ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 2 (ST8SIA2) Kits ELISA

Human ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 2 (ST8SIA2) interaction partners

1. 8 SNPs of ST8SIA2 and 2 SNPs of NCAM1 are associated with seasonality in mood changes and circadian preference

2. The ST8SIA2 risk haplotype copy number did not show any differential effects on white matter in schizophrenia.

3. Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4 have been described.

4. impairment of the regulated expression of ST8SIA2 and the resulting downstream effects on gene products by these two intronic single nucleotide polymorphism contribute to the development of these psychiatric disorders.

5. ST8SiaII role in the invasiveness and metastasis of small cell lung cancer cells

6. the relationships between psychiatric disorders and polySia and/or ST8SIA2

7. Data indicate a possible role of STX polysialyltransferase (ST8SIA2) in the common susceptibility of schizophrenia and bipolar I disorder (BD-I).

8. Our study showed interesting sex-specific associations between ST8SIAII and schizophrenia.

9. the role of ST8SIA2 sequence variation affecting polysialic acid-NCAM formation in 48 Caucasian cases with bipolar disorder

10. translational modification of the neural cell adhesion molecule NCAM and the polysialyltransferase ST8SiaII in mammalian semen involves polysialic acid

11. Expression of ST8SIA2 in omental fat at baseline was significantly associated with weight loss after Roux-en-Y gastric bypass.

12. that variation the ST8SIA2 gene is associated with increased risk to mental illness

13. NCAM and polySia are expressed and developmentally regulated in chick corneas. Both membrane-associated and soluble NCAM isoforms are expressed in chick corneas.

14. ST8SIA2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.

15. STX(G421A) shows a dramatic decrease in polySia synthetic activity on NCAM, whereas STX(C621G) does not; polySia shows a dopamine (DA) binding activity

16. This study provided that ST8SIA2 are associated with Bipolar I in the Han Chinese population.

17. SIAT8B has a role in neural development and sialic acid synthesis on NCAM

18. The upregulation of ST8SIA4 and the donwregulation of ST8SIA2 by valproic acid in HUVEC and tumor cell lines are reported.

19. SIAT8B gene is involved in schizophrenia in the Japanese.

20. Amino acid substitutions in conserved sequences are critical for the protein-specific polysialylation of NCAM.

Mouse (Murine) ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 2 (ST8SIA2) interaction partners

1. Results demonstrate that the early development of calbindin-positive periglomerular interneurons depends on the presentation of polysialic acid on NCAM and requires the activity of both St8sia2 and St8sia4

2. NCAM-140 significantly promoted cell proliferation, motility and migration, while polysialylation of NCAM-140 catalyzed by STX enhanced NCAM-mediated cell migration, but not cell proliferation or motility.

3. These results reveal that reduced polysialylation in St8sia2 (-/-) mice leads to pathological brain development and schizophrenia-like behavior.

4. This study demonstrated that St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.

5. Results indicate that the polySTs ST8SiaII and ST8SiaIV not only recognize an acidic patch in the FN1 domain of NCAM but also must contact sequences in the Ig5 domain for polysialylation of Ig5 N-glycans to occur.

6. Polysialylation of the synaptic cell adhesion molecule 1 (SynCAM 1) depends exclusively on the polysialyltransferase ST8SiaII in vivo.

7. results suggest that the ST8Sia5 gene increases ganglioside GQ1b and improves neuronal differentiation via the ERK1/2 MAP kinase pathway

8. While both ST8SiaII and ST8SiaIV mRNA levels decrease around the time of eye opening in mouse visual cortex, only ST8SiaII mRNA level reduction is regulated by sensory experience

9. At the mRNA level, the expression of GAD67 and of St8SiaII was significantly reduced by chronic stress in the amygdala of adult mice.

10. ST8sia2 knockout mice displayed both decreased social motivation and increased aggressive behavior not explained by olfactory deficits. They displayed reduced anxiety-like behavior, increased locomotion and stress-induced corticosterone secretion.

11. ST8SiaII is the major polysialyltransferase in immature neurons of the paleocortex layer II and the hippocampal subgranular zone.

12. Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior

13. the coordinated action of ST8SiaII and ST8SiaIV is crucial to fine-tune the amount and structure of polySia on NCAM

14. The developmental changes in neural cell adhesion molecule polysialylation in wild-type, ST8SiaII-, and ST8SiaIV-deficient mice from postnatal days 1 to 21 and from adult mice, was monitored.

15. Data show that ST8sia2 is expressed only in the neonatal atrium and action potential is altered consistently in ST8sia2((-/-)) atrial myocytes.