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SCIMP encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. De plus, nous expédions SCIMP Anticorps (36) et beaucoup plus de produits pour cette protéine.
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results suggest that SCIMP is involved in signal transduction after MHC-II stimulation and therefore serves as a regulator of antigen presentation and other APC functions.
In macrophages, SCIMP is constitutively associated with the Lyn tyrosine kinase, is required for tyrosine phosphorylation of TLR4, and facilitates TLR-inducible production of the IL-6 and IL-12p40.
SCIMP is strongly phosphorylated after Dectin-1 stimulation and that it participates in signal transduction downstream of this important pattern recognition receptor.
This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene.
, SLP adapter and CSK-interacting membrane protein
, SLP65/SLP76, Csk-interacting membrane protein
, transmembrane protein C17orf87
, transmembrane protein C17orf87 homolog