SLIT-ROBO rho GTPase Activating Protein 2 Protéines (SRGAP2)

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. De plus, nous expédions SRGAP2 Anticorps (30) et SRGAP2 Kits (3) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SRGAP2 23380 O75044
SRGAP2 14270 Q91Z67
Rat SRGAP2 SRGAP2 360840 D4A208;
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$932.80
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SRGAP2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) partenaires d'interaction

Human SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) interaction partners

  1. These results indicated that the SRGAP2 SNPs and their haplotypes were associated with serum lipid levels. Their haplotypes can explain much more serum lipid variation than any single SNP alone, especially for serum TC, HDL-C and ApoA1 levels.

  2. Results show that in high-grade, stage II osteosarcoma samples, expression of SRGAP2 was substantially reduced or absent in over half of the samples. Functional analysis provides further evidence that SRGAP2 may have a role as a suppressor of metastases in osteosarcoma.

  3. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration.

  4. The extended F-BAR (F-BARx) domain of SRGAP2 generates membrane protrusions when expressed in COS-7 cells, while most F-BARs induce the opposite effect: membrane invaginations. As a first step to understand this discrepancy, the F-BARx domain of SRGAP2 was isolated and crystallized after co-expression with the carboxy domains of the protein. Diffraction data were reprocessed with a high-resolution cutoff of 2.2 A.

  5. human-specific duplication of SRGAP2 might have contributed to the emergence of unique traits of human neurons while preserving the excitation/inhibition balance

  6. This study illustrated that the role of SRGAP2 protein and its human-specific paralogs in human brain development and evolution.

  7. interlocus gene conversions in SRGAP2

  8. SRGAP2 has been highly conserved over mammalian evolution, and human is the only lineage wherein gene duplications have occurred. Our analysis indicates that the duplications spread across 80 Mbp of chromosome 1 at a time corresponding to the transition from Australopithecus to Homo.

  9. Results uncover a new function for ancestral SRGAP2 in promoting dendritic spine maturation and indicate that expression of a human-specific paralog of SRGAP2 in mouse pyramidal neurons extends the phase of spine development and leads to an increased density of longer spines in vivo, a feature characterizing pyramidal neurons in the human neocortex

  10. after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics.

  11. srGAP2 arginine methylation plays important roles in cell spreading and cell migration through influencing membrane protrusion.

  12. FNBP2 gene was linked to IKBKE and NORE1 genes on human chromosome 1q32.1. FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma.

Mouse (Murine) SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) interaction partners

  1. Results show that the effects of Srgap2 expression modulation in the murine OS cell lines support the hypothesis that SRGAP2 may have a role as a suppressor of metastases in osteosarcoma.

  2. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration.

  3. The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.

  4. Data show that srGAP2 is expressed in zones of neuronal differentiation in many different tissues of the central nervous system.

  5. Study reports that srGAP2 negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains.

Zebrafish SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) interaction partners

  1. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration. Knockdown of SRGAP2a, a SRGAP2 ortholog in zebrafish, recapitulates podocyte foot process effacement.

Profil protéine SRGAP2

Profil protéine

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogous loci on human chromosome 1, resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.

Gene names and symbols associated with SRGAP2

  • SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2)
  • SLIT-ROBO Rho GTPase activating protein 2 (Srgap2)
  • SLIT-ROBO Rho GTPase activating protein 2 (srgap2)
  • 9930124L22Rik Protéine
  • AI448945 Protéine
  • ARHGAP34 Protéine
  • FBP2 Protéine
  • Fnbp2 Protéine
  • RGD1566016 Protéine
  • srGAP2 Protéine
  • srgap2a Protéine
  • srGAP3 Protéine
  • wu:fb47h12 Protéine
  • zgc:136814 Protéine

Protein level used designations for SRGAP2

SLIT-ROBO Rho GTPase-activating protein 2 , formin binding protein 2 , formin-binding protein 2 , rho GTPase-activating protein 34 , FBP-27 , formin-binding protein 27 , LOW QUALITY PROTEIN: SLIT-ROBO Rho GTPase-activating protein 2 , SLIT-ROBO Rho GTPase activating protein 2a

GENE ID SPECIES
23380 Homo sapiens
14270 Mus musculus
360840 Rattus norvegicus
100716665 Cavia porcellus
556198 Danio rerio
478949 Canis lupus familiaris
519843 Bos taurus
100050923 Equus caballus
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