anti-STAM Binding Protein (STAMBP) Anticorps

Human STAM Binding Protein (STAMBP) interaction partners

1. these results indicate the importance of STAMBP in melanoma metastasis by regulating SLUG.

2. Contrary to previously reported STAMBP mutations, the Ser236Phe mutation did not lead to constitutive activation of the PI3K-AKT-mTOR pathway in patient-derived LCLs, as indicated by the expression of phosphorylated S6 ribosomal protein, suggesting that it is not the major pathomechanism underlying the disorder in this patient.

3. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity.

4. The authors propose a structural organization where the AMSH-SH3 binding motif interacts with the STAM2-SH3 domain and contributes to the correct positioning of AMSH prior to polyubiquitin chains' cleavage.

5. The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains

6. Two siblings with classic features of MIC-CAP syndrome that harbor a novel predicted splice mutation in STAMBP

7. associated molecule with the SH3 domain of STAM-mediated deubiquitination of connexin 43 protects Gap junctions from degradation

8. Recognition of the proximal ubiquitin is imperative for the linkage specificity and catalytic efficiency of AMSH.

9. Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome.

10. AMSH efficiently removes ubiquitin from the activated EGFR.

11. tight coupling of ESCRT-III CHMP3 and AMSH functions and provide insight into the regulation of ESCRT-III

12. Studies indicate that USP8/Ubpy and AMSH interact with ESCRT components to modulate the ubiquitination status of receptors and relevant sorting proteins.

13. AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4.

14. AMSH is a deubiquitinating enzyme with functions at the endosome to oppose ubiquitin-dependent receptor sorting

15. The cellular functions of UBPY are complex but clearly distinct from those of the Lys-63-ubiquitin-specific protease, AMSH, with which it shares a binding site on the SH3 domain of STAM

16. AMSH and AMSH-LP are anchored on the early endosomal membrane via interaction with the clathrin coat

17. AMSH has a role in the deubiquitination of the endosomal cargo preceding lysosomal degradation

18. AMSH, which has been recently characterized as a regulator of the endosomal sorting of epidermal growth factor receptor, represents a novel modulator of CaR signaling.

19. both the deubiquitination enzyme activity of AMSH and its CHMP3-binding ability are required to clear ubiquitinated cargo from endosomes

20. Endosomal AMSH (STAMBP) is a functional component of the multivesicular body pathway.

Mouse (Murine) STAM Binding Protein (STAMBP) interaction partners

1. These data suggest that AMSH plays an important role in degrading ubiquitinated proteins and glutamate receptors in vivo