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Steroid receptor RNA activator (SRA, or SRA1\; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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LRPPRC (Montrer LRPPRC Anticorps) displays a broad and strong RNA binding capacity in vitro in contrast to SLIRP that associates only weakly with RNA.
Although SLIRP is not involved in mediating bcl-2 (Montrer BCL2 Anticorps) ability to protect from apoptosis and oxidative damage, bcl-2 (Montrer BCL2 Anticorps) binds and stabilizes SLIRP protein and regulates mitochondrial mRNA levels. The BH4 domain of bcl-2 (Montrer BCL2 Anticorps) has a role in maintaining this binding.
The LRPPRC (Montrer LRPPRC Anticorps)/SLIRP complex suppressed 3' exonucleolytic mRNA degradation mediated by PNPase (Montrer PNPT1 Anticorps) and SUV3 (Montrer SUPV3L1 Anticorps).
LRPPRC exists in a high-molecular-weight complex, and it coimmunoprecipitates with SLIRP, a stem-loop RNA-binding protein.
Our data demonstrate that SLIRP modulates NR transactivation, suggest it may regulate mitochondrial function, and provide mechanistic insight into interactions between SRA (Montrer SRA1 Anticorps), SLIRP, SRC-1 (Montrer SRC Anticorps), and NCoR (Montrer NCOR1 Anticorps).
SLIRP plays an essential role in maintaining mitochondrial-localized mRNA transcripts that encode OxPhos protein subunits.
both LRPPRC (Montrer LRPPRC Anticorps) and SLIRP are required for maintaining mt-mRNA steady-state levels independent of their roles in stabilizing the other partner of the LRPPRC (Montrer LRPPRC Anticorps)-SLIRP complex.
SLIRP regulates male fertility, wherein its loss results in asthenozoospermia associated with compromised sperm structure and mitochondrial morphology.
Steroid receptor RNA activator (SRA, or SRA1\; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006
SRA stem-loop-interacting RNA-binding protein, mitochondrial
, chromosome 14 open reading frame 156