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This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. De plus, nous expédions SRGAP2 Anticorps (33) et SRGAP2 Kits (3) et beaucoup plus de produits pour cette protéine.
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Results show that in high-grade, stage II osteosarcoma samples, expression of SRGAP2 was substantially reduced or absent in over half of the samples. Functional analysis provides further evidence that SRGAP2 may have a role as a suppressor of metastases in osteosarcoma.
SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration.
The extended F-BAR (F-BARx) domain of SRGAP2 generates membrane protrusions when expressed in COS-7 cells, while most F-BARs induce the opposite effect: membrane invaginations. As a first step to understand this discrepancy, the F-BARx domain of SRGAP2 was isolated and crystallized after co-expression with the carboxy domains of the protein. Diffraction data were reprocessed with a high-resolution cutoff of 2.2 A.
human-specific duplication of SRGAP2 might have contributed to the emergence of unique traits of human neurons while preserving the excitation/inhibition balance
This study illustrated that the role of SRGAP2 protein and its human-specific paralogs in human brain development and evolution.
interlocus gene conversions in SRGAP2
SRGAP2 has been highly conserved over mammalian evolution, and human is the only lineage wherein gene duplications have occurred. Our analysis indicates that the duplications spread across 80 Mbp of chromosome 1 at a time corresponding to the transition from Australopithecus to Homo.
Results uncover a new function for ancestral SRGAP2 in promoting dendritic spine maturation and indicate that expression of a human-specific paralog of SRGAP2 in mouse pyramidal neurons extends the phase of spine development and leads to an increased density of longer spines in vivo, a feature characterizing pyramidal neurons in the human neocortex
after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics.
srGAP2 arginine methylation plays important roles in cell spreading and cell migration through influencing membrane protrusion.
FNBP2 gene was linked to IKBKE and NORE1 genes on human chromosome 1q32.1. FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma.
Results show that the effects of Srgap2 expression modulation in the murine OS cell lines support the hypothesis that SRGAP2 may have a role as a suppressor of metastases in osteosarcoma.
The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.
Data show that srGAP2 is expressed in zones of neuronal differentiation in many different tissues of the central nervous system.
Study reports that srGAP2 negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains.
SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration. Knockdown of SRGAP2a, a SRGAP2 ortholog in zebrafish, recapitulates podocyte foot process effacement.
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogous loci on human chromosome 1, resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.
SLIT-ROBO Rho GTPase-activating protein 2
, formin binding protein 2
, formin-binding protein 2
, rho GTPase-activating protein 34
, formin-binding protein 27
, LOW QUALITY PROTEIN: SLIT-ROBO Rho GTPase-activating protein 2
, SLIT-ROBO Rho GTPase activating protein 2a