anti-Sclerostin (SOST) Anticorps

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. De plus, nous expédions Sclerostin Kits (63) et Sclerostin Protéines (18) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67
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Top anti-Sclerostin Anticorps sur anticorps-enligne.fr

Showing 10 out of 129 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of anti-SOST Antibody (N-term) Pab (ABIN390193) in mouse liver tissue lysates (35 µg/lane). SOST (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with SOST antibody (N-term)(ABIN390193), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of SOST Antibody (Center) (ABIN390194) in mouse lung tissue lysates (35 µg/lane). SOST (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with SOST antibody (Center)(ABIN390194), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Lapin Inconjugué WB SOST Antibody (N-term)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the SOST antibody detected the SOST protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human kidney labeled with Rabbit Anti-Sclerostin Polyclonal Antibody, Unconjugated (ABIN1714867) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1: mouse lung probed with Rabbit Anti-Sclerostin Polyclonal Antibody, Unconjugated  at 1:5000 for 90 min at 37˚C. 100 μL Connectez-vous pour afficher 14 to 21 Days
$306.90
Détails
Humain Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Connectez-vous pour afficher 13 to 16 Days
$350.00
Détails
Souris Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Mouse Tissue 100 μg Connectez-vous pour afficher 13 to 16 Days
$360.00
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of lysates from human kidney and liver tissue lysates (from left to right), using SOST Antibody at 1:1000 at each lane. Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with SOST antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails

SOST Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-Sclerostin Anticorps mieux référencés

  1. Human Polyclonal Sclerostin Primary Antibody pour IHC (p), WB - ABIN390193 : Semenov, He: LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. dans The Journal of biological chemistry 2006 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal Sclerostin Primary Antibody pour EIA, IHC (p) - ABIN358751 : Ellies, Viviano, McCarthy, Rey, Itasaki, Saunders, Krumlauf: Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. dans Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 (PubMed)
    Show all 3 Pubmed References

Plus d’anticorps contre Sclerostin partenaires d’interaction

Human Sclerostin (SOST) interaction partners

  1. Sclerostin increased after exercise in comparison to baseline (mean +/- SEM: 410 +/- 27 vs. 290 +/- 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 +/-5.5%

  2. serum sclerostin levels correlated positively with carotid intima-media thickness and inversely with the augmentation index, a marker of arterial stiffness

  3. The difference of serum sclerostin levels in Ankylosing Spondylitis and Rheumatoid Arthritis patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of Ankylosing Spondylitis and Rheumatoid Arthritis.

  4. SOST gene silencing promotes the proliferation, invasion, and migration, and inhibits apoptosis of osteosarcoma cells by activating Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling pathway

  5. No difference was found in the serum sclerostin levels between the hyperthyroidism patients and healthy control.

  6. Positivity of RANKL (Montrer TNFSF11 Anticorps) and anti-CCP2 (Montrer AGBL2 Anticorps) yielded significant risk for progression with negativity for both as reference. No single nucleotide polymorphism encoding TNFSF11 (Montrer TNFSF11 Anticorps) or SOST was associated with increased concentrations of the factors.

  7. Osterix (Montrer SP7 Anticorps) and RUNX2 (Montrer RUNX2 Anticorps) are transcriptional regulators of sclerostin in human bone

  8. Sclerostin But Not Dickkopf-1 (Montrer DKK1 Anticorps) has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women

  9. An association was found between rs851054 of the SOST promoter and the fracture rate during childhood osteogenesis imperfecta (Montrer COL1A2 Anticorps).

  10. High serum levels of sclerostin and Dkk-1 (Montrer DKK1 Anticorps) are associated with acute ischaemic stroke

Mouse (Murine) Sclerostin (SOST) interaction partners

  1. our study provided histological evidences that sclerostin tends to be secreted in osteocytes of remodeled mature bone, while FGF23 (Montrer FGF23 Anticorps) would be differently synthesized in osteoblasts and osteocytes according to the developmental stages

  2. These results show that osteocytes and/or osteoblasts secrete factors regulating beige (Montrer LYST Anticorps) adipogenesis, at least in part, through the Wnt (Montrer WNT2 Anticorps)-signaling inhibitor sclerostin.

  3. In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (Montrer GJA1 Anticorps)+/-or Sost+/-mice

  4. loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (Montrer TNFSF11 Anticorps) and SOST, leading to osteoclast inhibition and Wnt (Montrer WNT2 Anticorps) activation together.

  5. humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (Montrer PFDN5 Anticorps).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.

  6. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin

  7. Osteocyte-derived molecule sclerostin drives bone marrow adipogenesis.

  8. complete absence of sclerostin has only minor effects on chronic kidney disease-induced bone loss in mice.

  9. In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.

  10. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

Sclerostin (SOST) profil antigène

Profil protéine

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Gene names and symbols associated with anti-Sclerostin (SOST) Anticorps

  • sclerostin (LOC100313724) anticorps
  • sclerostin (SOST) anticorps
  • sclerostin (Sost) anticorps
  • 5430411E23Rik anticorps
  • CDD anticorps
  • LOC100313724 anticorps
  • VBCH anticorps

Protein level used designations for anti-Sclerostin (SOST) Anticorps

sclerostin , sclerosteosis

GENE ID SPECIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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