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The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription.
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Human Polyclonal SP110 Primary Antibody pour IHC, ELISA - ABIN1002686
Bloch, Nakajima, Gulick, Chiche, Orth, de La Monte, Bloch: Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. dans Molecular and cellular biology 2000
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Human Polyclonal SP110 Primary Antibody pour ELISA, WB - ABIN1002687
Pan, Yan, Rojas, Shebzukhov, Zhou, Kobzik, Higgins, Daly, Bloom, Kramnik: Ipr1 gene mediates innate immunity to tuberculosis. dans Nature 2005
Show all 3 Pubmed References
SP110 as a novel susceptibility gene for Mycobacterium avium subspecies paratuberculosis infection in cattle.
Novel splice variants of SP110 in the horse have an activation effect on macrophages.
SP110 polymorphism is associated with tuberculosis.
Data suggest that Sp110 is sumoylated, de-sumoylated, and then released from the promyelocytic leukemia (Montrer PML Anticorps) nuclear bodies in hepatocytes infected with HBV (hepatitis B virus); Sp110 differentially regulates several direct target genes of HBx, a viral co-factor; these mechanisms may be involved in evasion of host immune response by HBV. (Sp110 = Speckled 110 kDa; HBx = hepatitis B virus protein X)
Using mouse models and genetic characteristics of human patients the role of SP110b was studied to determine its role in controlling host immunity and susceptibility to TB by modulating nuclear factor-kappaB (NF-kappaB (Montrer NFKB1 Anticorps)) activity resulting in down regulation of TNF-alpha (Montrer TNF Anticorps) production and upregulation of NF-kappaB (Montrer NFKB1 Anticorps)-induced antipoptotic gene expression suppressing IFN-gamma (Montrer IFNG Anticorps)-mediated monocyte and/or macrophage cell death.
The results indicated that both the heterozygous genotype GC and homozygous genotype CC in rs3809849 in MYBBP1A (Montrer MYBBP1A Anticorps) had significant effects on the risk of pulmonary tuberculosis, and heterozygous genotype CT in rs9061 in SP110 also had similar effects.
Results show that SP110 variants were associated with increased susceptibility to both pulmonary and extra-pulmonary tuberculosis in the Vietnamese patients. Those variants may influence macrophage signaling responses and apoptosis during the infection.
Study suggests that a combination of SP110 and MYBBP1A gene polymorphisms may serve as a novel marker for identifying the risk of developing TB in the Chinese Han population.
Several SNPs in Sp110 are risk factors for susceptibility to tuberculosis in Chongqing Han People.
In a pooled analysis of 10,624 cases of tuberculosis, there was not a significant association between polymorphisms in the SP110 gene and disease susceptibility. [Meta-analysis]
Genotyped 20 SNPs located in the SP110 gene, for the first time in a South East Asian cohort from Indonesia.Our study did not reveal any statistically significant associations between SP110 SNPs and pulmonary TB.
a range of mutations in SP110 that cause decreased SP110 protein levels and impaired late B-cell differentiation cause veno-occlusive disease with immunodeficiency syndrome.
mechanistic studies revealed that an arginine/lysine-rich element within the DNA-binding domain (SAND domain) is critical for Ipr1 binding to the importin protein receptor NPI-1 (Montrer KPNA1 Anticorps), demonstrating that this element plays an essential role in mediating the nuclear localization of Ipr1 protein
These findings not only reveal the transcriptional basis of Sp110-mediated macrophage resistance to Mtb (Montrer NCAPG2 Anticorps), but also suggest potential regulatory roles for Sp110 related to inflammatory responses, miRNA profiles, and the intracellular growth of Mtb (Montrer NCAPG2 Anticorps).
Ipr1 might be involved in apoptosis pathway via MYBBP1A (Montrer MYBBP1A Anticorps).
identification and analysis of the genes Sp100 (Montrer SP100 Anticorps), Csprs, and Ifi75 in two members of the genus Mus (Montrer TRPV6 Anticorps), M. musculus and M. caroli
data indicate that the Ipr1 gene product might have a previously undocumented function in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death and pathogenesis
The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.
SP110 nuclear body protein
, sp110 nuclear body protein-like
, interferon-induced protein 41, 30kD
, interferon-induced protein 41/75
, interferon-induced protein 75, 52kD
, phosphoprotein 41
, phosphoprotein 75
, sp110 nuclear body protein
, speckled 110 kDa
, transcriptional coactivator Sp110
, intracellular pathogen resistance 1
, intracellular pathogen resistance protein 1