SMURF2 Kits ELISA

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Qualité de données
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Type
  • 4
    Kit
Antigène
  • 4
Réactivité
  • 2
  • 1
  • 1
Application
  • 4
Type de méthode
  • 2
Analytical Method
  • 2
Méthode de détection
  • 4
Plate
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Sample
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4 Produits
Pre-coated, Type d'échantillon: Cell Lysate, Tissue Homogenate
ReactivitéRat (Rattus)
Méthode de détectionColorimetric, Sandwich ELISA
Portée de detection0.78 ng/mL - 50 ng/mL
Détails de la commande Cat. No. ABIN4948032
$880.00
96 tests
Plus shipping costs $45.00
Envoi sous 13 à 16 jours ouvrables
ReactivitéHumain
Méthode de détectionColorimetric,
Détails de la commande Cat. No. ABIN1131327
$875.60
96 tests
Plus shipping costs $45.00
Envoi sous 15 à 18 jours ouvrables
ReactivitéSouris
Méthode de détectionColorimetric,
Détails de la commande Cat. No. ABIN1131328
$875.60
96 tests
Plus shipping costs $45.00
Envoi sous 15 à 18 jours ouvrables
Pre-coated, Type d'échantillon: Cell Lysate, Tissue Homogenate
ReactivitéRat (Rattus)
Méthode de détectionColorimetric, Sandwich ELISA
Portée de detection0.781 ng/mL - 50 ng/mL
Détails de la commande Cat. No. ABIN5658835
$1,136.15
96 tests
Plus shipping costs $45.00
Envoi sous 8 à 12 jours ouvrables
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SMURF2 profil antigène

Profil protéine

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).

Gene names and symbols associated with SMURF2

  • SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) anticorps
  • SMAD specific E3 ubiquitin protein ligase 2 (smurf2) anticorps
  • SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) anticorps
  • SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S) anticorps
  • 2810411E22Rik anticorps
  • AI558114 anticorps
  • AI649275 anticorps
  • RGD1310067 anticorps
  • SMURF2 anticorps
  • wu:fb82a11 anticorps
  • wu:fc41c02 anticorps

Protein level used designations for SMURF2

SMAD specific E3 ubiquitin protein ligase 2 , E3 ubiquitin-protein ligase SMURF2-like , e3 ubiquitin-protein ligase SMURF2-like , E3 ubiquitin ligase SMURF2 , E3 ubiquitin-protein ligase SMURF2 , SMAD ubiquitination regulatory factor 2 , SMAD-specific E3 ubiquitin-protein ligase 2 , hSMURF2 , E3 ubiquitin ligase Smurf2

GENE ID SPECIES
100064082 Equus caballus
100230714 Taeniopygia guttata
454761 Pan troglodytes
480470 Canis lupus familiaris
717902 Macaca mulatta
100038194 Xenopus (Silurana) tropicalis
100358121 Oryctolagus cuniculus
100374187 Saccoglossus kowalevskii
100386392 Callithrix jacchus
100459970 Pongo abelii
100473715 Ailuropoda melanoleuca
100603634 Nomascus leucogenys
64750 Homo sapiens
66313 Mus musculus
303614 Rattus norvegicus
427809 Gallus gallus
540826 Bos taurus
398372 Xenopus laevis
563633 Danio rerio