Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. De plus, nous expédions Sclerostin Kits (63) et Sclerostin Protéines (18) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 129 products:
Human Polyclonal Sclerostin Primary Antibody pour IHC (p), WB - ABIN390193
Semenov, He: LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. dans The Journal of biological chemistry 2006
Show all 2 Pubmed References
Human Polyclonal Sclerostin Primary Antibody pour EIA, IHC (p) - ABIN358751
Ellies, Viviano, McCarthy, Rey, Itasaki, Saunders, Krumlauf: Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. dans Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006
Show all 3 Pubmed References
Sclerostin increased after exercise in comparison to baseline (mean +/- SEM: 410 +/- 27 vs. 290 +/- 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 +/-5.5%
serum sclerostin levels correlated positively with carotid intima-media thickness and inversely with the augmentation index, a marker of arterial stiffness
The difference of serum sclerostin levels in Ankylosing Spondylitis and Rheumatoid Arthritis patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of Ankylosing Spondylitis and Rheumatoid Arthritis.
SOST gene silencing promotes the proliferation, invasion, and migration, and inhibits apoptosis of osteosarcoma cells by activating Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling pathway
No difference was found in the serum sclerostin levels between the hyperthyroidism patients and healthy control.
Positivity of RANKL (Montrer TNFSF11 Anticorps) and anti-CCP2 (Montrer AGBL2 Anticorps) yielded significant risk for progression with negativity for both as reference. No single nucleotide polymorphism encoding TNFSF11 (Montrer TNFSF11 Anticorps) or SOST was associated with increased concentrations of the factors.
Osterix (Montrer SP7 Anticorps) and RUNX2 (Montrer RUNX2 Anticorps) are transcriptional regulators of sclerostin in human bone
Sclerostin But Not Dickkopf-1 (Montrer DKK1 Anticorps) has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women
An association was found between rs851054 of the SOST promoter and the fracture rate during childhood osteogenesis imperfecta (Montrer COL1A2 Anticorps).
High serum levels of sclerostin and Dkk-1 (Montrer DKK1 Anticorps) are associated with acute ischaemic stroke
our study provided histological evidences that sclerostin tends to be secreted in osteocytes of remodeled mature bone, while FGF23 (Montrer FGF23 Anticorps) would be differently synthesized in osteoblasts and osteocytes according to the developmental stages
These results show that osteocytes and/or osteoblasts secrete factors regulating beige (Montrer LYST Anticorps) adipogenesis, at least in part, through the Wnt (Montrer WNT2 Anticorps)-signaling inhibitor sclerostin.
In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (Montrer GJA1 Anticorps)+/-or Sost+/-mice
loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (Montrer TNFSF11 Anticorps) and SOST, leading to osteoclast inhibition and Wnt (Montrer WNT2 Anticorps) activation together.
humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (Montrer PFDN5 Anticorps).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.
Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin
Osteocyte-derived molecule sclerostin drives bone marrow adipogenesis.
complete absence of sclerostin has only minor effects on chronic kidney disease-induced bone loss in mice.
In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.
These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.