SRY (Sex Determining Region Y)-Box 3 (SOX3) Kits ELISA

SOX3 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. De plus, nous expédions SOX3 Anticorps (73) et SOX3 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SOX3 6658 P41225
SOX3 20675  
SOX3 679158  
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Top SOX3 Kits ELISA sur

Showing 10 out of 18 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 46.875 pg/mL 78.125-5000 pg/mL Typical standard curve 96 Tests 12 to 14 Days
Souris 0.094 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests 12 to 14 Days
Lapin 0.1 ng/mL 1.0-25 ng/mL   96 Tests 15 to 18 Days
Cobaye 0.1 ng/mL 1.0-25 ng/mL   96 Tests 15 to 18 Days
Rat 0.1 ng/mL 1.0-25 ng/mL   96 Tests 15 to 18 Days
Porc 46.875 pg/mL 78.125-5000 pg/mL   96 Tests 12 to 14 Days
Poulet 2.344 pg/mL 3.906-250 pg/mL   96 Tests 12 to 14 Days
Singe 0.1 ng/mL 1.0-25 ng/mL   96 Tests 15 to 18 Days
Chien 0.1 ng/mL 1.0-25 ng/mL   96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days

Plus Kits ELISA pour SOX3 partenaires d'interaction

Human SRY (Sex Determining Region Y)-Box 3 (SOX3) interaction partners

  1. SOX3 can promote the malignant behavior of glioblastoma cells.

  2. This is the first study to report that the rare SOX3 missense variant associated with hypopituitarism possibly due to increased activation of SOX3 target genes and disregulation of beta-catenin target genes.

  3. Pathogenic missense mutation in SOX3 gene is associated with intellectual disability, microphthalmia, coloboma, hypopituitarism, facial dysmorphology and dental anomalies, including microcephaly, retrognathia and a solitary median maxillary central incisor amongst other features.

  4. our data indicate that SOX3 may serve as an oncogene in osteosarcoma

  5. deletion of the SOX3 gene may have a role in intellectual disability with hemophilia B

  6. Results show that SOX3 is upregulated in human osteosarcoma (OS) tissues and provide evidence that SOX3 promotes migration, invasiveness, and EMT in OS cells via transcriptional activation of Snail1 expression.

  7. we provide a first map of the epigenetic landscape of SOX3 in pluripotent cells and during the early phases of neural differentiation. We found SOX3 gene to be non methylated from undifferentiated NT2/D1 to cells committed towards neural lineage.

  8. These findings demonstrate the novel mechanism by which Sox3 contributes to endometrial cancer stem cell invasion and suggest that repression of Sox3 by microRNA-194 may have therapeutic potential to suppress endometrial carcinoma metastasis. The cancer stem cell marker, CD133, might be the surface marker of endometrial cancer stem cell.

  9. Data indicate that SRY-box 3 transcription factor SOX-3 targets Src kinase in epithelial ovarian cancer (EOC) cells.

  10. SOX3 overdosage permits normal sex development in 46,XX individuals with random X inactivation.

  11. Translocations interrupting this region may also affect the gonadal development, possibly depending on the chromatin context of the recipient chromosome. SOX3 duplications may substitute SRY in some XX subjects

  12. Screening for SOX3 should be advised not only for hypopituitary patients with an ectopic posterior pituitary, but also for those with a structurally normal pituitary

  13. Our study provides additional evidence that deletion in polyalanine tracts of SOX3 is associated with hypopituitarism

  14. SOX3 duplication is a genetic cause for XH but has incomplete penetrance. Moreover, increased SOX3 levels may be a risk factor for NTD and potentially other clinical characteristics.

  15. the results point at CREB as a positive regulator of SOX3 gene transcription in NT2/D1 cells, while its contribution to RA induction of SOX3 promoter is not prominent.

  16. Overexpression of Sox3 is associated with esophageal squamous cell carcinoma.

  17. Data indicate that HESX1, LHX4 and SOX3 polymorphisms may be associated with pituitary stalk interruption syndrome (PSIS).

  18. Results indicate positive expression of SOX2, SOX3, PAX6, OCT3/4, and NANOG in the CD105+ and CD105(-) cell subpopulations.

  19. TGIF (TG-interacting factor) is an additional TALE superfamily member involved in the regulation of human SOX3 gene expression

  20. these results strongly support the pathogenicity of the identified insertions near SOX3 and establish X-linked congenital hypertrichosis syndrome as a genomic disorder.

Mouse (Murine) SRY (Sex Determining Region Y)-Box 3 (SOX3) interaction partners

  1. Temporal onset of astrocyte gene expression is coordinated by SOX3-mediated repression of SOX9 activation.

  2. Optimal SOXB1 levels are critical for each pluripotent state and for cell fate decisions during exit from naive pluripotency.

  3. CRISPR/Cas9-assisted gene swap provides strong evidence that SOX2 and SOX3 proteins are functionally equivalent in developing brain and testes.

  4. Sox3 null mice exhibit a ventral extension of the anterior pituitary that penetrates, and generates a mass beneath, the sphenoid bone

  5. These data define Dbx1 as a direct SOX3 target gene.

  6. Sox2 and Sox3 play a role in central nervous system glia and provide mechanistic insights into their function during differentiation processes.

  7. findings show SOX3 expression is maintained throughout telencephalic neurogenesis and is restricted to progenitor cells with neuroepithelial and radial glial morphologies; it is expressed within adult neurogenic regions; expression within the developing hypothalamus is upregulated in developing neurons and is maintained in a subset of differentiated hypoththalamic cells

  8. Subcommissural organ function is essential for the prevention of hydrocephalus and overexpression of Sox3 in the dorsal midline alters progenitor cell differentiation in a dose-dependent manner.

  9. It was shown that Sox2 and Sox3 are dose-dependent regulators of sonic hedgehog transcription that directly bind and activate a long-range Shh forebrain enhancer.

  10. In neural precursor cells , Sox3 binds genes that are later bound and activated by Sox11 in differentiating neurons (Sox2)

  11. The results indicate that Sox3 functions in an intrinsic manner to promote differentiation of spermatogonia in prepubertal mice but it is not required for ongoing spermatogenesis in adults.

  12. in a transgenic line, Sox3 was ectopically expressed in the bipotential gonad and this led to frequent complete XX male sex reversal

  13. Sox3 is not required for gonadal determination but is important for normal oocyte development and male testis differentiation and gametogenesis.

  14. sox3 is required in the presumptive hypothalamus and infundibulum for correct morphgegesis of Rathke's pouch and later for correct function of the ypothalamic-pituitary locus

  15. Sox3 is expressed in spermatogonia and is required for spermatogenesis through a pathway that involves Ngn3.

  16. there is a requirement for the HMG box factor SOX3 during the earliest stage of pharyngeal development: the formation of the pharyngeal pouches that segment the pharyngeal region by individualising each arch

Zebrafish SRY (Sex Determining Region Y)-Box 3 (SOX3) interaction partners

  1. these findings show that sox2 and sox3 are together required for proper otic induction, but the level of expression must be tightly regulated to avoid suppression of differentiation and maintenance of pluripotency.

  2. these data show that sox2 and sox3 exhibit intrinsic differences in promoting sensory vs. neural competence, but at high levels these factors can mimic each other to enhance both states. Regional cofactors like pax2a and fgf8 also modify sox2/3 functions.

  3. significant decreases in sox3 (up to 3-fold) expression following chilling. Significant increases in expression of sox3 (up to 33-fold) during warming of chilled zebrafish embyos.

  4. Knockdown of fgf24 or sox3 causes severe epibranchial deficiencies but has little effect on otic development

  5. Knockdown of the four B1 sox genes sox2/3/19a/19b resulted in severe developmental abnormalities.

  6. The pro-neural effects of Sox3 can compensate for inhibition of fibroblast growth factor (Fgf) signalling in inducing neural tissue but it is not sufficient to maintain neural fate, suggesting the presence of Sox3-independent roles of Fgf at later stages.

Xenopus laevis SRY (Sex Determining Region Y)-Box 3 (SOX3) interaction partners

  1. Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.

  2. XSeb4R protein bound specifically to the 3'UTR of Sox3 mRNA. XSeb4R gain-of-function in ectodermal explants revealed increased stability of the maternal Sox3 transcripts, associated with a robust Sox3 protein production.

  3. knockdown of Oct91 inhibits neural induction driven by either Sox2 or Sox3.

  4. Animal pole localized Sox3 acts to inhibit Nodal (Xnr5 and Xnr6) expression, and induces the expression of genes (Ectodermin, Xema, and Coco) whose products repress Nodal signaling.

  5. Results demonstrate that both sox3 and sox2 are induced in response to BMP antagonism, but by distinct mechanisms and that the activation of both genes is independent of FGF signaling; however, both require FGF for the maintenance of their expression.

  6. Eya1 and Six1 are required for both the regulation of placodal neuronal progenitor proliferation, through their effects on SoxB1 expression, and subsequent neuronal differentiation.

SOX3 profil antigène

Antigen Summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency.

Gene names and symbols associated with SOX3

  • SRY-box 3 (SOX3) anticorps
  • transcription factor SOX-3 (Tsp_06143) anticorps
  • SRY-box 3 (sox3) anticorps
  • SRY (sex determining region Y)-box 3 (Sox3) anticorps
  • SRY (sex determining region Y)-box 3 (sox3) anticorps
  • SRY-box 3 S homeolog (sox3.S) anticorps
  • SRY-box 3 (Sox3) anticorps
  • CH3 anticorps
  • fc93f07 anticorps
  • GHDX anticorps
  • id:ibd2036 anticorps
  • mrgh anticorps
  • PHP anticorps
  • PHPX anticorps
  • sb:cb493 anticorps
  • Sox-3 anticorps
  • sox3-a anticorps
  • soxb anticorps
  • Sry anticorps
  • wu:fc93f07 anticorps
  • wu:fd02a08 anticorps
  • Xlsox3 anticorps
  • xSox-B1 anticorps
  • xSox3 anticorps
  • Xtsox3 anticorps
  • zgc:110279 anticorps

Protein level used designations for SOX3

transcription factor SOX-3 , SRY-related protein CH3 , cSox3 , transcription factor SOX3 , transcription factor Sox-3 , SRY (sex determining region Y)-box 3 , 2036 , transcription factor Sox-3-A , xSox3 , LOW QUALITY PROTEIN: transcription factor SOX-3 , SRY-box containing gene 3

6658 Homo sapiens
374019 Gallus gallus
10911545 Trichinella spiralis
493228 Xenopus (Silurana) tropicalis
100349101 Oryctolagus cuniculus
20675 Mus musculus
30529 Danio rerio
399335 Xenopus laevis
492178 Canis lupus familiaris
781679 Bos taurus
100623770 Sus scrofa
679158 Rattus norvegicus
Fournisseurs de qualité sélectionnés pour SOX3 (SOX3) Kits ELISA
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