6, and rs9913911 for GAS7) were selected

  10. elevated expressions of SIX2, SIX4, and SIX6 predicted poor overall survival (OS) in NSCLC and poor relapse-free survival (RFS) in lung adenocarcinoma

  11. study replicated the association of POAG with two SNPs at the SIX1-SIX6 locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG in patients aged above 40 years

  12. Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26.

  13. Single nucleotide polymorphism in SIX6 gene is associated with primary open angle glaucoma.

  14. SIX6 and/or intraocular pressure promotes primary open-angle glaucoma by directly increasing p16INK4a expression.

  15. we report a homozygous missense mutation of SIX6 associated with a unique eye phenotype characterized by optic disc anomalies, macular atrophy, and coloboma of the iris and chorioretina.

  16. Nonglaucomatous individuals with the SIX6 missense variant have reduced RNFL thickness in regions known to be particularly affected in those with glaucoma.

  17. Our results, in combination with previous SIX6 work, lead us to hypothesize that SIX6 risk variants disrupt the development of the neural retina, leading to a reduced number of retinal ganglion cells.

  18. Our findings in humans and zebrafish suggest a functional involvement of six6b in early eye development, and open new insights into the genetic architecture of POAG.

  19. No evidence was found that SIX6 mutations underlie human congenital structural eye malformations.

  20. Six6 and Six2 differ in their DNA-binding mechanisms and in the consequences of their interaction with protein tyrosine phosphatase Eyes Absent in Six2/6-DNA-binding ability.

Cow (Bovine) SIX Homeobox 6 (SIX6) interaction partners

  1. a new helix in the C-terminal domain of the mutated bovine SIX6 protein was revealed, which possibly affects pituitary development and hormone secretion

SIX Homeobox 6 (SIX6) profil antigène

Antigen Summary

The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2).

Gene names and symbols associated with SIX Homeobox 6 (SIX6) Kits ELISA

  • sine oculis-related homeobox 6 (Six6) anticorps
  • SIX homeobox 6a (six6a) anticorps
  • SIX homeobox 6 L homeolog (six6.L) anticorps
  • SIX homeobox 6 (SIX6) anticorps
  • SIX homeobox 6 (Six6) anticorps
  • MCOPCT2 anticorps
  • MGC63871 anticorps
  • OPTX2 anticorps
  • Six6 anticorps
  • Six6.1 anticorps
  • Six6.2 anticorps
  • Six9 anticorps
  • XOptx2 anticorps
  • xSix6 anticorps
  • zgc:63871 anticorps

Protein level used designations for SIX Homeobox 6 (SIX6) Kits ELISA

homeobox protein SIX6 , optic homeobox 2 , sine oculis homeobox homolog 6 , sine oculis-related homeobox 6 homolog , sine oculis-related homeobox 6a , homeobox protein Optx2 , homeodomain protein OPTX2

20476 Mus musculus
394080 Danio rerio
398128 Xenopus laevis
395843 Gallus gallus
4990 Homo sapiens
490718 Canis lupus familiaris
539749 Bos taurus
314221 Rattus norvegicus
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